eukaryotic translation initiation factor 2-alpha kinase 2

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Synonym

Protein kinase RNA-activated, Interferon-inducible RNA-dependent protein kinase, p68 kinase, PRKR, PKR, EIF2AK2, MGC126524, EIF2AK1, P1/eIF-2A protein kinase

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:6.16 cerebellum:5.94 brain stem:6.15 corpus callosum/glia:6.12 pineal gland:- peripheral nerve:6.46 spine:6.31 retina:- eye:- artery/aorta:5.91 vein:5.99 lymphnode:6.19 peripheral blood:- spleen:6.46 thymus:6.36 bone marrow:6.27 adipose:6.04 bone:- skin:5.64
CAGE cerebrum:3.15 cerebellum:- brain stem:3.19 corpus callosum/glia:2.95 pineal gland:2.65 peripheral nerve:- spine:3.29 retina:- eye:- artery/aorta:3.17 vein:3.14 lymphnode:2.86 peripheral blood:- spleen:3.21 thymus:3.06 bone marrow:- adipose:3.81 bone:- skin:-
RNA-seq cerebrum:2.52 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.92 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.19 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:6.41 placenta:5.99 prostate:6.29 ovary:6.32 testis:5.45 heart:5.96 muscle:5.59 esophagus:5.91 stomach:6.03 intestine:6.10 colon:5.84 liver/hepato:5.94 lung:6.05 bladder:- kidney:5.79 pituitary:6.25 thyroid/parathyroid:6.02 adrenal gland:5.98 pancreas:5.96 breast:6.02 salivary:5.94
CAGE uterus:3.42 placenta:3.38 prostate:3.38 ovary:3.51 testis:2.47 heart:3.07 muscle:2.11 esophagus:3.07 stomach:- intestine:3.08 colon:2.87     liver/hepato:2.90    lung:3.30 bladder:3.32 kidney:3.01 pituitary:3.30 thyroid/parathyroid:3.13 adrenal gland:- pancreas:2.48 breast:3.12 salivary:2.60
RNA-seq uterus:- placenta:- prostate:2.11 ovary:3.56 testis:2.62 heart:2.05 muscle:1.26 esophagus:- stomach:- intestine:- colon:2.57     liver/hepato:1.38        lung:2.20    bladder:- kidney:1.22 pituitary:- thyroid/parathyroid:2.84 adrenal gland:2.51 pancreas:- breast:2.85 salivary:-

IDs

Refseq ID NM_001135651
Gene ID 5610
Unigene ID -
Probe set ID 204211_x_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000055332
GTEx ID ENSG00000055332

Orthologous Gene

Mouse[2]  NM_011163
Rat[2]  NM_011163

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed  (Pubmed ID)

1351683
1373553
1373554
1677563
1695551
1708818
2180064
7491766
7568151
7686883
7686884
7738010
7757816
8099444
8576172
8601309
8812437
8887659
8889548
8921913
9079663
9135145
9143277
9214631
9447982
9528799
9687506
9721103
9726442
9735304
9736623
9781815
9819435
10320367
10330179
10348343
10390359
10400669
10400814
10542257
10557102
10620360
10648614
10684936
10723127
10747897
10848580
10866685
10884347
11123929
11152499
11238927
11278865
11337501
11350938
11438532
11438536
11438540
11447118
11468270
11526399
11555640
11773402
11836380
11921349
11985496
11991642
12051728
12055262
12060652
12138106
12231563
12349906
12368306
12368348
12396729
12397061
12447867
12473108
12477932
12483527
12539042
12609980
12665801
12679338
12882984
12944978
13678666
14638359
14698665
14765129
14961569
15121867
15122791
15207627
15229216
15299030
15489334
15535414
15596837
15607693
15625311
15635413
15737233
15815621
15880455
15907845
16009940
16156900
16216244
16271080
16288713
16339759
16373505
16446363
16466763
16580685
16785445
16861340
16861808
16924232
16954686
16957780
16989899
17202131
17284445
17290288
17307214
17318221
17353931
17420072
17451862
17522227
17541283
17596833
17597457
17612505
17686861
17716668
17785458
17851256
17928244
17928446
17959656
17975119
17977969
18023289
18048689
18063576
18087277
18362360
18426922
18496558
18599499
18684815
18684960
18728014
18835251
18927075
18936160
18957415
18976633
18991615
19004947
19023099
19028691
19106640
19109397
19151623
19189853
19210572
19229320
19259124
19322201
19349624
19353519
19364808
19416861
19434718
19445956
19507191
19515768
19605474
19605483
19642004
19651874
19710021
19733181
19744687
19776135
19812373
19840259
19846517
19846675
19946888
20006836
20006840
20171114
20181660
20309637
20331378
20353946
20395957
20447405
20485506
20587610
20588308
20628624
20685959
20930042
21029237
21048031
21072047
21123378
21123651
21139048
21145461
21294215
21338484
21377708
21385567
21464971
21468538
21504114
21526770
21698289
21710204
21715487
21790829
21846836
21882225
21890473
21903422
21906983
21907836
22022264
22102852
22174754
22190034
22278235
22281122
22306812
22381929
22473766
22647704
22787234
22801494
22894766
22896602
22912486
22939624
22939629
22948139
22986343
23064357
23084476
23115276
23115300
23148689
23151878
23221979
23229543
23302873
23314571
23320095
23370317
23372823
23376165
23399035
23455922
23527187
23682076
23706307
23853588
24020926
24089560
24163370
24334130
24463368
24623135
24778252
24797263
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0000186  activation of MAPKK activity
GO:0051607  defense response to virus
GO:0030968  endoplasmic reticulum unfolded protein response
GO:0030683  evasion by virus of host immune response
GO:0045087  innate immune response
GO:0019054  modulation by virus of host cellular process
GO:0008285  negative regulation of cell proliferation
GO:0033689  negative regulation of osteoblast proliferation
GO:0017148  negative regulation of translation
GO:0045071  negative regulation of viral genome replication
GO:0032722  positive regulation of chemokine production
GO:0001819  positive regulation of cytokine production
GO:0051092  positive regulation of NF-kappaB transcription factor activity
GO:0032874  positive regulation of stress-activated MAPK cascade
GO:0046777  protein amino acid autophosphorylation
GO:0006468  protein amino acid phosphorylation
GO:0009615  response to virus
GO:0006351  transcription, DNA-dependent
GO:0006412  translation
GO:0019058  viral infectious cycle
GO:0019048  virus-host interaction
GO:0006926  virus-infected cell apoptosis

Cellular Component

GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0005634  nucleus
GO:0048471  perinuclear region of cytoplasm

Molecular Function

GO:0005524  ATP binding
GO:0003725  double-stranded RNA binding
GO:0004694  eukaryotic translation initiation factor 2alpha kinase activity
GO:0004715  non-membrane spanning protein tyrosine kinase activity
GO:0005515  protein binding
GO:0004672  protein kinase activity
GO:0008601  protein phosphatase type 2A regulator activity
GO:0004674  protein serine/threonine kinase activity