PTK2 protein tyrosine kinase 2

Synonym

PTK2 protein tyrosine kinase 2, pp125FAK, FADK 1, PTK2, FAK1, FADK, Focal adhesion kinase 1, FAK, Protein-tyrosine kinase 2

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:315.30

cerebellum:251.90

brain stem:-

corpus callosum/glia:379.10

pineal gland:296.70

peripheral nerve:276

spine:112.30

retina:118.60

eye:123.40

artery/aorta:30

vein:66.60

lymphnode:111.20

peripheral blood:18.20

spleen:56.70

thymus:116

bone marrow:78.70

adipose:121

bone:102.40

skin:297.60

GeneChip

cerebrum:8.48

cerebellum:7.45

brain stem:8.43

corpus callosum/glia:9.21

pineal gland:-

peripheral nerve:7.45

spine:8.41

retina:-

eye:-

artery/aorta:8.01

vein:8

lymphnode:6.84

peripheral blood:-

spleen:6.89

thymus:5.58

bone marrow:5.14

adipose:7.52

bone:-

skin:6.94

CAGE

cerebrum:4.61

cerebellum:-

brain stem:4.75

corpus callosum/glia:5.18

pineal gland:4.22

peripheral nerve:-

spine:4.59

retina:-

eye:-

artery/aorta:4.49

vein:3.78

lymphnode:3.16

peripheral blood:-

spleen:3.20

thymus:2.28

bone marrow:-

adipose:4.00

bone:-

skin:-

RNA-seq

cerebrum:3.76

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:3.38

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:4.17

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:109.40

placenta:163.90

prostate:101.40

ovary:708

testis:255.30

heart:191.60

muscle:20.10

esophagus:-

stomach:148.70

intestine:97.20

colon:483.30

liver/hepato:126.70

lung:195.50

bladder:-

kidney:104

pituitary:232

thyroid/parathyroid:163.70

adrenal gland:152.40

pancreas:142.30

breast:297.40

salivary:-

GeneChip

uterus:7.77

placenta:7.84

prostate:7.92

ovary:7.70

testis:7.94

heart:7.35

muscle:6.91

esophagus:6.75

stomach:7.37

intestine:7.37

colon:7.09

liver/hepato:6.69

lung:7.61

bladder:-

kidney:7.57

pituitary:6.63

thyroid/parathyroid:7.75

adrenal gland:7.71

pancreas:6.51

breast:7.59

salivary:7.57

CAGE

uterus:4.13

placenta:4.11

prostate:3.71

ovary:3.61

testis:4.03

heart:3.90

muscle:3.47

esophagus:3.52

stomach:-

intestine:3.78

colon:3.92

liver/hepato:3.21

lung:3.88

bladder:3.87

kidney:3.75

pituitary:3.82

thyroid/parathyroid:3.64

adrenal gland:-

pancreas:3.84

breast:4.18

salivary:3.89

RNA-seq

uterus:-

placenta:-

prostate:4.58

ovary:4.42

testis:4.71

heart:3.62

muscle:4.09

esophagus:-

stomach:-

intestine:-

colon:4.50

liver/hepato:2.62

lung:4.58

bladder:-

kidney:3.94

pituitary:-

thyroid/parathyroid:4.27

adrenal gland:2.61

pancreas:-

breast:2.95

salivary:-

IDs

Refseq ID	NM_153831
Gene ID	5747
Unigene ID	Hs.395482
Probe set ID	208820_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000169398
GTEx ID	ENSG00000169398

Orthologous Gene

Mouse[3]	NM_001130409, NM_007982
Rat [0]

Chromosomal Region

8q24.3 [141,667,999 - 142,012,315]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR019749	Band 4.1 domain
IPR000719	Protein kinase, catalytic domain
IPR011009	Protein kinase-like domain
IPR002290	Serine/threonine-protein kinase domain
IPR017442	Serine/threonine-protein kinase-like domain
IPR001245	Tyrosine-protein kinase, catalytic domain
IPR020635	Tyrosine-protein kinase, subgroup, catalytic domain

