patched homolog 1 (Drosophila)

Synonym

PTCH1, PTC1, NBCCS, patched homolog (Drosophila), Protein patched homolog 1, patched (Drosophila) homolog, FLJ42602, patched homolog 1 (Drosophila), BCNS, HPE7, PTCH

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:21.30

cerebellum:151.10

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:92

spine:-

retina:-

eye:64.60

artery/aorta:-

vein:-

lymphnode:10.10

peripheral blood:-

spleen:18.90

thymus:12.90

bone marrow:-

adipose:-

bone:-

skin:24

GeneChip

cerebrum:6.38

cerebellum:8.31

brain stem:6.62

corpus callosum/glia:6.27

pineal gland:-

peripheral nerve:9.20

spine:6.21

retina:-

eye:-

artery/aorta:5.95

vein:4.75

lymphnode:5.38

peripheral blood:-

spleen:5.79

thymus:4.36

bone marrow:3.81

adipose:5.27

bone:-

skin:5.60

CAGE

cerebrum:1.95

cerebellum:-

brain stem:2.14

corpus callosum/glia:2.26

pineal gland:1.65

peripheral nerve:-

spine:2.12

retina:-

eye:-

artery/aorta:2.02

vein:1.23

lymphnode:1.61

peripheral blood:-

spleen:1.67

thymus:0.80

bone marrow:-

adipose:1.12

bone:-

skin:-

RNA-seq

cerebrum:0.15

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:0.25

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:0.10

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:9.10

placenta:14.60

prostate:11.30

ovary:-

testis:86.50

heart:25.50

muscle:-

esophagus:-

stomach:-

intestine:-

colon:33.90

liver/hepato:-

lung:19.60

bladder:-

kidney:31.20

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:35.60

breast:9.30

salivary:-

GeneChip

uterus:7.30

placenta:5.34

prostate:7.60

ovary:6.73

testis:7.39

heart:5.07

muscle:4.66

esophagus:4.56

stomach:7.52

intestine:6.69

colon:7.46

liver/hepato:4.85

lung:6.45

bladder:-

kidney:5.93

pituitary:6.76

thyroid/parathyroid:6.85

adrenal gland:6.91

pancreas:4.89

breast:5.54

salivary:6.25

CAGE

uterus:2.57

placenta:1.11

prostate:1.88

ovary:1.29

testis:2.70

heart:1.40

muscle:0.95

esophagus:1.48

stomach:-

intestine:2.23

colon:2.92

liver/hepato:0.78

lung:2.13

bladder:1.45

kidney:1.48

pituitary:1.42

thyroid/parathyroid:1.96

adrenal gland:-

pancreas:2.54

breast:2.27

salivary:2.43

RNA-seq

uterus:-

placenta:-

prostate:0.20

ovary:0

testis:0.87

heart:0.11

muscle:0.06

esophagus:-

stomach:-

intestine:-

colon:0.17

liver/hepato:0.07

lung:0.12

bladder:-

kidney:0.10

pituitary:-

thyroid/parathyroid:0.35

adrenal gland:0.20

pancreas:-

breast:0.10

salivary:-

IDs

Refseq ID	NM_000264
Gene ID	5727
Unigene ID	Hs.494538
Probe set ID	209815_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000185920
GTEx ID	ENSG00000185920

Orthologous Gene

Mouse[1]	NM_008957
Rat [0]

Chromosomal Region

9q22.32 [98,205,262 - 98,279,339]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR003392	Patched
IPR004766	Transmembrane receptor, patched

Gene Ontology (GO ID)

Biological Process

GO:0007420	brain development
GO:0001658	branching involved in ureteric bud morphogenesis
GO:0071397	cellular response to cholesterol
GO:0009953	dorsal/ventral pattern formation
GO:0030326	embryonic limb morphogenesis
GO:0008544	epidermis development
GO:0042593	glucose homeostasis
GO:0003007	heart morphogenesis
GO:0035137	hindlimb morphogenesis
GO:0043616	keratinocyte proliferation
GO:0035108	limb morphogenesis
GO:0060603	mammary gland duct morphogenesis
GO:0060644	mammary gland epithelial cell differentiation
GO:0051782	negative regulation of cell division
GO:0050680	negative regulation of epithelial cell proliferation
GO:0040015	negative regulation of multicellular organism growth
GO:0045668	negative regulation of osteoblast differentiation
GO:0045879	negative regulation of smoothened signaling pathway
GO:0043433	negative regulation of transcription factor activity
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0021997	neural plate axis specification
GO:0001843	neural tube closure
GO:0021532	neural tube patterning
GO:0009887	organ morphogenesis
GO:0060037	pharyngeal system development
GO:0010875	positive regulation of cholesterol efflux
GO:0016485	protein processing
GO:0007346	regulation of mitotic cell cycle
GO:0032880	regulation of protein localization
GO:0008589	regulation of smoothened signaling pathway
GO:0010157	response to chlorate
GO:0007224	smoothened signaling pathway
GO:0060831	smoothened signaling pathway involved in dorsal/ventral neural tube patterning
GO:0021522	spinal cord motor neuron differentiation

Cellular Component

GO:0005901	caveola
GO:0005794	Golgi apparatus
GO:0016021	integral to membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0030496	midbody
GO:0048471	perinuclear region of cytoplasm
GO:0005886	plasma membrane

Molecular Function

GO:0015485	cholesterol binding
GO:0030332	cyclin binding
GO:0008158	hedgehog receptor activity
GO:0008201	heparin binding
GO:0005113	patched binding
GO:0005515	protein binding
GO:0032403	protein complex binding
GO:0005119	smoothened binding

patched homolog 1 (Drosophila)

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function