v-raf-1 murine leukemia viral oncogene homolog 1

Synonym

C-RAF, cRaf, Raf-1, RAF1, c-Raf, CRAF, RAF, RAF proto-oncogene serine/threonine-protein kinase, v-raf-1 murine leukemia viral oncogene homolog 1

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:115

cerebellum:201.50

brain stem:-

corpus callosum/glia:233.30

pineal gland:741.70

peripheral nerve:214.70

spine:224.60

retina:-

eye:129.30

artery/aorta:89.90

vein:66.60

lymphnode:121.30

peripheral blood:200.40

spleen:18.90

thymus:412.30

bone marrow:137.80

adipose:80.70

bone:115.20

skin:144

GeneChip

cerebrum:6.98

cerebellum:7.98

brain stem:6.87

corpus callosum/glia:7.50

pineal gland:-

peripheral nerve:7.48

spine:7.23

retina:-

eye:-

artery/aorta:8.04

vein:7.92

lymphnode:7.98

peripheral blood:-

spleen:8.14

thymus:8.32

bone marrow:8.29

adipose:7.72

bone:-

skin:8.17

CAGE

cerebrum:3.54

cerebellum:-

brain stem:3.44

corpus callosum/glia:3.82

pineal gland:3.75

peripheral nerve:-

spine:3.49

retina:-

eye:-

artery/aorta:3.96

vein:3.51

lymphnode:3.73

peripheral blood:-

spleen:3.74

thymus:3.88

bone marrow:-

adipose:3.78

bone:-

skin:-

RNA-seq

cerebrum:3.55

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:4.79

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:4.30

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:54.70

placenta:149.40

prostate:33.80

ovary:-

testis:116.80

heart:242.70

muscle:120.50

esophagus:-

stomach:85

intestine:64.80

colon:118.70

liver/hepato:84.40

lung:195.50

bladder:-

kidney:41.60

pituitary:116

thyroid/parathyroid:163.70

adrenal gland:50.80

pancreas:133.40

breast:74.30

salivary:-

GeneChip

uterus:8.03

placenta:7.88

prostate:8.10

ovary:8.20

testis:7.57

heart:8.26

muscle:8.97

esophagus:8.28

stomach:7.89

intestine:7.89

colon:7.58

liver/hepato:8.13

lung:8.04

bladder:-

kidney:7.94

pituitary:7.16

thyroid/parathyroid:8.23

adrenal gland:7.43

pancreas:6.96

breast:8.17

salivary:7.61

CAGE

uterus:3.95

placenta:3.86

prostate:3.71

ovary:3.82

testis:3.64

heart:3.98

muscle:4.39

esophagus:3.84

stomach:-

intestine:4.08

colon:3.84

liver/hepato:4.14

lung:3.61

bladder:3.76

kidney:3.78

pituitary:3.64

thyroid/parathyroid:3.96

adrenal gland:-

pancreas:4.09

breast:3.58

salivary:3.77

RNA-seq

uterus:-

placenta:-

prostate:5.09

ovary:4.90

testis:4.48

heart:5.32

muscle:5.94

esophagus:-

stomach:-

intestine:-

colon:4.21

liver/hepato:4.72

lung:4.68

bladder:-

kidney:4.71

pituitary:-

thyroid/parathyroid:5.78

adrenal gland:4.75

pancreas:-

breast:4.40

salivary:-

IDs

Refseq ID	NM_002880
Gene ID	5894
Unigene ID	Hs.159130
Probe set ID	201244_s_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000132155
GTEx ID	ENSG00000132155

Orthologous Gene

Mouse[2]	NM_029780
Rat [0]

Chromosomal Region

3p25.2 [12,625,100 - 12,705,725]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR000719	Protein kinase, catalytic domain
IPR011009	Protein kinase-like domain
IPR002290	Serine/threonine-protein kinase domain
IPR017442	Serine/threonine-protein kinase-like domain
IPR001245	Tyrosine-protein kinase, catalytic domain
IPR020635	Tyrosine-protein kinase, subgroup, catalytic domain

Gene Ontology (GO ID)

Biological Process

GO:0007190	activation of adenylate cyclase activity
GO:0000186	activation of MAPKK activity
GO:0006915	apoptosis
GO:0007411	axon guidance
GO:0007596	blood coagulation
GO:0008283	cell proliferation
GO:0007010	cytoskeleton organization
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0007507	heart development
GO:0045087	innate immune response
GO:0008286	insulin receptor signaling pathway
GO:0034220	ion transmembrane transport
GO:0000165	MAPKKK cascade
GO:0043066	negative regulation of apoptosis
GO:0043154	negative regulation of caspase activity
GO:0008285	negative regulation of cell proliferation
GO:0031333	negative regulation of protein complex assembly
GO:0048011	nerve growth factor receptor signaling pathway
GO:0030168	platelet activation
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0006468	protein amino acid phosphorylation
GO:0007265	Ras protein signal transduction
GO:0042981	regulation of apoptosis
GO:0045595	regulation of cell differentiation
GO:0035023	regulation of Rho protein signal transduction
GO:0001666	response to hypoxia
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0007268	synaptic transmission
GO:0055085	transmembrane transport
GO:0042060	wound healing

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005741	mitochondrial outer membrane
GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0031143	pseudopodium

Molecular Function

GO:0005524	ATP binding
GO:0042802	identical protein binding
GO:0004709	MAP kinase kinase kinase activity
GO:0046872	metal ion binding
GO:0031434	mitogen-activated protein kinase kinase binding
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0017016	Ras GTPase binding

v-raf-1 murine leukemia viral oncogene homolog 1

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function