Gene Ontology (GO ID)

Biological Process

GO:0001525	angiogenesis
GO:0006915	apoptosis
GO:0007411	axon guidance
GO:0007596	blood coagulation
GO:0048870	cell motility
GO:0006921	cell structure disassembly during apoptosis
GO:0030644	cellular chloride ion homeostasis
GO:0021955	central nervous system neuron axonogenesis
GO:0009790	embryonic development
GO:0043542	endothelial cell migration
GO:0048013	ephrin receptor signaling pathway
GO:0030010	establishment of cell polarity
GO:0040023	establishment of nucleus localization
GO:0030198	extracellular matrix organization
GO:0045444	fat cell differentiation
GO:0060396	growth hormone receptor signaling pathway
GO:0003007	heart morphogenesis
GO:0045087	innate immune response
GO:0007229	integrin-mediated signaling pathway
GO:0007254	JNK cascade
GO:0000226	microtubule cytoskeleton organization
GO:0043066	negative regulation of apoptosis
GO:0050771	negative regulation of axonogenesis
GO:0030336	negative regulation of cell migration
GO:0022408	negative regulation of cell-cell adhesion
GO:0046621	negative regulation of organ growth
GO:0051964	negative regulation of synaptogenesis
GO:0001764	neuron migration
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0001890	placenta development
GO:0030168	platelet activation
GO:0045785	positive regulation of cell adhesion
GO:0030307	positive regulation of cell growth
GO:0030335	positive regulation of cell migration
GO:0008284	positive regulation of cell proliferation
GO:0060252	positive regulation of glial cell proliferation
GO:0050766	positive regulation of phagocytosis
GO:0043552	positive regulation of phosphoinositide 3-kinase activity
GO:0014068	positive regulation of phosphoinositide 3-kinase cascade
GO:0001934	positive regulation of protein amino acid phosphorylation
GO:0045860	positive regulation of protein kinase activity
GO:0051897	positive regulation of protein kinase B signaling cascade
GO:0014911	positive regulation of smooth muscle cell migration
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0050806	positive regulation of synaptic transmission
GO:0045909	positive regulation of vasodilation
GO:0046777	protein amino acid autophosphorylation
GO:0033628	regulation of cell adhesion mediated by integrin
GO:0042127	regulation of cell proliferation
GO:0008360	regulation of cell shape
GO:0051493	regulation of cytoskeleton organization
GO:0010594	regulation of endothelial cell migration
GO:0051893	regulation of focal adhesion formation
GO:0045667	regulation of osteoblast differentiation
GO:0032319	regulation of Rho GTPase activity
GO:0046685	response to arsenic
GO:0042493	response to drug
GO:0032355	response to estradiol stimulus
GO:0009749	response to glucose stimulus
GO:0009612	response to mechanical stimulus
GO:0007172	signal complex assembly
GO:0001570	vasculogenesis

Cellular Component

GO:0016324	apical plasma membrane
GO:0016323	basolateral plasma membrane
GO:0005938	cell cortex
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005829	cytosol
GO:0005925	focal adhesion
GO:0014704	intercalated disc
GO:0030027	lamellipodium
GO:0005815	microtubule organizing center
GO:0016604	nuclear body
GO:0005730	nucleolus
GO:0005634	nucleus
GO:0042383	sarcolemma

Molecular Function

GO:0003779	actin binding
GO:0005524	ATP binding
GO:0005178	integrin binding
GO:0008432	JUN kinase binding
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0043548	phosphoinositide 3-kinase binding
GO:0005515	protein binding
GO:0004672	protein kinase activity
GO:0019901	protein kinase binding
GO:0042169	SH2 domain binding
GO:0004871	signal transducer activity

PTK2 protein tyrosine kinase 2

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function