roundabout, axon guidance receptor, homolog 1 (Drosophila)

Synonym

H-Robo-1, ROBO1, Deleted in U twenty twenty, FLJ21882, MGC131599, SAX3, DUTT1, Roundabout homolog 1 precursor, MGC133277

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:86.50

cerebellum:63

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:61.30

spine:-

retina:118.60

eye:23.50

artery/aorta:30

vein:-

lymphnode:-

peripheral blood:-

spleen:37.80

thymus:51.50

bone marrow:19.70

adipose:121

bone:38.40

skin:144

GeneChip

nodata

CAGE

cerebrum:3.34

cerebellum:-

brain stem:3.34

corpus callosum/glia:3.58

pineal gland:1.34

peripheral nerve:-

spine:3.08

retina:-

eye:-

artery/aorta:2.95

vein:2.85

lymphnode:3.11

peripheral blood:-

spleen:3.01

thymus:3.30

bone marrow:-

adipose:2.92

bone:-

skin:-

RNA-seq

cerebrum:0.65

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:0.56

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:0.67

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:-

placenta:14.60

prostate:112.60

ovary:74.50

testis:69.20

heart:38.30

muscle:20.10

esophagus:-

stomach:106.20

intestine:32.40

colon:33.90

liver/hepato:52.80

lung:24.40

bladder:-

kidney:-

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:17.80

breast:65.10

salivary:-

GeneChip

nodata

CAGE

uterus:3.26

placenta:1.95

prostate:3.13

ovary:3.18

testis:2.93

heart:2.80

muscle:1.64

esophagus:3.00

stomach:-

intestine:2.09

colon:2.50

liver/hepato:1.90

lung:2.80

bladder:2.76

kidney:1.67

pituitary:3.87

thyroid/parathyroid:2.23

adrenal gland:-

pancreas:0.58

breast:2.91

salivary:2.46

RNA-seq

uterus:-

placenta:-

prostate:0.92

ovary:1.04

testis:1.27

heart:0.24

muscle:0.29

esophagus:-

stomach:-

intestine:-

colon:1.51

liver/hepato:0.02

lung:0.73

bladder:-

kidney:0.47

pituitary:-

thyroid/parathyroid:0.60

adrenal gland:0.76

pancreas:-

breast:1.10

salivary:-

IDs

Refseq ID	NM_001145845
Gene ID	6091
Unigene ID	Hs.13640
Probe set ID	-
Ensembl ID	ENSG00000169855
GTEx ID	ENSG00000169855

Orthologous Gene

Mouse[1]	NM_019413
Rat[1]	NM_022188

Chromosomal Region

3p12.2 [78,646,390 - 79,816,965]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR003961	Fibronectin, type III
IPR008957	Fibronectin, type III-like fold
IPR013106	Immunoglobulin V-set
IPR003596	Immunoglobulin V-set, subgroup

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

GO:0006919	activation of caspase activity
GO:0007411	axon guidance
GO:0016199	axon midline choice point recognition
GO:0007155	cell adhesion
GO:0002042	cell migration involved in sprouting angiogenesis
GO:0021836	chemorepulsion involved in postnatal olfactory bulb interneuron migration
GO:0007156	homophilic cell adhesion
GO:0060763	mammary duct terminal end bud growth
GO:0070100	negative regulation of chemokine-mediated signaling pathway
GO:0033600	negative regulation of mammary gland epithelial cell proliferation
GO:0050925	negative regulation of negative chemotaxis
GO:0007399	nervous system development
GO:0050772	positive regulation of axonogenesis

Cellular Component

GO:0030673	axolemma
GO:0009986	cell surface
GO:0005737	cytoplasm
GO:0005887	integral to plasma membrane
GO:0005886	plasma membrane

Molecular Function

GO:0008046	axon guidance receptor activity
GO:0042802	identical protein binding
GO:0030275	LRR domain binding
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity

roundabout, axon guidance receptor, homolog 1 (Drosophila)

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function