protein tyrosine phosphatase, non-receptor type 1

Synonym

PTPN1, PTP1B, PTP-1B, Tyrosine-protein phosphatase non-receptor type 1, protein tyrosine phosphatase, non-receptor type 1, Protein-tyrosine phosphatase 1B

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:84.10

cerebellum:75.60

brain stem:-

corpus callosum/glia:175

pineal gland:-

peripheral nerve:-

spine:112.30

retina:-

eye:58.80

artery/aorta:119.90

vein:-

lymphnode:121.30

peripheral blood:145.70

spleen:151.30

thymus:463.80

bone marrow:78.70

adipose:40.30

bone:140.70

skin:57.60

GeneChip

cerebrum:6.35

cerebellum:6.11

brain stem:6.32

corpus callosum/glia:6.44

pineal gland:-

peripheral nerve:6.68

spine:6.53

retina:-

eye:-

artery/aorta:6.96

vein:6.44

lymphnode:7.75

peripheral blood:-

spleen:7.94

thymus:7.21

bone marrow:6.82

adipose:6.69

bone:-

skin:6.66

CAGE

cerebrum:3.94

cerebellum:-

brain stem:3.87

corpus callosum/glia:4.23

pineal gland:4.15

peripheral nerve:-

spine:4.22

retina:-

eye:-

artery/aorta:4.32

vein:4.63

lymphnode:4.68

peripheral blood:-

spleen:5.04

thymus:4.37

bone marrow:-

adipose:4.40

bone:-

skin:-

RNA-seq

cerebrum:3.31

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:4.51

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:3.95

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:136.70

placenta:156.70

prostate:112.60

ovary:37.30

testis:151.40

heart:51.10

muscle:20.10

esophagus:-

stomach:21.20

intestine:97.20

colon:93.30

liver/hepato:52.80

lung:127.10

bladder:125.60

kidney:176.80

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:35.60

breast:120.80

salivary:-

GeneChip

uterus:6.75

placenta:6.95

prostate:7.27

ovary:6.82

testis:7.14

heart:6.78

muscle:6.62

esophagus:7.24

stomach:7.08

intestine:6.30

colon:6.88

liver/hepato:6.88

lung:7.49

bladder:-

kidney:7.11

pituitary:6.85

thyroid/parathyroid:7.19

adrenal gland:7.26

pancreas:5.84

breast:7.10

salivary:6.56

CAGE

uterus:4.29

placenta:4.51

prostate:4.08

ovary:4.01

testis:4.36

heart:4.05

muscle:4.72

esophagus:4.11

stomach:-

intestine:3.94

colon:3.94

liver/hepato:3.88

lung:4.75

bladder:4.29

kidney:4.99

pituitary:4.23

thyroid/parathyroid:3.80

adrenal gland:-

pancreas:3.47

breast:3.16

salivary:3.83

RNA-seq

uterus:-

placenta:-

prostate:3.74

ovary:3.82

testis:3.77

heart:3.79

muscle:2.99

esophagus:-

stomach:-

intestine:-

colon:3.24

liver/hepato:2.99

lung:4.84

bladder:-

kidney:4.83

pituitary:-

thyroid/parathyroid:4.44

adrenal gland:4.70

pancreas:-

breast:3.29

salivary:-

IDs

Refseq ID	NM_002827
Gene ID	5770
Unigene ID	Hs.417549
Probe set ID	202716_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000196396
GTEx ID	ENSG00000196396

Orthologous Gene

Mouse[2]	NM_011201
Rat [0]

Chromosomal Region

20q13.13 [49,126,891 - 49,201,299]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR000242

Protein-tyrosine phosphatase, receptor/non-receptor type

Gene Ontology (GO ID)

Biological Process

GO:0031532	actin cytoskeleton reorganization
GO:0007596	blood coagulation
GO:0019221	cytokine-mediated signaling pathway
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0008286	insulin receptor signaling pathway
GO:0060333	interferon-gamma-mediated signaling pathway
GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway
GO:0046627	negative regulation of insulin receptor signaling pathway
GO:0030168	platelet activation
GO:0030100	regulation of endocytosis
GO:0060334	regulation of interferon-gamma-mediated signaling pathway
GO:0009966	regulation of signal transduction
GO:0060338	regulation of type I interferon-mediated signaling pathway
GO:0060337	type I interferon-mediated signaling pathway

Cellular Component

GO:0031410	cytoplasmic vesicle
GO:0005829	cytosol
GO:0005769	early endosome
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane

Molecular Function

GO:0019899	enzyme binding
GO:0046875	ephrin receptor binding
GO:0005158	insulin receptor binding
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0004725	protein tyrosine phosphatase activity
GO:0030971	receptor tyrosine kinase binding
GO:0008270	zinc ion binding

protein tyrosine phosphatase, non-receptor type 1

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function