proteasome (prosome, macropain) subunit, beta type, 4

 jump to detail

Synonym

HsN3, Proteasome chain 3, Multicatalytic endopeptidase complex beta chain, Macropain beta chain, HsBPROS26, HSN3, Proteasome subunit beta type 4 precursor, Proteasome beta chain, HN3, PROS26, PSMB4

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:75.80 cerebellum:50.40 brain stem:- corpus callosum/glia:87.50 pineal gland:445 peripheral nerve:245.40 spine:- retina:474.60 eye:252.70 artery/aorta:329.70 vein:199.90 lymphnode:151.70 peripheral blood:200.40 spleen:170.20 thymus:206.10 bone marrow:78.70 adipose:121 bone:89.60 skin:86.40
GeneChip cerebrum:8.54 cerebellum:8.21 brain stem:8.92 corpus callosum/glia:8.07 pineal gland:- peripheral nerve:8.74 spine:8.37 retina:- eye:- artery/aorta:8.83 vein:8.53 lymphnode:8.71 peripheral blood:- spleen:8.65 thymus:9.14 bone marrow:8.24 adipose:8.77 bone:- skin:9.19
CAGE cerebrum:4.07 cerebellum:- brain stem:3.76 corpus callosum/glia:3.58 pineal gland:4.01 peripheral nerve:- spine:4.21 retina:- eye:- artery/aorta:4.66 vein:4.34 lymphnode:4.23 peripheral blood:- spleen:3.72 thymus:3.98 bone marrow:- adipose:3.79 bone:- skin:-
RNA-seq cerebrum:5.93 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:6.57 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:6.53 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:91.10 placenta:211.30 prostate:90.10 ovary:- testis:69.20 heart:204.30 muscle:80.40 esophagus:- stomach:42.50 intestine:97.20 colon:76.30     liver/hepato:126.70        lung:190.60    bladder:125.60 kidney:72.80 pituitary:232 thyroid/parathyroid:163.70 adrenal gland:50.80 pancreas:284.50 breast:111.50 salivary:328.40
GeneChip uterus:8.96 placenta:8.31 prostate:9.44 ovary:8.98 testis:8.19 heart:8.47 muscle:8.83 esophagus:8.59 stomach:8.41 intestine:8.62 colon:8.50 liver/hepato:8.72 lung:8.54 bladder:- kidney:8.80 pituitary:8.77 thyroid/parathyroid:8.75 adrenal gland:8.88 pancreas:8.28 breast:8.90 salivary:8.67
CAGE uterus:3.91 placenta:3.92 prostate:3.98 ovary:3.74 testis:3.81 heart:4.17 muscle:4.31 esophagus:4.22 stomach:- intestine:3.87 colon:4.25     liver/hepato:4.27    lung:3.98 bladder:4.29 kidney:4.20 pituitary:4.11 thyroid/parathyroid:3.97 adrenal gland:- pancreas:4.56 breast:4.28 salivary:3.82
RNA-seq uterus:- placenta:- prostate:6.95 ovary:6.68 testis:6.37 heart:5.83 muscle:6.29 esophagus:- stomach:- intestine:- colon:6.32     liver/hepato:6.84        lung:6.55    bladder:- kidney:6.97 pituitary:- thyroid/parathyroid:6.54 adrenal gland:6.74 pancreas:- breast:6.52 salivary:-

Gene Information

IDs

Refseq ID NM_002796
Gene ID 5692
Unigene ID Hs.89545
Probe set ID 202244_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000159377
GTEx ID ENSG00000159377

Orthologous Gene

Mouse[2]  NM_008945
Rat [0]  

Chromosomal Region

1q21.3  [151,372,010  -  151,374,420]

Gene Family (Interpro ID)

IPR016295  Proteasome endopeptidase complex, beta subunit
IPR001353  Proteasome, subunit alpha/beta

Link to Pubmed  (Pubmed ID)

1286667
2306472
7811265
7918633
8013624
8811196
9079628
9311996
9344661
9344905
9636170
9811770
9846577
10436176
10893419
11205743
11285280
11438941
11571290
12097147
12167863
12376572
12419264
12477932
12719574
12750511
12791267
12808465
12808466
12809610
12830140
12840737
12859895
12914693
12920286
12970355
14527406
14528300
14528301
14550573
14557625
14564014
14614829
15029244
15231748
15489334
15592455
15660529
15887188
16027165
16130169
16196087
16707496
17110338
17189198
17314511
17323924
17948026
18029348
18504423
18775730
18922472
19013454
19193609
19596235
19851296
20000738
20198315
20379614
20639865
20810900
21139048
21145461
21320693
21565611
21726808
21832049
21853274
21890473
21906983
21963094
21987572
21988832
22053931
22505724
22863883
22939629
23000965
23026050
23503661
23559827
23720494
23824909
24291262
24720748
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0031145  anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0042590  antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0002479  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002474  antigen processing and presentation of peptide antigen via MHC class I
GO:0006915  apoptosis
GO:0034641  cellular nitrogen compound metabolic process
GO:0006977  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0000082  G1/S transition of mitotic cell cycle
GO:0010467  gene expression
GO:0000278  mitotic cell cycle
GO:0016071  mRNA metabolic process
GO:0043066  negative regulation of apoptosis
GO:0002862  negative regulation of inflammatory response to antigenic stimulus
GO:0051436  negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle
GO:0051437  positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle
GO:0000209  protein polyubiquitination
GO:0042981  regulation of apoptosis
GO:0006521  regulation of cellular amino acid metabolic process
GO:0051439  regulation of ubiquitin-protein ligase activity during mitotic cell cycle
GO:0016070  RNA metabolic process
GO:0016032  viral reproduction
GO:0019048  virus-host interaction

Cellular Component

GO:0005829  cytosol
GO:0005654  nucleoplasm
GO:0005634  nucleus
GO:0000502  proteasome complex
GO:0005839  proteasome core complex

Molecular Function

GO:0001530  lipopolysaccharide binding
GO:0004298  threonine-type endopeptidase activity