MKL/myocardin-like 2

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Synonym

MRTF-B, MKL/myocardin-like 2, DKFZp686J1745, FLJ45623, MKL2, FLJ31823, NPD001, Myocardin-related transcription factor B, Megakaryoblastic leukemia 2, KIAA1243, MKL/myocardin-like protein 2, MRTFB

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:12.80 skin:-
GeneChip cerebrum:8.16 cerebellum:5.78 brain stem:6.22 corpus callosum/glia:6.42 pineal gland:- peripheral nerve:6.44 spine:6.57 retina:- eye:- artery/aorta:7.37 vein:7.25 lymphnode:7.10 peripheral blood:- spleen:6.35 thymus:7.37 bone marrow:4.80 adipose:7.95 bone:- skin:7.84
CAGE cerebrum:4.61 cerebellum:- brain stem:3.74 corpus callosum/glia:3.35 pineal gland:4.25 peripheral nerve:- spine:3.92 retina:- eye:- artery/aorta:3.56 vein:3.26 lymphnode:3.16 peripheral blood:- spleen:3.03 thymus:2.67 bone marrow:- adipose:4.44 bone:- skin:-
RNA-seq cerebrum:4.55 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.64 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.66 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:10.40 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:8.90 breast:- salivary:-
GeneChip uterus:8.05 placenta:7.98 prostate:8.48 ovary:7.56 testis:7.89 heart:7.02 muscle:7.40 esophagus:7.24 stomach:7.36 intestine:7.24 colon:6.81 liver/hepato:6.81 lung:7.59 bladder:- kidney:6.75 pituitary:7.59 thyroid/parathyroid:7.85 adrenal gland:7.17 pancreas:6.55 breast:8.33 salivary:6.77
CAGE uterus:4.19 placenta:4.13 prostate:3.93 ovary:3.55 testis:3.70 heart:3.48 muscle:2.92 esophagus:3.67 stomach:- intestine:3.51 colon:3.03     liver/hepato:3.56    lung:3.79 bladder:3.72 kidney:3.60 pituitary:4.29 thyroid/parathyroid:3.82 adrenal gland:- pancreas:3.42 breast:3.35 salivary:3.48
RNA-seq uterus:- placenta:- prostate:2.78 ovary:3.16 testis:3.25 heart:2.69 muscle:2.30 esophagus:- stomach:- intestine:- colon:2.70     liver/hepato:1.49        lung:3.08    bladder:- kidney:2.49 pituitary:- thyroid/parathyroid:2.88 adrenal gland:3.87 pancreas:- breast:3.73 salivary:-

Gene Information

IDs

Refseq ID NM_014048
Gene ID 57496
Unigene ID Hs.49143
Probe set ID 218259_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000186260
GTEx ID ENSG00000186260

Orthologous Gene

Mouse[3]  NM_001122667, NM_153588, NM_181860
Rat[3]  NM_001122667, NM_153588, NM_181860

Chromosomal Region

16p13.12  [14,173,145  -  14,360,629]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

10574462
12168954
12397177
12477932
12944485
14565952
14702039
15231748
15489334
17081983
17360478
17947237
17991879
18029348
18056415
19198601
20309963
20442744
20607705
20881960
21102462
22139079
23672313
23853104
24250222

Gene Ontology  (GO ID)

Biological Process

GO:0048514  blood vessel morphogenesis
GO:0048738  cardiac muscle tissue development
GO:0048568  embryonic organ development
GO:0003007  heart morphogenesis
GO:0001701  in utero embryonic development
GO:0001889  liver development
GO:0007517  muscle organ development
GO:0045844  positive regulation of striated muscle tissue development
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0051145  smooth muscle cell differentiation
GO:0006351  transcription, DNA-dependent

Cellular Component

GO:0005737  cytoplasm
GO:0005634  nucleus

Molecular Function

GO:0003779  actin binding
GO:0003676  nucleic acid binding
GO:0005515  protein binding
GO:0003713  transcription coactivator activity
GO:0003700  transcription factor activity