mitogen-activated protein kinase 3

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Synonym

PRKM3, Mitogen-activated protein kinase 3, MAPK 1, Extracellular signal-regulated kinase 1, ERK1, p44erk1, MGC20180, mitogen-activated protein kinase 3, MAPK3, MAP kinase 1, p44mapk, P44MAPK, ERT2, HS44KDAP, Microtubule-associated protein 2 kinase, p44-ERK1, P44ERK1, ERK-1, HUMKER1A, Insulin-stimulated MAP2 kinase, p44-MAPK

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:26.10 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:445 peripheral nerve:61.30 spine:- retina:- eye:70.50 artery/aorta:119.90 vein:- lymphnode:101.10 peripheral blood:36.40 spleen:37.80 thymus:25.80 bone marrow:- adipose:- bone:12.80 skin:52.80
GeneChip cerebrum:8.05 cerebellum:7.79 brain stem:7.97 corpus callosum/glia:7.87 pineal gland:- peripheral nerve:8.43 spine:7.98 retina:- eye:- artery/aorta:7.82 vein:7.67 lymphnode:7.69 peripheral blood:- spleen:7.43 thymus:7.26 bone marrow:7.56 adipose:7.96 bone:- skin:7.77
CAGE cerebrum:3.82 cerebellum:- brain stem:3.72 corpus callosum/glia:4.07 pineal gland:3.15 peripheral nerve:- spine:3.38 retina:- eye:- artery/aorta:3.70 vein:3.29 lymphnode:3.62 peripheral blood:- spleen:3.45 thymus:2.67 bone marrow:- adipose:3.81 bone:- skin:-
RNA-seq cerebrum:0.44 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.27 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.23 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:9.10 placenta:72.90 prostate:11.30 ovary:37.30 testis:17.30 heart:25.50 muscle:20.10 esophagus:342.80 stomach:- intestine:- colon:17     liver/hepato:42.20        lung:34.20    bladder:- kidney:41.60 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:35.60 breast:18.60 salivary:-
GeneChip uterus:7.59 placenta:7.51 prostate:7.38 ovary:7.68 testis:7.65 heart:7.56 muscle:7.39 esophagus:8.25 stomach:7.64 intestine:7.62 colon:8.11 liver/hepato:7.25 lung:7.71 bladder:- kidney:7.57 pituitary:7.74 thyroid/parathyroid:7.72 adrenal gland:7.54 pancreas:7.71 breast:7.67 salivary:7.46
CAGE uterus:3.84 placenta:3.90 prostate:3.70 ovary:3.87 testis:3.28 heart:3.41 muscle:2.68 esophagus:3.93 stomach:- intestine:4.58 colon:4.18     liver/hepato:2.77    lung:3.54 bladder:3.60 kidney:3.24 pituitary:2.81 thyroid/parathyroid:3.41 adrenal gland:- pancreas:2.60 breast:3.40 salivary:3.53
RNA-seq uterus:- placenta:- prostate:0.52 ovary:1.30 testis:0.75 heart:0.07 muscle:0.00 esophagus:- stomach:- intestine:- colon:1.35     liver/hepato:0.00        lung:0.25    bladder:- kidney:0.04 pituitary:- thyroid/parathyroid:0.24 adrenal gland:0.13 pancreas:- breast:0.69 salivary:-

IDs

Refseq ID NM_001109891
Gene ID 5595
Unigene ID Hs.86131
Probe set ID 212046_x_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000102882
GTEx ID ENSG00000102882

Orthologous Gene

Mouse[1]  NM_011952
Rat[1]  NM_011952

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed  (Pubmed ID)

862676
1319925
1322499
1347949
1463607
1540184
1922387
7535768
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Gene Ontology  (GO ID)

Biological Process

GO:0000187  activation of MAPK activity
GO:0000186  activation of MAPKK activity
GO:0006915  apoptosis
GO:0007411  axon guidance
GO:0007596  blood coagulation
GO:0030509  BMP signaling pathway
GO:0051216  cartilage development
GO:0007049  cell cycle
GO:0071260  cellular response to mechanical stimulus
GO:0019221  cytokine-mediated signaling pathway
GO:0007173  epidermal growth factor receptor signaling pathway
GO:0008543  fibroblast growth factor receptor signaling pathway
GO:0010467  gene expression
GO:0045087  innate immune response
GO:0008286  insulin receptor signaling pathway
GO:0070498  interleukin-1-mediated signaling pathway
GO:0060397  JAK-STAT cascade involved in growth hormone signaling pathway
GO:0031663  lipopolysaccharide-mediated signaling pathway
GO:0000165  MAPKKK cascade
GO:0002755  MyD88-dependent toll-like receptor signaling pathway
GO:0002756  MyD88-independent toll-like receptor signaling pathway
GO:0048011  nerve growth factor receptor signaling pathway
GO:0009887  organ morphogenesis
GO:0016310  phosphorylation
GO:0030168  platelet activation
GO:0070374  positive regulation of ERK1 and ERK2 cascade
GO:0035066  positive regulation of histone acetylation
GO:0033129  positive regulation of histone phosphorylation
GO:0001934  positive regulation of protein amino acid phosphorylation
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0006468  protein amino acid phosphorylation
GO:0007265  Ras protein signal transduction
GO:0051493  regulation of cytoskeleton organization
GO:0090170  regulation of Golgi inheritance
GO:0032872  regulation of stress-activated MAPK cascade
GO:0051090  regulation of transcription factor activity
GO:0006974  response to DNA damage stimulus
GO:0070849  response to epidermal growth factor stimulus
GO:0043330  response to exogenous dsRNA
GO:0019233  sensory perception of pain
GO:0007264  small GTPase mediated signal transduction
GO:0051403  stress-activated MAPK cascade
GO:0034166  toll-like receptor 10 signaling pathway
GO:0034134  toll-like receptor 2 signaling pathway
GO:0034138  toll-like receptor 3 signaling pathway
GO:0034142  toll-like receptor 4 signaling pathway
GO:0034146  toll-like receptor 5 signaling pathway
GO:0034162  toll-like receptor 9 signaling pathway
GO:0002224  toll-like receptor signaling pathway
GO:0006360  transcription from RNA polymerase I promoter
GO:0006361  transcription initiation from RNA polymerase I promoter
GO:0019048  virus-host interaction

Cellular Component

GO:0005901  caveola
GO:0005856  cytoskeleton
GO:0005829  cytosol
GO:0005769  early endosome
GO:0005925  focal adhesion
GO:0005794  Golgi apparatus
GO:0005770  late endosome
GO:0015630  microtubule cytoskeleton
GO:0005739  mitochondrion
GO:0005730  nucleolus
GO:0005654  nucleoplasm
GO:0005634  nucleus
GO:0031143  pseudopodium

Molecular Function

GO:0005524  ATP binding
GO:0004707  MAP kinase activity
GO:0019902  phosphatase binding
GO:0001784  phosphotyrosine binding
GO:0005515  protein binding