mitogen-activated protein kinase 10

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Synonym

JNK3A, p54bSAPK, PRKM10, c-Jun N-terminal kinase 3, MAPK10, FLJ12099, mitogen-activated protein kinase 10, Stress-activated protein kinase JNK3, JNK3, Mitogen-activated protein kinase 10, MAP kinase p49 3F12, p493F12, FLJ33785, MGC50974

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:393.50 cerebellum:302.30 brain stem:- corpus callosum/glia:87.50 pineal gland:148.30 peripheral nerve:61.30 spine:- retina:- eye:111.70 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:94.50 thymus:12.90 bone marrow:- adipose:161.30 bone:38.40 skin:9.60
GeneChip cerebrum:8.34 cerebellum:7.54 brain stem:8.49 corpus callosum/glia:7.47 pineal gland:- peripheral nerve:7.82 spine:8.16 retina:- eye:- artery/aorta:6.81 vein:6.57 lymphnode:6.49 peripheral blood:- spleen:6.39 thymus:6.38 bone marrow:6.65 adipose:7.16 bone:- skin:6.27
CAGE cerebrum:5.42 cerebellum:- brain stem:5.12 corpus callosum/glia:4.56 pineal gland:3.79 peripheral nerve:- spine:5.37 retina:- eye:- artery/aorta:2.90 vein:3.05 lymphnode:1.66 peripheral blood:- spleen:1.76 thymus:1.26 bone marrow:- adipose:3.04 bone:- skin:-
RNA-seq cerebrum:4.21 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.34 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:1.81 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:191.40 placenta:3.60 prostate:123.90 ovary:37.30 testis:134.10 heart:25.50 muscle:- esophagus:- stomach:21.20 intestine:97.20 colon:-     liver/hepato:-        lung:44    bladder:125.60 kidney:83.20 pituitary:232 thyroid/parathyroid:163.70 adrenal gland:50.80 pancreas:186.70 breast:18.60 salivary:-
GeneChip uterus:7.35 placenta:6.25 prostate:7.51 ovary:6.99 testis:6.64 heart:6.35 muscle:6.32 esophagus:6.31 stomach:6.62 intestine:6.51 colon:6.66 liver/hepato:6.46 lung:6.28 bladder:- kidney:6.96 pituitary:7.82 thyroid/parathyroid:6.96 adrenal gland:7.02 pancreas:6.57 breast:6.34 salivary:6.53
CAGE uterus:4.12 placenta:1.17 prostate:3.85 ovary:3.31 testis:3.38 heart:2.46 muscle:0.66 esophagus:2.36 stomach:- intestine:2.06 colon:2.79     liver/hepato:0.63    lung:2.91 bladder:3.29 kidney:3.26 pituitary:5.20 thyroid/parathyroid:3.15 adrenal gland:- pancreas:2.08 breast:3.30 salivary:1.49
RNA-seq uterus:- placenta:- prostate:3.59 ovary:2.49 testis:2.66 heart:0.29 muscle:0.00 esophagus:- stomach:- intestine:- colon:1.94     liver/hepato:0.08        lung:1.64    bladder:- kidney:2.18 pituitary:- thyroid/parathyroid:1.57 adrenal gland:1.28 pancreas:- breast:3.49 salivary:-

Gene Information

IDs

Refseq ID NM_002753
Gene ID 5602
Unigene ID Hs.125503
Probe set ID 204813_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000109339
GTEx ID ENSG00000109339

Orthologous Gene

Mouse[8]  NM_001081567, NM_009158
Rat [0]  

Chromosomal Region

4q21.3  [86,936,276  -  87,515,284]

Gene Family (Interpro ID)

IPR008351  JNK MAP kinase
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

1922387
7826642
8125298
8619474
8654373
9045910
9110174
9349820
9393873
9403476
9739089
9847074
10383391
10471813
10523642
10629060
10715136
10756100
10878576
11090355
11185509
11231586
11259409
11322657
11356842
11359773
11468147
11504923
11698270
11718727
11823425
12089333
12167088
12189133
12239168
12436199
12477932
12714584
12775419
12788955
12818176
12857973
12960231
12963725
14702039
15246824
15276183
15299005
15489334
15603708
15693750
16007099
16169070
16249883
16344560
16481105
16611996
16737965
16824735
17670986
17680991
18408005
18624398
19001375
19204086
19294699
19527717
19782076
19879840
20056178
20525557
20936779
21041242
21166945
21321401
21832049
21988832
22001757
22047447
22505724
22523077
23142346
23329067
23602568

Gene Ontology  (GO ID)

Biological Process

GO:0000187  activation of MAPK activity
GO:0045087  innate immune response
GO:0007254  JNK cascade
GO:0007258  JUN phosphorylation
GO:0002755  MyD88-dependent toll-like receptor signaling pathway
GO:0002756  MyD88-independent toll-like receptor signaling pathway
GO:0051090  regulation of transcription factor activity
GO:0007165  signal transduction
GO:0051403  stress-activated MAPK cascade
GO:0034166  toll-like receptor 10 signaling pathway
GO:0034134  toll-like receptor 2 signaling pathway
GO:0034138  toll-like receptor 3 signaling pathway
GO:0034142  toll-like receptor 4 signaling pathway
GO:0034146  toll-like receptor 5 signaling pathway
GO:0034162  toll-like receptor 9 signaling pathway
GO:0002224  toll-like receptor signaling pathway

Cellular Component

GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0005739  mitochondrion
GO:0005654  nucleoplasm
GO:0005886  plasma membrane

Molecular Function

GO:0005524  ATP binding
GO:0004705  JUN kinase activity
GO:0004708  MAP kinase kinase activity
GO:0005515  protein binding