mitogen-activated protein kinase kinase 6

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Synonym

mitogen-activated protein kinase kinase 6, MAPK/ERK kinase 6, PRKMK6, MAPKK 6, MEK6, MAP kinase kinase 6, MAP2K6, SAPKK3, MAPKK6, MKK6

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:21.30 cerebellum:12.60 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:118.60 eye:29.40 artery/aorta:- vein:- lymphnode:30.30 peripheral blood:- spleen:- thymus:12.90 bone marrow:- adipose:- bone:38.40 skin:14.40
GeneChip cerebrum:5.79 cerebellum:6.01 brain stem:5.93 corpus callosum/glia:5.93 pineal gland:- peripheral nerve:5.89 spine:6.06 retina:- eye:- artery/aorta:5.41 vein:5.76 lymphnode:5.87 peripheral blood:- spleen:5.65 thymus:6.58 bone marrow:6.54 adipose:5.83 bone:- skin:5.54
CAGE cerebrum:2.83 cerebellum:- brain stem:2.93 corpus callosum/glia:3.03 pineal gland:2.14 peripheral nerve:- spine:3.08 retina:- eye:- artery/aorta:1.85 vein:3.00 lymphnode:3.12 peripheral blood:- spleen:2.50 thymus:3.55 bone marrow:- adipose:2.48 bone:- skin:-
RNA-seq cerebrum:1.65 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.32 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:1.13 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:27.30 placenta:14.60 prostate:- ovary:- testis:8.70 heart:51.10 muscle:80.40 esophagus:- stomach:21.20 intestine:- colon:42.40     liver/hepato:21.10        lung:4.90    bladder:- kidney:10.40 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:26.70 breast:9.30 salivary:-
GeneChip uterus:6.10 placenta:5.28 prostate:5.54 ovary:5.63 testis:5.10 heart:6.04 muscle:8.03 esophagus:5.73 stomach:6.22 intestine:6.53 colon:7.27 liver/hepato:6.51 lung:5.65 bladder:- kidney:5.97 pituitary:5.62 thyroid/parathyroid:5.19 adrenal gland:5.38 pancreas:6.13 breast:5.79 salivary:5.60
CAGE uterus:2.79 placenta:1.08 prostate:2.07 ovary:1.83 testis:1.49 heart:1.90 muscle:4.29 esophagus:2.10 stomach:- intestine:2.82 colon:3.43     liver/hepato:1.33    lung:2.03 bladder:1.52 kidney:2.54 pituitary:2.36 thyroid/parathyroid:1.74 adrenal gland:- pancreas:2.34 breast:1.36 salivary:2.57
RNA-seq uterus:- placenta:- prostate:1.20 ovary:1.08 testis:0.87 heart:0.80 muscle:3.91 esophagus:- stomach:- intestine:- colon:1.15     liver/hepato:0.67        lung:0.71    bladder:- kidney:1.48 pituitary:- thyroid/parathyroid:2.01 adrenal gland:1.92 pancreas:- breast:1.85 salivary:-

Gene Information

IDs

Refseq ID NM_002758
Gene ID 5608
Unigene ID Hs.463978
Probe set ID 205698_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000108984
GTEx ID ENSG00000108984

Orthologous Gene

Mouse[1]  NM_011943
Rat [0]  

Chromosomal Region

17q24.3  [67,410,838  -  67,538,451]

Gene Family (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

7750576
8125298
8621675
8622669
8626699
8663074
8861944
9218798
9430721
9768359
9808624
9841871
10094049
10497253
10570156
10702308
10838074
10848581
10961885
11062067
11062068
11104681
11279118
11460167
11562357
11689443
11727828
11836244
11971971
12054652
12242293
12477932
12509443
12556533
12589052
12609980
12697810
12761180
12820963
14633987
15229216
15276183
15375157
15489334
15492008
15516490
15550393
15590691
15677464
15717329
15722372
15764709
15778394
15790570
15866172
15923648
16157600
16313339
16342939
16344560
16498455
16728640
16893890
16960152
17079228
17255097
17255949
17363905
17363973
17384642
18327563
19047046
19141286
19234473
19302196
19672773
19675569
19737936
19846005
19913121
20067578
20162623
20213747
20364819
20628086
20706999
20805296
20869211
20932476
21078955
21139048
21308746
21368234
21890473
21926646
22154358
22164285
22383536
22569225
23535064
23606331
23744074
24936062

Gene Ontology  (GO ID)

Biological Process

GO:0000187  activation of MAPK activity
GO:0006915  apoptosis
GO:0060048  cardiac muscle contraction
GO:0007050  cell cycle arrest
GO:0006975  DNA damage induced protein phosphorylation
GO:0045087  innate immune response
GO:0042692  muscle cell differentiation
GO:0002755  MyD88-dependent toll-like receptor signaling pathway
GO:0002756  MyD88-independent toll-like receptor signaling pathway
GO:0070423  nucleotide-binding oligomerization domain containing signaling pathway
GO:0043065  positive regulation of apoptosis
GO:0051149  positive regulation of muscle cell differentiation
GO:0006355  regulation of transcription, DNA-dependent
GO:0042493  response to drug
GO:0007165  signal transduction
GO:0051403  stress-activated MAPK cascade
GO:0034166  toll-like receptor 10 signaling pathway
GO:0034134  toll-like receptor 2 signaling pathway
GO:0034138  toll-like receptor 3 signaling pathway
GO:0034142  toll-like receptor 4 signaling pathway
GO:0034146  toll-like receptor 5 signaling pathway
GO:0034162  toll-like receptor 9 signaling pathway
GO:0002224  toll-like receptor signaling pathway
GO:0006351  transcription, DNA-dependent

Cellular Component

GO:0005856  cytoskeleton
GO:0005829  cytosol
GO:0005654  nucleoplasm

Molecular Function

GO:0005524  ATP binding
GO:0004708  MAP kinase kinase activity
GO:0005515  protein binding
GO:0019901  protein kinase binding
GO:0004674  protein serine/threonine kinase activity
GO:0004713  protein tyrosine kinase activity