protein tyrosine phosphatase, receptor type, J

 jump to detail

Synonym

R-PTP-ETA, DEP-1, R-PTP-eta, DEP1, CD148, protein tyrosine phosphatase, receptor type, J, Protein-tyrosine phosphatase receptor type J, CD148 antigen, SCC1, PTPRJ, HPTP eta, Protein-tyrosine phosphatase eta, HPTPeta, Density-enhanced phosphatase 1

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:17.80 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:30.70 spine:- retina:- eye:35.30 artery/aorta:- vein:- lymphnode:20.20 peripheral blood:72.90 spleen:170.20 thymus:- bone marrow:452.60 adipose:- bone:25.60 skin:52.80
GeneChip nodata
CAGE cerebrum:3.07 cerebellum:- brain stem:3.12 corpus callosum/glia:3.19 pineal gland:3.01 peripheral nerve:- spine:3.23 retina:- eye:- artery/aorta:2.86 vein:3.14 lymphnode:3.58 peripheral blood:- spleen:4.42 thymus:2.79 bone marrow:- adipose:2.64 bone:- skin:-
RNA-seq cerebrum:0.36 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.00 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.05 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:45.60 placenta:87.40 prostate:33.80 ovary:- testis:13 heart:12.80 muscle:20.10 esophagus:- stomach:63.70 intestine:64.80 colon:93.30     liver/hepato:84.40        lung:53.80    bladder:- kidney:31.20 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:26.70 breast:232.30 salivary:-
GeneChip nodata
CAGE uterus:2.23 placenta:3.88 prostate:2.89 ovary:2.09 testis:1.95 heart:2.56 muscle:1.81 esophagus:2.14 stomach:- intestine:3.53 colon:3.11     liver/hepato:3.25    lung:3.43 bladder:2.33 kidney:3.35 pituitary:3.56 thyroid/parathyroid:3.39 adrenal gland:- pancreas:2.86 breast:2.87 salivary:3.35
RNA-seq uterus:- placenta:- prostate:0.03 ovary:0.18 testis:0.58 heart:0.02 muscle:0.00 esophagus:- stomach:- intestine:- colon:0.03     liver/hepato:0.23        lung:0.44    bladder:- kidney:0.06 pituitary:- thyroid/parathyroid:0.59 adrenal gland:0.48 pancreas:- breast:0.17 salivary:-

Gene Information

IDs

Refseq ID NM_001098503
Gene ID 5795
Unigene ID Hs.318547
Probe set ID -
Ensembl ID ENSG00000149177
GTEx ID ENSG00000149177

Orthologous Gene

Mouse[6]  NM_001135657, NM_008982
Rat[6]  NM_001135657, NM_008982

Chromosomal Region

11p11.2  [48,002,110  -  48,192,393]

Gene Family (Interpro ID)

IPR003961  Fibronectin, type III
IPR008957  Fibronectin, type III-like fold
IPR000242  Protein-tyrosine phosphatase, receptor/non-receptor type

Link to Pubmed  (Pubmed ID)

7937872
7994032
9115287
9531590
9759839
9780142
10473595
10599888
10648410
10821867
10914487
11259588
12062403
12089527
12370829
12403354
12475979
12477932
12685844
12913111
14709717
15123617
15231692
15378013
15384144
16000320
16335952
16582570
16682945
16778204
18029348
18348712
18603590
18843023
18854154
18936167
19056867
19122201
19124506
19167335
19332538
19413345
19494114
19672627
19836242
19922411
20379614
20823296
20881960
21036128
21091576
21262971
21304107
21502573
21543337
21706016
21813734
21987572
22076464
22268729
22308318
22438257
22564856
22677127
22815804
23000965
23341091
23563607
23650535
24027763

Gene Ontology  (GO ID)

Biological Process

GO:0007596  blood coagulation
GO:0060242  contact inhibition
GO:0007507  heart development
GO:0030308  negative regulation of cell growth
GO:0030336  negative regulation of cell migration
GO:0008285  negative regulation of cell proliferation
GO:0042059  negative regulation of epidermal growth factor receptor signaling pathway
GO:0043407  negative regulation of MAP kinase activity
GO:0010642  negative regulation of platelet-derived growth factor receptor signaling pathway
GO:0051898  negative regulation of protein kinase B signaling cascade
GO:0050860  negative regulation of T cell receptor signaling pathway
GO:0043116  negative regulation of vascular permeability
GO:0048008  platelet-derived growth factor receptor signaling pathway
GO:0050918  positive chemotaxis
GO:0045785  positive regulation of cell adhesion
GO:0051894  positive regulation of focal adhesion formation
GO:0010759  positive regulation of macrophage chemotaxis
GO:0010572  positive regulation of platelet activation
GO:0051897  positive regulation of protein kinase B signaling cascade
GO:0030155  regulation of cell adhesion
GO:0001570  vasculogenesis

Cellular Component

GO:0009986  cell surface
GO:0005911  cell-cell junction
GO:0001772  immunological synapse
GO:0005887  integral to plasma membrane
GO:0005886  plasma membrane
GO:0032587  ruffle membrane

Molecular Function

GO:0008013  beta-catenin binding
GO:0070097  delta-catenin binding
GO:0045295  gamma-catenin binding
GO:0051019  mitogen-activated protein kinase binding
GO:0016791  phosphatase activity
GO:0005161  platelet-derived growth factor receptor binding
GO:0005515  protein binding
GO:0019901  protein kinase binding
GO:0004725  protein tyrosine phosphatase activity