proteasome (prosome, macropain) subunit, alpha type, 6

Synonym

PSMA6, MGC22756, IOTA, MGC2333, p27K, PROS-27, 27 kDa prosomal protein, Macropain iota chain, PROS27, Proteasome subunit alpha type 6, Proteasome iota chain, Multicatalytic endopeptidase complex iota chain, MGC23846

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:48.60

cerebellum:50.40

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:118.60

eye:141

artery/aorta:149.90

vein:133.30

lymphnode:60.70

peripheral blood:164

spleen:37.80

thymus:64.40

bone marrow:98.40

adipose:80.70

bone:38.40

skin:244.80

GeneChip

cerebrum:8.88

cerebellum:8.83

brain stem:8.97

corpus callosum/glia:8.63

pineal gland:-

peripheral nerve:9.25

spine:8.76

retina:-

eye:-

artery/aorta:8.83

vein:9.21

lymphnode:9.25

peripheral blood:-

spleen:9.28

thymus:10.82

bone marrow:9.13

adipose:9.29

bone:-

skin:9.56

CAGE

cerebrum:4.14

cerebellum:-

brain stem:4.10

corpus callosum/glia:3.67

pineal gland:4.19

peripheral nerve:-

spine:4.15

retina:-

eye:-

artery/aorta:3.60

vein:3.97

lymphnode:4.08

peripheral blood:-

spleen:4.09

thymus:4.93

bone marrow:-

adipose:4.16

bone:-

skin:-

RNA-seq

cerebrum:5.91

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:5.21

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:5.98

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:109.40

placenta:83.80

prostate:146.40

ovary:149.10

testis:95.20

heart:242.70

muscle:321.40

esophagus:-

stomach:106.20

intestine:-

colon:76.30

liver/hepato:105.60

lung:312.80

bladder:-

kidney:41.60

pituitary:347.90

thyroid/parathyroid:163.70

adrenal gland:101.60

pancreas:88.90

breast:185.90

salivary:-

GeneChip

uterus:9.36

placenta:9.61

prostate:9.54

ovary:9.41

testis:11.18

heart:9.28

muscle:10.06

esophagus:9.58

stomach:9.08

intestine:9.37

colon:9.14

liver/hepato:9.36

lung:9.66

bladder:-

kidney:8.92

pituitary:8.95

thyroid/parathyroid:8.94

adrenal gland:9.35

pancreas:9.08

breast:9.48

salivary:8.89

CAGE

uterus:4.13

placenta:4.68

prostate:3.63

ovary:4.11

testis:4.86

heart:4.25

muscle:4.84

esophagus:3.99

stomach:-

intestine:4.31

colon:4.14

liver/hepato:4.38

lung:4.12

bladder:3.87

kidney:4.47

pituitary:4.41

thyroid/parathyroid:3.86

adrenal gland:-

pancreas:4.14

breast:4.08

salivary:4.00

RNA-seq

uterus:-

placenta:-

prostate:5.20

ovary:5.77

testis:6.93

heart:5.32

muscle:6.70

esophagus:-

stomach:-

intestine:-

colon:5.71

liver/hepato:5.87

lung:5.91

bladder:-

kidney:5.76

pituitary:-

thyroid/parathyroid:6.29

adrenal gland:5.88

pancreas:-

breast:6.10

salivary:-

IDs

Refseq ID	NM_002791
Gene ID	5687
Unigene ID	Hs.446260
Probe set ID	208805_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000100902
GTEx ID	ENSG00000100902

Orthologous Gene

Mouse[2]	NM_011968
Rat [0]

Chromosomal Region

14q13.2 [35,747,839 - 35,786,699]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

Gene Ontology (GO ID)

Biological Process

GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0006915	apoptosis
GO:0034641	cellular nitrogen compound metabolic process
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0000082	G1/S transition of mitotic cell cycle
GO:0010467	gene expression
GO:0000278	mitotic cell cycle
GO:0016071	mRNA metabolic process
GO:0043066	negative regulation of apoptosis
GO:0051436	negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051437	positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle
GO:0000209	protein polyubiquitination
GO:0051603	proteolysis involved in cellular protein catabolic process
GO:0042981	regulation of apoptosis
GO:0006521	regulation of cellular amino acid metabolic process
GO:0050727	regulation of inflammatory response
GO:0051439	regulation of ubiquitin-protein ligase activity during mitotic cell cycle
GO:0016070	RNA metabolic process
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0016032	viral reproduction

Cellular Component

GO:0005737	cytoplasm
GO:0000932	cytoplasmic mRNA processing body
GO:0005829	cytosol
GO:0005739	mitochondrion
GO:0030016	myofibril
GO:0016363	nuclear matrix
GO:0005654	nucleoplasm
GO:0005634	nucleus
GO:0005844	polysome
GO:0005839	proteasome core complex
GO:0019773	proteasome core complex, alpha-subunit complex
GO:0030017	sarcomere

Molecular Function

GO:0004175	endopeptidase activity
GO:0051059	NF-kappaB binding
GO:0005515	protein binding
GO:0003723	RNA binding
GO:0004298	threonine-type endopeptidase activity

proteasome (prosome, macropain) subunit, alpha type, 6

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function