RAP2B, member of RAS oncogene family

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Synonym

RAP2B, member of RAS oncogene family, Ras-related protein Rap-2b precursor, MGC20484, RAP2B

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:14.20 cerebellum:- brain stem:- corpus callosum/glia:29.20 pineal gland:- peripheral nerve:- spine:- retina:- eye:35.30 artery/aorta:30 vein:- lymphnode:10.10 peripheral blood:36.40 spleen:- thymus:- bone marrow:- adipose:- bone:- skin:33.60
GeneChip cerebrum:2.84 cerebellum:2.85 brain stem:2.82 corpus callosum/glia:2.86 pineal gland:- peripheral nerve:2.79 spine:2.77 retina:- eye:- artery/aorta:2.90 vein:3 lymphnode:2.87 peripheral blood:- spleen:2.77 thymus:2.80 bone marrow:2.97 adipose:2.81 bone:- skin:2.93
CAGE cerebrum:2.49 cerebellum:- brain stem:2.32 corpus callosum/glia:2.64 pineal gland:1.13 peripheral nerve:- spine:2.28 retina:- eye:- artery/aorta:2.83 vein:3.20 lymphnode:3.68 peripheral blood:- spleen:3.59 thymus:3.41 bone marrow:- adipose:3.42 bone:- skin:-
RNA-seq cerebrum:2.21 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.92 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.07 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:10.90 prostate:22.50 ovary:- testis:- heart:12.80 muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:48.90    bladder:- kidney:20.80 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:8.90 breast:9.30 salivary:-
GeneChip uterus:2.87 placenta:2.90 prostate:2.68 ovary:2.92 testis:2.73 heart:2.92 muscle:2.93 esophagus:2.91 stomach:2.78 intestine:2.90 colon:2.81 liver/hepato:2.86 lung:2.87 bladder:- kidney:2.81 pituitary:2.95 thyroid/parathyroid:2.72 adrenal gland:2.89 pancreas:3.01 breast:2.86 salivary:2.88
CAGE uterus:3.13 placenta:3.33 prostate:3.00 ovary:3.05 testis:2.59 heart:2.62 muscle:1.88 esophagus:3.71 stomach:- intestine:2.66 colon:2.81     liver/hepato:2.52    lung:3.60 bladder:2.96 kidney:2.59 pituitary:1.69 thyroid/parathyroid:2.44 adrenal gland:- pancreas:2.86 breast:3.19 salivary:2.12
RNA-seq uterus:- placenta:- prostate:2.28 ovary:3.15 testis:2.50 heart:1.24 muscle:0.57 esophagus:- stomach:- intestine:- colon:1.77     liver/hepato:1.63        lung:2.78    bladder:- kidney:2.12 pituitary:- thyroid/parathyroid:2.16 adrenal gland:3.18 pancreas:- breast:2.90 salivary:-

Gene Information

IDs

Refseq ID NM_002886
Gene ID 5912
Unigene ID Hs.98643
Probe set ID 214488_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000181467
GTEx ID ENSG00000181467

Orthologous Gene

Mouse[8]  NM_028712
Rat[1]  NM_133410

Chromosomal Region

3q25.2  [152,880,029  -  152,886,265]

Gene Family (Interpro ID)

IPR013753  Ras
IPR001806  Ras GTPase
IPR020849  Ras small GTPase
IPR003579  Ras small GTPase, Rab type
IPR005225  Small GTP-binding protein
IPR020851  Small GTPase
IPR003578  Small GTPase, Rho type

Link to Pubmed  (Pubmed ID)

2115998
2118648
3045729
8356055
8391995
8424780
10085114
10608883
10737800
10934204
11786539
11877431
12444546
12477932
15489334
15613030
16189514
16213650
16712791
17316888
17342744
18582561
19056867
19738201
19913121
20471030
20628086
21139048
21890473
21906983
21963094
21987572
22623428
23000965
23535297
24586238

Gene Ontology  (GO ID)

Biological Process

GO:0030336  negative regulation of cell migration
GO:0031954  positive regulation of protein amino acid autophosphorylation
GO:0032486  Rap protein signal transduction
GO:0007165  signal transduction

Cellular Component

GO:0005829  cytosol
GO:0055038  recycling endosome membrane

Molecular Function

GO:0005525  GTP binding
GO:0003924  GTPase activity
GO:0019904  protein domain specific binding