sphingosine kinase 2

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Synonym

sphingosine kinase 2, SK 2, SPK 2, SPHK2, Sphingosine kinase 2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:6.61 cerebellum:6.37 brain stem:6.90 corpus callosum/glia:6.53 pineal gland:- peripheral nerve:6.83 spine:6.66 retina:- eye:- artery/aorta:5.93 vein:5.60 lymphnode:6.03 peripheral blood:- spleen:5.95 thymus:5.80 bone marrow:5.72 adipose:6 bone:- skin:5.61
CAGE cerebrum:3.23 cerebellum:- brain stem:3.52 corpus callosum/glia:3.25 pineal gland:2.61 peripheral nerve:- spine:2.96 retina:- eye:- artery/aorta:2.39 vein:2.51 lymphnode:2.38 peripheral blood:- spleen:2.22 thymus:2.08 bone marrow:- adipose:2.05 bone:- skin:-
RNA-seq cerebrum:0.34 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.15 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.46 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:5.62 placenta:5.65 prostate:5.75 ovary:5.60 testis:6.85 heart:5.54 muscle:5.73 esophagus:5.67 stomach:5.99 intestine:6.09 colon:6.31 liver/hepato:6.76 lung:5.85 bladder:- kidney:7.04 pituitary:6.43 thyroid/parathyroid:6.34 adrenal gland:6.01 pancreas:5.60 breast:5.69 salivary:5.75
CAGE uterus:2.23 placenta:1.79 prostate:2.55 ovary:2.55 testis:3.40 heart:1.77 muscle:1.81 esophagus:1.98 stomach:- intestine:3.38 colon:3.14     liver/hepato:2.30    lung:2.15 bladder:2.00 kidney:3.00 pituitary:2.50 thyroid/parathyroid:2.79 adrenal gland:- pancreas:2.18 breast:1.92 salivary:2.43
RNA-seq uterus:- placenta:- prostate:0.65 ovary:0.50 testis:0.21 heart:0.27 muscle:0.00 esophagus:- stomach:- intestine:- colon:0.00     liver/hepato:0.06        lung:0.20    bladder:- kidney:0.31 pituitary:- thyroid/parathyroid:0.29 adrenal gland:0.57 pancreas:- breast:0.00 salivary:-

Gene Information

IDs

Refseq ID NM_020126
Gene ID 56848
Unigene ID -
Probe set ID 40273_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000063176
GTEx ID ENSG00000063176

Orthologous Gene

Mouse[4]  NM_001172561, NM_020011, NM_203280
Rat[1]  NM_001012066, NM_020011, NM_203280

Chromosomal Region

19q13.33  [49,122,548  -  49,133,973]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

10751414
11230166
11777919
12391145
12477932
14596938
14702039
15489334
15951439
16103110
16316995
16344560
16888242
17311928
17635916
17895250
17897319
18178871
18263879
19168031
19240026
19490468
19729656
20197547
20237496
21307639
21495716
21620961
21706498
21707492
21926972
23128233
23314175
23359503
23918304
24163370

Gene Ontology  (GO ID)

Biological Process

GO:0007205  activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway
GO:0001568  blood vessel development
GO:0007420  brain development
GO:0008283  cell proliferation
GO:0043066  negative regulation of apoptosis
GO:0008284  positive regulation of cell proliferation
GO:0006669  sphinganine-1-phosphate biosynthetic process
GO:0030148  sphingolipid biosynthetic process
GO:0006665  sphingolipid metabolic process
GO:0006670  sphingosine metabolic process

Cellular Component

GO:0005829  cytosol
GO:0005765  lysosomal membrane
GO:0016020  membrane

Molecular Function

GO:0005524  ATP binding
GO:0017050  D-erythro-sphingosine kinase activity
GO:0004143  diacylglycerol kinase activity
GO:0005515  protein binding
GO:0017016  Ras GTPase binding
GO:0008481  sphinganine kinase activity