mitogen-activated protein kinase 9

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Synonym

JNK2B, c-Jun N-terminal kinase 2, JNK2, JNK-55, mitogen-activated protein kinase 9, JNK2BETA, MAPK9, p54aSAPK, Mitogen-activated protein kinase 9, Stress-activated protein kinase JNK2, JNK2ALPHA, PRKM9, JNK2A, Jun kinase

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:75.80 cerebellum:63 brain stem:- corpus callosum/glia:29.20 pineal gland:- peripheral nerve:61.30 spine:- retina:- eye:88.20 artery/aorta:- vein:199.90 lymphnode:30.30 peripheral blood:36.40 spleen:- thymus:12.90 bone marrow:19.70 adipose:- bone:25.60 skin:57.60
GeneChip cerebrum:7.21 cerebellum:8.21 brain stem:7.70 corpus callosum/glia:6.42 pineal gland:- peripheral nerve:7.28 spine:7.19 retina:- eye:- artery/aorta:6.19 vein:6.15 lymphnode:6.84 peripheral blood:- spleen:6.77 thymus:6.98 bone marrow:6.51 adipose:6.64 bone:- skin:6.08
CAGE cerebrum:3.89 cerebellum:- brain stem:3.79 corpus callosum/glia:3.26 pineal gland:2.42 peripheral nerve:- spine:3.30 retina:- eye:- artery/aorta:2.96 vein:2.57 lymphnode:2.63 peripheral blood:- spleen:2.89 thymus:2.75 bone marrow:- adipose:2.70 bone:- skin:-
RNA-seq cerebrum:1.49 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.30 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:1.37 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:36.50 placenta:69.20 prostate:33.80 ovary:37.30 testis:51.90 heart:12.80 muscle:120.50 esophagus:- stomach:21.20 intestine:32.40 colon:67.80     liver/hepato:73.90        lung:92.90    bladder:- kidney:93.60 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:17.80 breast:55.80 salivary:-
GeneChip uterus:6.39 placenta:7.60 prostate:6.86 ovary:6.16 testis:6.37 heart:6.06 muscle:5.96 esophagus:6.44 stomach:6.62 intestine:6.82 colon:6.42 liver/hepato:5.47 lung:6.74 bladder:- kidney:6.52 pituitary:6.35 thyroid/parathyroid:6.85 adrenal gland:6.96 pancreas:7.04 breast:6.54 salivary:6.90
CAGE uterus:2.74 placenta:3.06 prostate:3.00 ovary:2.81 testis:2.88 heart:3.02 muscle:2.85 esophagus:2.75 stomach:- intestine:2.92 colon:2.92     liver/hepato:2.63    lung:3.02 bladder:2.98 kidney:2.74 pituitary:2.63 thyroid/parathyroid:2.99 adrenal gland:- pancreas:3.57 breast:3.45 salivary:3.08
RNA-seq uterus:- placenta:- prostate:2.07 ovary:1.24 testis:1.38 heart:1.90 muscle:0.00 esophagus:- stomach:- intestine:- colon:0.88     liver/hepato:0.00        lung:0.00    bladder:- kidney:0.52 pituitary:- thyroid/parathyroid:1.09 adrenal gland:1.30 pancreas:- breast:1.22 salivary:-

Gene Information

IDs

Refseq ID NM_139068
Gene ID 5601
Unigene ID Hs.484371
Probe set ID 203218_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000050748
GTEx ID ENSG00000050748

Orthologous Gene

Mouse[12]  NM_001163671, NM_001163672, NM_016961, NM_207692
Rat [0]  

Chromosomal Region

5q35.3  [179,660,143  -  179,719,099]

Gene Family (Interpro ID)

IPR008351  JNK MAP kinase
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

602896
1602151
7642542
7737129
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Gene Ontology  (GO ID)

Biological Process

GO:0071363  cellular response to growth factor stimulus
GO:0071347  cellular response to interleukin-1
GO:0071222  cellular response to lipopolysaccharide
GO:0071356  cellular response to tumor necrosis factor
GO:0034644  cellular response to UV
GO:0007417  central nervous system development
GO:0045087  innate immune response
GO:0007254  JNK cascade
GO:0002755  MyD88-dependent toll-like receptor signaling pathway
GO:0002756  MyD88-independent toll-like receptor signaling pathway
GO:0031175  neuron projection development
GO:0043065  positive regulation of apoptosis
GO:0010770  positive regulation of cell morphogenesis involved in differentiation
GO:0032722  positive regulation of chemokine production
GO:0010628  positive regulation of gene expression
GO:0010744  positive regulation of macrophage derived foam cell differentiation
GO:0045429  positive regulation of nitric oxide biosynthetic process
GO:0051770  positive regulation of nitric-oxide synthase biosynthetic process
GO:0031394  positive regulation of prostaglandin biosynthetic process
GO:0032308  positive regulation of prostaglandin secretion
GO:0001934  positive regulation of protein amino acid phosphorylation
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0006626  protein targeting to mitochondrion
GO:0046328  regulation of JNK cascade
GO:0031396  regulation of protein ubiquitination
GO:0051090  regulation of transcription factor activity
GO:0001836  release of cytochrome c from mitochondria
GO:0014075  response to amine stimulus
GO:0046686  response to cadmium ion
GO:0042493  response to drug
GO:0009612  response to mechanical stimulus
GO:0006950  response to stress
GO:0009636  response to toxin
GO:0051403  stress-activated MAPK cascade
GO:0034166  toll-like receptor 10 signaling pathway
GO:0034134  toll-like receptor 2 signaling pathway
GO:0034138  toll-like receptor 3 signaling pathway
GO:0034142  toll-like receptor 4 signaling pathway
GO:0034146  toll-like receptor 5 signaling pathway
GO:0034162  toll-like receptor 9 signaling pathway
GO:0002224  toll-like receptor signaling pathway

Cellular Component

GO:0005829  cytosol
GO:0005739  mitochondrion
GO:0005654  nucleoplasm

Molecular Function

GO:0005524  ATP binding
GO:0008656  caspase activator activity
GO:0004705  JUN kinase activity
GO:0031435  mitogen-activated protein kinase kinase kinase binding
GO:0005515  protein binding
GO:0008134  transcription factor binding