prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)

Synonym

PCOX1, Prostaglandin-endoperoxide synthase 1, PHS1, PGHS1, COX1, PTGS1, PGH synthase 1, Prostaglandin H2 synthase 1, COX-1, Prostaglandin G/H synthase 1 precursor, Cyclooxygenase-1, PGHS-1, PGG/HS, PTGHS, PHS 1, COX3

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:23.70

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:148.30

peripheral nerve:-

spine:224.60

retina:-

eye:29.40

artery/aorta:60

vein:66.60

lymphnode:40.40

peripheral blood:36.40

spleen:56.70

thymus:12.90

bone marrow:-

adipose:-

bone:12.80

skin:120

GeneChip

cerebrum:5.58

cerebellum:5.26

brain stem:5.78

corpus callosum/glia:6.11

pineal gland:-

peripheral nerve:5.77

spine:6.21

retina:-

eye:-

artery/aorta:6.16

vein:5.97

lymphnode:6.09

peripheral blood:-

spleen:5.94

thymus:5.10

bone marrow:6.25

adipose:6.19

bone:-

skin:7.77

CAGE

cerebrum:2.50

cerebellum:-

brain stem:3.08

corpus callosum/glia:3.55

pineal gland:5.10

peripheral nerve:-

spine:3.25

retina:-

eye:-

artery/aorta:3.52

vein:3.36

lymphnode:2.95

peripheral blood:-

spleen:3.30

thymus:1.49

bone marrow:-

adipose:2.84

bone:-

skin:-

RNA-seq

cerebrum:1.52

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:2.35

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:0.83

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:18.20

placenta:-

prostate:135.20

ovary:37.30

testis:4.30

heart:38.30

muscle:-

esophagus:-

stomach:42.50

intestine:32.40

colon:25.40

liver/hepato:-

lung:34.20

bladder:-

kidney:10.40

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:17.80

breast:9.30

salivary:-

GeneChip

uterus:5.95

placenta:5.46

prostate:5.62

ovary:6.47

testis:4.71

heart:6.14

muscle:5.64

esophagus:7.15

stomach:7.17

intestine:6.54

colon:7.03

liver/hepato:5.63

lung:6.35

bladder:-

kidney:5.80

pituitary:5.82

thyroid/parathyroid:5.61

adrenal gland:5.50

pancreas:5.93

breast:6.52

salivary:5.49

CAGE

uterus:3.06

placenta:2.07

prostate:6.10

ovary:3.31

testis:2.07

heart:3.08

muscle:1.58

esophagus:4.94

stomach:-

intestine:3.78

colon:5.02

liver/hepato:2.53

lung:3.26

bladder:7.05

kidney:2.76

pituitary:3.22

thyroid/parathyroid:1.73

adrenal gland:-

pancreas:1.42

breast:2.91

salivary:2.43

RNA-seq

uterus:-

placenta:-

prostate:7.60

ovary:2.09

testis:1.81

heart:1.02

muscle:0.52

esophagus:-

stomach:-

intestine:-

colon:4.68

liver/hepato:0.16

lung:2.72

bladder:-

kidney:2.33

pituitary:-

thyroid/parathyroid:1.35

adrenal gland:2.33

pancreas:-

breast:1.49

salivary:-

IDs

Refseq ID	NM_000962
Gene ID	5742
Unigene ID	Hs.201978
Probe set ID	205128_x_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000095303
GTEx ID	ENSG00000095303

Orthologous Gene

Mouse[2]	NM_008969
Rat [0]

Chromosomal Region

9q33.2 [125,132,824 - 125,157,982]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR000742	EGF-like, type 3
IPR010255	Haem peroxidase
IPR002007	Haem peroxidase, animal
IPR019791	Haem peroxidase, animal, subgroup

Gene Ontology (GO ID)

Biological Process

GO:0019369	arachidonic acid metabolic process
GO:0019371	cyclooxygenase pathway
GO:0006629	lipid metabolic process
GO:0001516	prostaglandin biosynthetic process
GO:0008217	regulation of blood pressure
GO:0042127	regulation of cell proliferation
GO:0006979	response to oxidative stress
GO:0006805	xenobiotic metabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0005789	endoplasmic reticulum membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0005634	nucleus
GO:0001750	photoreceptor outer segment

Molecular Function

GO:0020037	heme binding
GO:0046872	metal ion binding
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0004601	peroxidase activity
GO:0004666	prostaglandin-endoperoxide synthase activity

prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function