protein tyrosine phosphatase, receptor type, K

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Synonym

protein tyrosine phosphatase, receptor type, K, Protein-tyrosine phosphatase kappa, PTPRK, DKFZp686C2268, R-PTP-kappa, DKFZp779N1045, PTPK

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:68.70 cerebellum:63 brain stem:- corpus callosum/glia:87.50 pineal gland:- peripheral nerve:61.30 spine:- retina:118.60 eye:29.40 artery/aorta:89.90 vein:- lymphnode:40.40 peripheral blood:- spleen:- thymus:12.90 bone marrow:- adipose:40.30 bone:25.60 skin:168
GeneChip cerebrum:7.88 cerebellum:6.52 brain stem:7.70 corpus callosum/glia:8.72 pineal gland:- peripheral nerve:5.92 spine:7.54 retina:- eye:- artery/aorta:7.42 vein:7.25 lymphnode:6.65 peripheral blood:- spleen:6.84 thymus:6.73 bone marrow:4.08 adipose:7.06 bone:- skin:7.25
CAGE cerebrum:4.39 cerebellum:- brain stem:4.68 corpus callosum/glia:5.06 pineal gland:2.32 peripheral nerve:- spine:4.28 retina:- eye:- artery/aorta:3.87 vein:3.85 lymphnode:3.44 peripheral blood:- spleen:3.51 thymus:4.30 bone marrow:- adipose:3.87 bone:- skin:-
RNA-seq cerebrum:3.40 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.73 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.21 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:72.90 placenta:69.20 prostate:67.60 ovary:111.80 testis:8.70 heart:76.60 muscle:20.10 esophagus:- stomach:85 intestine:64.80 colon:390.10     liver/hepato:158.30        lung:53.80    bladder:251.20 kidney:104 pituitary:116 thyroid/parathyroid:- adrenal gland:- pancreas:80 breast:213.70 salivary:-
GeneChip uterus:7.59 placenta:6.92 prostate:8.30 ovary:8.01 testis:4.82 heart:7.10 muscle:5.52 esophagus:6.73 stomach:8.21 intestine:7.79 colon:7.53 liver/hepato:7.97 lung:7.75 bladder:- kidney:7.08 pituitary:7.23 thyroid/parathyroid:7.10 adrenal gland:5.90 pancreas:7.73 breast:8.09 salivary:7.30
CAGE uterus:4.29 placenta:3.63 prostate:4.27 ovary:3.93 testis:2.82 heart:4.15 muscle:3.53 esophagus:3.93 stomach:- intestine:5.02 colon:4.66     liver/hepato:4.50    lung:4.66 bladder:4.28 kidney:4.21 pituitary:4.12 thyroid/parathyroid:3.48 adrenal gland:- pancreas:4.47 breast:4.32 salivary:3.98
RNA-seq uterus:- placenta:- prostate:3.93 ovary:3.71 testis:2.92 heart:2.92 muscle:1.77 esophagus:- stomach:- intestine:- colon:3.60     liver/hepato:3.18        lung:3.74    bladder:- kidney:3.55 pituitary:- thyroid/parathyroid:3.02 adrenal gland:3.02 pancreas:- breast:3.32 salivary:-

Gene Information

IDs

Refseq ID NM_002844
Gene ID 5796
Unigene ID Hs.155919
Probe set ID 203038_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000152894
GTEx ID ENSG00000152894

Orthologous Gene

Mouse[6]  NM_008983
Rat[2]  NM_001029902

Chromosomal Region

6q22.33  [128,289,924  -  128,841,870]

Gene Family (Interpro ID)

IPR003961  Fibronectin, type III
IPR008957  Fibronectin, type III-like fold
IPR000242  Protein-tyrosine phosphatase, receptor/non-receptor type

Link to Pubmed  (Pubmed ID)

7782276
8264577
8663237
8941358
9047348
9722959
11710941
12477932
12794170
14718574
15383276
15899872
16169070
16263724
16344560
16672235
16849327
17573772
17720884
18276111
19167335
19236842
19800317
19864455
19911372
20068591
20190752
20379614
21094132
21139048
21833088
21900206
21988832
23552869
23696788
24002526

Gene Ontology  (GO ID)

Biological Process

GO:0007155  cell adhesion
GO:0016477  cell migration
GO:0034614  cellular response to reactive oxygen species
GO:0034644  cellular response to UV
GO:0048041  focal adhesion formation
GO:0045786  negative regulation of cell cycle
GO:0030336  negative regulation of cell migration
GO:0008285  negative regulation of cell proliferation
GO:0010839  negative regulation of keratinocyte proliferation
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0006470  protein amino acid dephosphorylation
GO:0034394  protein localization at cell surface
GO:0007165  signal transduction
GO:0007179  transforming growth factor beta receptor signaling pathway

Cellular Component

GO:0005912  adherens junction
GO:0030424  axon
GO:0043025  cell soma
GO:0009986  cell surface
GO:0005911  cell-cell junction
GO:0030425  dendrite
GO:0016021  integral to membrane
GO:0005887  integral to plasma membrane
GO:0031256  leading edge membrane
GO:0001750  photoreceptor outer segment

Molecular Function

GO:0008013  beta-catenin binding
GO:0045295  gamma-catenin binding
GO:0005515  protein binding
GO:0019901  protein kinase binding
GO:0004725  protein tyrosine phosphatase activity
GO:0005001  transmembrane receptor protein tyrosine phosphatase activity