mitogen-activated protein kinase 6

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Synonym

HsT17250, Extracellular signal-regulated kinase 3, p97-MAPK, Mitogen-activated protein kinase 6, p97MAPK, PRKM6, mitogen-activated protein kinase 6, MAPK6, ERK-3, MAP kinase isoform p97, DKFZp686F03189

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:118.50 cerebellum:151.10 brain stem:- corpus callosum/glia:116.60 pineal gland:148.30 peripheral nerve:122.70 spine:- retina:118.60 eye:35.30 artery/aorta:119.90 vein:66.60 lymphnode:20.20 peripheral blood:36.40 spleen:18.90 thymus:51.50 bone marrow:78.70 adipose:- bone:12.80 skin:86.40
GeneChip cerebrum:8.55 cerebellum:9.68 brain stem:8.46 corpus callosum/glia:8.32 pineal gland:- peripheral nerve:7.38 spine:8.36 retina:- eye:- artery/aorta:7.34 vein:8.10 lymphnode:7.40 peripheral blood:- spleen:7.20 thymus:8.04 bone marrow:6.68 adipose:7.34 bone:- skin:8.56
CAGE cerebrum:3.80 cerebellum:- brain stem:3.77 corpus callosum/glia:3.45 pineal gland:3.44 peripheral nerve:- spine:3.50 retina:- eye:- artery/aorta:3.44 vein:2.85 lymphnode:3.19 peripheral blood:- spleen:3.12 thymus:3.13 bone marrow:- adipose:3.32 bone:- skin:-
RNA-seq cerebrum:4.52 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.76 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.24 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:109.40 placenta:18.20 prostate:45.10 ovary:37.30 testis:147.10 heart:12.80 muscle:20.10 esophagus:- stomach:297.40 intestine:32.40 colon:25.40     liver/hepato:63.30        lung:122.20    bladder:125.60 kidney:62.40 pituitary:- thyroid/parathyroid:163.70 adrenal gland:- pancreas:53.30 breast:213.70 salivary:-
GeneChip uterus:8.27 placenta:7.99 prostate:8.04 ovary:7.77 testis:8.61 heart:7.47 muscle:8.64 esophagus:8.71 stomach:7.68 intestine:7.92 colon:7.13 liver/hepato:8.25 lung:7.80 bladder:- kidney:7.22 pituitary:7.63 thyroid/parathyroid:7.72 adrenal gland:7.35 pancreas:7.05 breast:7.91 salivary:7.45
CAGE uterus:3.43 placenta:3.42 prostate:3.24 ovary:3.27 testis:3.96 heart:3.14 muscle:3.57 esophagus:3.79 stomach:- intestine:4.29 colon:3.46     liver/hepato:3.85    lung:3.52 bladder:3.75 kidney:3.31 pituitary:3.63 thyroid/parathyroid:2.74 adrenal gland:- pancreas:2.66 breast:3.43 salivary:2.99
RNA-seq uterus:- placenta:- prostate:3.41 ovary:3.56 testis:4.30 heart:2.49 muscle:3.70 esophagus:- stomach:- intestine:- colon:2.84     liver/hepato:3.82        lung:3.72    bladder:- kidney:3.51 pituitary:- thyroid/parathyroid:4.03 adrenal gland:2.87 pancreas:- breast:3.15 salivary:-

Gene Information

IDs

Refseq ID NM_002748
Gene ID 5597
Unigene ID Hs.411847
Probe set ID 207121_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000069956
GTEx ID ENSG00000069956

Orthologous Gene

Mouse[4]  NM_015806, NM_027418
Rat [0]  

Chromosomal Region

15q21.2  [52,311,417  -  52,358,462]

Gene Family (Interpro ID)

IPR008350  ERK3/4 MAP kinase
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

2032290
7969157
8621539
8626698
8875998
11148204
11741894
12239168
12477932
12808096
12915405
15172640
15226418
15489334
16344560
16360641
16964379
18235225
18720373
19322201
20936779
21139048
21317288
21890473
21900206
21906983
21988832
22190034
22261722
22505454
22645313
23602568

Gene Ontology  (GO ID)

Biological Process

GO:0007049  cell cycle
GO:0006468  protein amino acid phosphorylation
GO:0007165  signal transduction

Cellular Component

GO:0005737  cytoplasm
GO:0005634  nucleus

Molecular Function

GO:0005524  ATP binding
GO:0004707  MAP kinase activity
GO:0005515  protein binding
GO:0046982  protein heterodimerization activity
GO:0019901  protein kinase binding
GO:0004674  protein serine/threonine kinase activity