PTK2 protein tyrosine kinase 2

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Synonym

PTK2 protein tyrosine kinase 2, pp125FAK, FADK 1, PTK2, FAK1, FADK, Focal adhesion kinase 1, FAK, Protein-tyrosine kinase 2

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:315.30 cerebellum:251.90 brain stem:- corpus callosum/glia:379.10 pineal gland:296.70 peripheral nerve:276 spine:112.30 retina:118.60 eye:123.40 artery/aorta:30 vein:66.60 lymphnode:111.20 peripheral blood:18.20 spleen:56.70 thymus:116 bone marrow:78.70 adipose:121 bone:102.40 skin:297.60
GeneChip cerebrum:8.48 cerebellum:7.45 brain stem:8.43 corpus callosum/glia:9.21 pineal gland:- peripheral nerve:7.45 spine:8.41 retina:- eye:- artery/aorta:8.01 vein:8 lymphnode:6.84 peripheral blood:- spleen:6.89 thymus:5.58 bone marrow:5.14 adipose:7.52 bone:- skin:6.94
CAGE cerebrum:4.61 cerebellum:- brain stem:4.75 corpus callosum/glia:5.18 pineal gland:4.22 peripheral nerve:- spine:4.59 retina:- eye:- artery/aorta:4.49 vein:3.78 lymphnode:3.16 peripheral blood:- spleen:3.20 thymus:2.28 bone marrow:- adipose:4.00 bone:- skin:-
RNA-seq cerebrum:3.76 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.38 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:4.17 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:109.40 placenta:163.90 prostate:101.40 ovary:708 testis:255.30 heart:191.60 muscle:20.10 esophagus:- stomach:148.70 intestine:97.20 colon:483.30     liver/hepato:126.70        lung:195.50    bladder:- kidney:104 pituitary:232 thyroid/parathyroid:163.70 adrenal gland:152.40 pancreas:142.30 breast:297.40 salivary:-
GeneChip uterus:7.77 placenta:7.84 prostate:7.92 ovary:7.70 testis:7.94 heart:7.35 muscle:6.91 esophagus:6.75 stomach:7.37 intestine:7.37 colon:7.09 liver/hepato:6.69 lung:7.61 bladder:- kidney:7.57 pituitary:6.63 thyroid/parathyroid:7.75 adrenal gland:7.71 pancreas:6.51 breast:7.59 salivary:7.57
CAGE uterus:4.13 placenta:4.11 prostate:3.71 ovary:3.61 testis:4.03 heart:3.90 muscle:3.47 esophagus:3.52 stomach:- intestine:3.78 colon:3.92     liver/hepato:3.21    lung:3.88 bladder:3.87 kidney:3.75 pituitary:3.82 thyroid/parathyroid:3.64 adrenal gland:- pancreas:3.84 breast:4.18 salivary:3.89
RNA-seq uterus:- placenta:- prostate:4.58 ovary:4.42 testis:4.71 heart:3.62 muscle:4.09 esophagus:- stomach:- intestine:- colon:4.50     liver/hepato:2.62        lung:4.58    bladder:- kidney:3.94 pituitary:- thyroid/parathyroid:4.27 adrenal gland:2.61 pancreas:- breast:2.95 salivary:-

IDs

Refseq ID NM_153831
Gene ID 5747
Unigene ID Hs.395482
Probe set ID 208820_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000169398
GTEx ID ENSG00000169398

Orthologous Gene

Mouse[3]  NM_001130409, NM_007982
Rat [0]  

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed  (Pubmed ID)

7479864
7509446
7515480
7529872
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Gene Ontology  (GO ID)

Biological Process

GO:0001525  angiogenesis
GO:0006915  apoptosis
GO:0007411  axon guidance
GO:0007596  blood coagulation
GO:0048870  cell motility
GO:0006921  cell structure disassembly during apoptosis
GO:0030644  cellular chloride ion homeostasis
GO:0021955  central nervous system neuron axonogenesis
GO:0009790  embryonic development
GO:0043542  endothelial cell migration
GO:0048013  ephrin receptor signaling pathway
GO:0030010  establishment of cell polarity
GO:0040023  establishment of nucleus localization
GO:0030198  extracellular matrix organization
GO:0045444  fat cell differentiation
GO:0060396  growth hormone receptor signaling pathway
GO:0003007  heart morphogenesis
GO:0045087  innate immune response
GO:0007229  integrin-mediated signaling pathway
GO:0007254  JNK cascade
GO:0000226  microtubule cytoskeleton organization
GO:0043066  negative regulation of apoptosis
GO:0050771  negative regulation of axonogenesis
GO:0030336  negative regulation of cell migration
GO:0022408  negative regulation of cell-cell adhesion
GO:0046621  negative regulation of organ growth
GO:0051964  negative regulation of synaptogenesis
GO:0001764  neuron migration
GO:0018108  peptidyl-tyrosine phosphorylation
GO:0001890  placenta development
GO:0030168  platelet activation
GO:0045785  positive regulation of cell adhesion
GO:0030307  positive regulation of cell growth
GO:0030335  positive regulation of cell migration
GO:0008284  positive regulation of cell proliferation
GO:0060252  positive regulation of glial cell proliferation
GO:0050766  positive regulation of phagocytosis
GO:0043552  positive regulation of phosphoinositide 3-kinase activity
GO:0014068  positive regulation of phosphoinositide 3-kinase cascade
GO:0001934  positive regulation of protein amino acid phosphorylation
GO:0045860  positive regulation of protein kinase activity
GO:0051897  positive regulation of protein kinase B signaling cascade
GO:0014911  positive regulation of smooth muscle cell migration
GO:0048661  positive regulation of smooth muscle cell proliferation
GO:0050806  positive regulation of synaptic transmission
GO:0045909  positive regulation of vasodilation
GO:0046777  protein amino acid autophosphorylation
GO:0033628  regulation of cell adhesion mediated by integrin
GO:0042127  regulation of cell proliferation
GO:0008360  regulation of cell shape
GO:0051493  regulation of cytoskeleton organization
GO:0010594  regulation of endothelial cell migration
GO:0051893  regulation of focal adhesion formation
GO:0045667  regulation of osteoblast differentiation
GO:0032319  regulation of Rho GTPase activity
GO:0046685  response to arsenic
GO:0042493  response to drug
GO:0032355  response to estradiol stimulus
GO:0009749  response to glucose stimulus
GO:0009612  response to mechanical stimulus
GO:0007172  signal complex assembly
GO:0001570  vasculogenesis

Cellular Component

GO:0016324  apical plasma membrane
GO:0016323  basolateral plasma membrane
GO:0005938  cell cortex
GO:0005737  cytoplasm
GO:0005856  cytoskeleton
GO:0005829  cytosol
GO:0005925  focal adhesion
GO:0014704  intercalated disc
GO:0030027  lamellipodium
GO:0005815  microtubule organizing center
GO:0016604  nuclear body
GO:0005730  nucleolus
GO:0005634  nucleus
GO:0042383  sarcolemma

Molecular Function

GO:0003779  actin binding
GO:0005524  ATP binding
GO:0005178  integrin binding
GO:0008432  JUN kinase binding
GO:0004715  non-membrane spanning protein tyrosine kinase activity
GO:0043548  phosphoinositide 3-kinase binding
GO:0005515  protein binding
GO:0004672  protein kinase activity
GO:0019901  protein kinase binding
GO:0042169  SH2 domain binding
GO:0004871  signal transducer activity