mitogen-activated protein kinase kinase 1

Synonym

MAP kinase kinase 1, mitogen-activated protein kinase kinase 1, MAPK/ERK kinase 1, ERK activator kinase 1, MAPKK1, MEK1, PRKMK1, MAPKK 1, MKK1, MAP2K1

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:39.10

cerebellum:12.60

brain stem:-

corpus callosum/glia:58.30

pineal gland:148.30

peripheral nerve:61.30

spine:112.30

retina:-

eye:35.30

artery/aorta:89.90

vein:66.60

lymphnode:151.70

peripheral blood:72.90

spleen:37.80

thymus:51.50

bone marrow:137.80

adipose:-

bone:38.40

skin:72

GeneChip

cerebrum:8.93

cerebellum:8.94

brain stem:8.25

corpus callosum/glia:7.72

pineal gland:-

peripheral nerve:8.58

spine:8.40

retina:-

eye:-

artery/aorta:7.59

vein:8.20

lymphnode:8.19

peripheral blood:-

spleen:8.02

thymus:7.96

bone marrow:8.23

adipose:8.49

bone:-

skin:7.66

CAGE

cerebrum:4.64

cerebellum:-

brain stem:3.69

corpus callosum/glia:3.45

pineal gland:3.85

peripheral nerve:-

spine:4.27

retina:-

eye:-

artery/aorta:4.24

vein:3.76

lymphnode:3.91

peripheral blood:-

spleen:3.87

thymus:3.64

bone marrow:-

adipose:4.18

bone:-

skin:-

RNA-seq

cerebrum:5.53

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:4.79

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:4.16

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:109.40

placenta:10.90

prostate:67.60

ovary:-

testis:26

heart:76.60

muscle:-

esophagus:-

stomach:42.50

intestine:32.40

colon:76.30

liver/hepato:52.80

lung:73.30

bladder:-

kidney:31.20

pituitary:116

thyroid/parathyroid:-

adrenal gland:101.60

pancreas:44.50

breast:55.80

salivary:-

GeneChip

uterus:7.72

placenta:7.18

prostate:8.13

ovary:7.72

testis:7.19

heart:7.96

muscle:9

esophagus:8.73

stomach:7.73

intestine:7.96

colon:7.77

liver/hepato:8.53

lung:8.23

bladder:-

kidney:8.02

pituitary:7.83

thyroid/parathyroid:7.67

adrenal gland:7.73

pancreas:7.46

breast:7.81

salivary:7.78

CAGE

uterus:3.44

placenta:3.28

prostate:3.55

ovary:3.59

testis:2.96

heart:4.14

muscle:4.54

esophagus:3.77

stomach:-

intestine:3.48

colon:3.65

liver/hepato:4.12

lung:4.10

bladder:3.88

kidney:3.72

pituitary:3.82

thyroid/parathyroid:3.44

adrenal gland:-

pancreas:3.67

breast:4.46

salivary:3.27

RNA-seq

uterus:-

placenta:-

prostate:4.31

ovary:4.02

testis:4.00

heart:3.89

muscle:4.11

esophagus:-

stomach:-

intestine:-

colon:4.07

liver/hepato:4.03

lung:4.83

bladder:-

kidney:4.41

pituitary:-

thyroid/parathyroid:4.05

adrenal gland:4.03

pancreas:-

breast:5.05

salivary:-

IDs

Refseq ID	NM_002755
Gene ID	5604
Unigene ID	Hs.145442
Probe set ID	202670_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000169032
GTEx ID	ENSG00000169032

Orthologous Gene

Mouse[1]	NM_008927
Rat [0]

Chromosomal Region

15q22.31 [66,679,155 - 66,783,882]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR000719	Protein kinase, catalytic domain
IPR011009	Protein kinase-like domain
IPR002290	Serine/threonine-protein kinase domain
IPR017442	Serine/threonine-protein kinase-like domain
IPR001245	Tyrosine-protein kinase, catalytic domain
IPR020635	Tyrosine-protein kinase, subgroup, catalytic domain

Gene Ontology (GO ID)

Biological Process

GO:0000187	activation of MAPK activity
GO:0000186	activation of MAPKK activity
GO:0007411	axon guidance
GO:0007050	cell cycle arrest
GO:0048870	cell motility
GO:0008283	cell proliferation
GO:0006928	cellular component movement
GO:0006935	chemotaxis
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0048313	Golgi inheritance
GO:0045087	innate immune response
GO:0008286	insulin receptor signaling pathway
GO:0030216	keratinocyte differentiation
GO:0060711	labyrinthine layer development
GO:0000165	MAPKKK cascade
GO:0032402	melanosome transport
GO:0007067	mitosis
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0002756	MyD88-independent toll-like receptor signaling pathway
GO:0008285	negative regulation of cell proliferation
GO:0034111	negative regulation of homotypic cell-cell adhesion
GO:0048011	nerve growth factor receptor signaling pathway
GO:0060674	placenta blood vessel development
GO:0045597	positive regulation of cell differentiation
GO:0030335	positive regulation of cell migration
GO:0032320	positive regulation of Ras GTPase activity
GO:0046579	positive regulation of Ras protein signal transduction
GO:0032968	positive regulation of RNA elongation from RNA polymerase II promoter
GO:0051291	protein heterooligomerization
GO:0007265	Ras protein signal transduction
GO:0090170	regulation of Golgi inheritance
GO:0032872	regulation of stress-activated MAPK cascade
GO:0003056	regulation of vascular smooth muscle contraction
GO:0048678	response to axon injury
GO:0051384	response to glucocorticoid stimulus
GO:0006979	response to oxidative stress
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0051403	stress-activated MAPK cascade
GO:0034166	toll-like receptor 10 signaling pathway
GO:0034134	toll-like receptor 2 signaling pathway
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0034146	toll-like receptor 5 signaling pathway
GO:0034162	toll-like receptor 9 signaling pathway
GO:0002224	toll-like receptor signaling pathway
GO:0047496	vesicle transport along microtubule

Cellular Component

GO:0005938	cell cortex
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0032839	dendrite cytoplasm
GO:0005769	early endosome
GO:0005925	focal adhesion
GO:0005794	Golgi apparatus
GO:0005770	late endosome
GO:0005739	mitochondrion
GO:0005634	nucleus
GO:0043204	perikaryon
GO:0048471	perinuclear region of cytoplasm
GO:0005886	plasma membrane
GO:0005816	spindle pole body

Molecular Function

GO:0005524	ATP binding
GO:0004708	MAP kinase kinase activity
GO:0031435	mitogen-activated protein kinase kinase kinase binding
GO:0005515	protein binding
GO:0004672	protein kinase activity
GO:0043539	protein serine/threonine kinase activator activity
GO:0004674	protein serine/threonine kinase activity
GO:0004712	protein serine/threonine/tyrosine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0017016	Ras GTPase binding
GO:0004728	receptor signaling protein tyrosine phosphatase activity

mitogen-activated protein kinase kinase 1

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function