spectrin, beta, non-erythrocytic 4

 jump to detail

Synonym

KIAA1642, Spectrin beta chain, brain 3, SPTBN3, Spectrin, non-erythroid beta chain 3, SPNB4, spectrin, beta, non-erythrocytic 4, SPTBN4, QV, Beta-IV spectrin

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:19 cerebellum:88.20 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:112.30 retina:118.60 eye:29.40 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip nodata
CAGE cerebrum:3.70 cerebellum:- brain stem:2.72 corpus callosum/glia:2.18 pineal gland:3.63 peripheral nerve:- spine:2.28 retina:- eye:- artery/aorta:1.03 vein:0.70 lymphnode:0.19 peripheral blood:- spleen:0.09 thymus:0 bone marrow:- adipose:0.71 bone:- skin:-
RNA-seq cerebrum:2.07 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.02 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.15 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:3.60 prostate:11.30 ovary:- testis:4.30 heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:10.60        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:62.20 breast:- salivary:-
GeneChip nodata
CAGE uterus:1.45 placenta:0.16 prostate:1.36 ovary:1.44 testis:1.43 heart:0.82 muscle:0.21 esophagus:0.57 stomach:- intestine:0.14 colon:0.69     liver/hepato:0.14    lung:0 bladder:0.98 kidney:0.44 pituitary:3.19 thyroid/parathyroid:0.41 adrenal gland:- pancreas:0.58 breast:0 salivary:0.62
RNA-seq uterus:- placenta:- prostate:0.33 ovary:0.55 testis:0.71 heart:0.12 muscle:0.00 esophagus:- stomach:- intestine:- colon:0.31     liver/hepato:0.00        lung:0.00    bladder:- kidney:0.13 pituitary:- thyroid/parathyroid:0.17 adrenal gland:0.09 pancreas:- breast:0.48 salivary:-

Gene Information

IDs

Refseq ID NM_025213
Gene ID 57731
Unigene ID Hs.32706
Probe set ID -
Ensembl ID ENSG00000160460
GTEx ID ENSG00000160460

Orthologous Gene

Mouse[1]  NM_001199234, NM_001199235, NM_001199236, NM_032610
Rat[1]  NM_001199234, NM_001199235, NM_001199236, NM_032610

Chromosomal Region

19q13.2  [40,972,148  -  41,082,365]

Gene Family (Interpro ID)

IPR016146  Calponin-homology
IPR001715  Calponin-like actin-binding
IPR001849  Pleckstrin homology
IPR018159  Spectrin/alpha-actinin
IPR001605  Spectrin/pleckstrin-like

Link to Pubmed  (Pubmed ID)

8493579
10997877
11086001
11294830
11807096
12119179
12421765
12506198
12812986
14702039
16344560
17081983
19851296
20198315
20379614
21890473
21900206
23000965
24654937

Gene Ontology  (GO ID)

Biological Process

GO:0051693  actin filament capping
GO:0007628  adult walking behavior
GO:0007411  axon guidance
GO:0007409  axonogenesis
GO:0021952  central nervous system projection neuron axonogenesis
GO:0045162  clustering of voltage-gated sodium channels
GO:0007016  cytoskeletal anchoring at plasma membrane
GO:0090002  establishment of protein localization in plasma membrane
GO:0009566  fertilization
GO:0010459  negative regulation of heart rate
GO:0040018  positive regulation of multicellular organism growth
GO:0033135  regulation of peptidyl-serine phosphorylation
GO:0002028  regulation of sodium ion transport
GO:0007605  sensory perception of sound
GO:0019226  transmission of nerve impulse
GO:0016192  vesicle-mediated transport

Cellular Component

GO:0005912  adherens junction
GO:0043203  axon hillock
GO:0070852  cell body fiber
GO:0043025  cell soma
GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0043194  initial segment
GO:0016020  membrane
GO:0033268  node of Ranvier
GO:0016363  nuclear matrix
GO:0033270  paranode region of axon
GO:0005886  plasma membrane
GO:0016605  PML body
GO:0008091  spectrin

Molecular Function

GO:0003779  actin binding
GO:0030506  ankyrin binding
GO:0019902  phosphatase binding
GO:0005543  phospholipid binding
GO:0005515  protein binding
GO:0030507  spectrin binding
GO:0005200  structural constituent of cytoskeleton