presenilin 2 (Alzheimer disease 4)

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Synonym

AD5, AD3L, STM2, presenilin 2 (Alzheimer disease 4), STM-2, AD3LP, E5-1, PSEN2, Presenilin-2, PSNL2, PS-2, AD4

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:36.70

cerebellum:37.80

brain stem:-

corpus callosum/glia:58.30

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:76.40

artery/aorta:30

vein:-

lymphnode:30.30

peripheral blood:72.90

spleen:170.20

thymus:12.90

bone marrow:-

adipose:80.70

bone:51.20

skin:43.20

GeneChip

cerebrum:6.09

cerebellum:6.65

brain stem:6.33

corpus callosum/glia:5.62

pineal gland:-

peripheral nerve:6.19

spine:5.98

retina:-

eye:-

artery/aorta:6

vein:6.25

lymphnode:6.48

peripheral blood:-

spleen:6.95

thymus:4.86

bone marrow:5.30

adipose:6.30

bone:-

skin:5.79

CAGE

cerebrum:1.47

cerebellum:-

brain stem:1.42

corpus callosum/glia:1.25

pineal gland:1.90

peripheral nerve:-

spine:1.11

retina:-

eye:-

artery/aorta:1.68

vein:1.44

lymphnode:1.60

peripheral blood:-

spleen:1.69

thymus:0.33

bone marrow:-

adipose:1.33

bone:-

skin:-

RNA-seq

cerebrum:2.21

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:2.51

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:0.79

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:82

placenta:29.10

prostate:135.20

ovary:-

testis:43.30

heart:63.90

muscle:-

esophagus:-

stomach:-

intestine:64.80

colon:25.40

liver/hepato:-

lung:44

bladder:-

kidney:72.80

pituitary:-

thyroid/parathyroid:-

adrenal gland:50.80

pancreas:35.60

breast:83.60

salivary:-

GeneChip

uterus:6.02

placenta:5.69

prostate:6.70

ovary:6.19

testis:6.76

heart:6.02

muscle:6.90

esophagus:6.40

stomach:6.22

intestine:6.51

colon:6.05

liver/hepato:6.35

lung:6.64

bladder:-

kidney:6.39

pituitary:6.79

thyroid/parathyroid:6.11

adrenal gland:6.78

pancreas:6.75

breast:6.39

salivary:6.51

CAGE

uterus:1.90

placenta:1.22

prostate:1.63

ovary:1.94

testis:2.10

heart:1.35

muscle:1.32

esophagus:1.56

stomach:-

intestine:1.79

colon:1.60

liver/hepato:1.33

lung:1.45

bladder:1.27

kidney:1.19

pituitary:2.14

thyroid/parathyroid:0.76

adrenal gland:-

pancreas:1.42

breast:1.53

salivary:1.49

RNA-seq

uterus:-

placenta:-

prostate:2.92

ovary:2.89

testis:2.51

heart:2.25

muscle:1.29

esophagus:-

stomach:-

intestine:-

colon:1.95

liver/hepato:2.31

lung:1.22

bladder:-

kidney:2.71

pituitary:-

thyroid/parathyroid:1.35

adrenal gland:3.19

pancreas:-

breast:2.64

salivary:-

IDs

Refseq ID	NM_000447
Gene ID	5664
Unigene ID	Hs.25363
Probe set ID	211373_s_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000143801
GTEx ID	ENSG00000143801

Orthologous Gene

Mouse[2]	NM_001128605, NM_011183
Rat [0]

Chromosomal Region

1q42.13 [227,057,885 - 227,083,806]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR006639	Peptidase A22, presenilin signal peptide
IPR001108	Peptidase A22A, presenilin
IPR001493	Peptidase A22A, presenilin 2

Gene Ontology (GO ID)

Biological Process

GO:0042987	amyloid precursor protein catabolic process
GO:0042640	anagen
GO:0050435	beta-amyloid metabolic process
GO:0048854	brain morphogenesis
GO:0006816	calcium ion transport
GO:0060048	cardiac muscle contraction
GO:0001708	cell fate specification
GO:0021904	dorsal/ventral neural tube patterning
GO:0030326	embryonic limb morphogenesis
GO:0032469	endoplasmic reticulum calcium ion homeostasis
GO:0030900	forebrain development
GO:0002244	hemopoietic progenitor cell differentiation
GO:0040011	locomotion
GO:0048286	lung alveolus development
GO:0006509	membrane protein ectodomain proteolysis
GO:0031293	membrane protein intracellular domain proteolysis
GO:0007613	memory
GO:0002573	myeloid leukocyte differentiation
GO:0043066	negative regulation of apoptosis
GO:0001933	negative regulation of protein amino acid phosphorylation
GO:0048011	nerve growth factor receptor signaling pathway
GO:0007220	Notch receptor processing
GO:0007219	Notch signaling pathway
GO:0043065	positive regulation of apoptosis
GO:0043085	positive regulation of catalytic activity
GO:0050820	positive regulation of coagulation
GO:0016485	protein processing
GO:0015031	protein transport
GO:0007176	regulation of epidermal growth factor receptor activity
GO:0043393	regulation of protein binding
GO:0048167	regulation of synaptic plasticity
GO:0001666	response to hypoxia
GO:0001756	somitogenesis
GO:0002286	T cell activation during immune response
GO:0050852	T cell receptor signaling pathway
GO:0048538	thymus development

Cellular Component

GO:0016324	apical plasma membrane
GO:0030424	axon
GO:0005938	cell cortex
GO:0043025	cell soma
GO:0009986	cell surface
GO:0005813	centrosome
GO:0035253	ciliary rootlet
GO:0005829	cytosol
GO:0043198	dendritic shaft
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005794	Golgi apparatus
GO:0000139	Golgi membrane
GO:0030426	growth cone
GO:0005887	integral to plasma membrane
GO:0000776	kinetochore
GO:0005765	lysosomal membrane
GO:0045121	membrane raft
GO:0005743	mitochondrial inner membrane
GO:0031594	neuromuscular junction
GO:0005637	nuclear inner membrane
GO:0048471	perinuclear region of cytoplasm
GO:0005886	plasma membrane
GO:0043234	protein complex
GO:0030018	Z disc

Molecular Function

GO:0004190	aspartic-type endopeptidase activity
GO:0004175	endopeptidase activity
GO:0005515	protein binding

presenilin 2 (Alzheimer disease 4)

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function