ribosomal protein S6 kinase, 90kDa, polypeptide 3

Synonym

pp90RSK2, S6K-alpha 3, p90-RSK 3, MAPKAPK1B, 90 kDa ribosomal protein S6 kinase 3, ribosomal protein S6 kinase, 90kDa, polypeptide 3, RSK-2, MAP kinase-activated protein kinase 1b, RPS6KA3, RSK2, Insulin-stimulated protein kinase 1, S6K-alpha3, p90-RSK2, Ribosomal protein S6 kinase alpha-3, ISPK1, ISPK-1, MRX19, Ribosomal S6 kinase 2, HU-3

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:5.90

cerebellum:12.60

brain stem:-

corpus callosum/glia:29.20

pineal gland:-

peripheral nerve:61.30

spine:-

retina:355.90

eye:29.40

artery/aorta:149.90

vein:-

lymphnode:70.80

peripheral blood:-

spleen:56.70

thymus:25.80

bone marrow:39.40

adipose:-

bone:51.20

skin:72

GeneChip

cerebrum:4.94

cerebellum:4.89

brain stem:4.89

corpus callosum/glia:4.58

pineal gland:-

peripheral nerve:5.57

spine:4.94

retina:-

eye:-

artery/aorta:5.30

vein:5.60

lymphnode:5.82

peripheral blood:-

spleen:6.10

thymus:6.66

bone marrow:5.65

adipose:5.56

bone:-

skin:5.67

CAGE

cerebrum:3.17

cerebellum:-

brain stem:3.06

corpus callosum/glia:2.62

pineal gland:3.66

peripheral nerve:-

spine:3.50

retina:-

eye:-

artery/aorta:3.76

vein:3.98

lymphnode:4.06

peripheral blood:-

spleen:4.15

thymus:4.12

bone marrow:-

adipose:3.93

bone:-

skin:-

RNA-seq

cerebrum:2.66

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:4.01

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:3.53

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:45.60

placenta:25.50

prostate:78.90

ovary:74.50

testis:8.70

heart:25.50

muscle:160.70

esophagus:-

stomach:85

intestine:-

colon:42.40

liver/hepato:42.20

lung:83.10

bladder:-

kidney:72.80

pituitary:-

thyroid/parathyroid:491.20

adrenal gland:50.80

pancreas:26.70

breast:74.30

salivary:-

GeneChip

uterus:5.40

placenta:5.20

prostate:6.09

ovary:5.36

testis:4.45

heart:5.62

muscle:6.97

esophagus:5.74

stomach:5.30

intestine:6.11

colon:5.61

liver/hepato:5.50

lung:5.79

bladder:-

kidney:4.82

pituitary:5.09

thyroid/parathyroid:5.30

adrenal gland:5.38

pancreas:5.59

breast:5.33

salivary:4.88

CAGE

uterus:3.52

placenta:3.24

prostate:3.68

ovary:3.49

testis:2.65

heart:3.86

muscle:3.86

esophagus:3.56

stomach:-

intestine:4.05

colon:4.08

liver/hepato:3.53

lung:4.17

bladder:3.94

kidney:3.53

pituitary:3.21

thyroid/parathyroid:3.47

adrenal gland:-

pancreas:3.13

breast:3.83

salivary:3.24

RNA-seq

uterus:-

placenta:-

prostate:3.56

ovary:3.42

testis:3.07

heart:3.01

muscle:3.91

esophagus:-

stomach:-

intestine:-

colon:3.80

liver/hepato:3.63

lung:4.01

bladder:-

kidney:3.32

pituitary:-

thyroid/parathyroid:3.71

adrenal gland:3.74

pancreas:-

breast:3.21

salivary:-

IDs

Refseq ID	NM_004586
Gene ID	6197
Unigene ID	Hs.445387
Probe set ID	203843_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000177189
GTEx ID	ENSG00000177189

Orthologous Gene

Mouse[3]	NM_148945
Rat [0]

Chromosomal Region

Xp22.12 [20,168,029 - 20,285,523]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR000961	AGC-kinase, C-terminal
IPR000719	Protein kinase, catalytic domain
IPR011009	Protein kinase-like domain
IPR002290	Serine/threonine-protein kinase domain
IPR017442	Serine/threonine-protein kinase-like domain
IPR001245	Tyrosine-protein kinase, catalytic domain
IPR020635	Tyrosine-protein kinase, subgroup, catalytic domain

Gene Ontology (GO ID)

Biological Process

GO:0007411	axon guidance
GO:0007049	cell cycle
GO:0007417	central nervous system development
GO:0045087	innate immune response
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0002756	MyD88-independent toll-like receptor signaling pathway
GO:0043066	negative regulation of apoptosis
GO:0043154	negative regulation of caspase activity
GO:0048011	nerve growth factor receptor signaling pathway
GO:0045597	positive regulation of cell differentiation
GO:0030307	positive regulation of cell growth
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0043620	regulation of transcription in response to stress
GO:0043555	regulation of translation in response to stress
GO:0032496	response to lipopolysaccharide
GO:0007165	signal transduction
GO:0001501	skeletal system development
GO:0051403	stress-activated MAPK cascade
GO:0007268	synaptic transmission
GO:0034166	toll-like receptor 10 signaling pathway
GO:0034134	toll-like receptor 2 signaling pathway
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0034146	toll-like receptor 5 signaling pathway
GO:0034162	toll-like receptor 9 signaling pathway
GO:0002224	toll-like receptor signaling pathway

Cellular Component

GO:0005829	cytosol
GO:0005654	nucleoplasm

Molecular Function

GO:0005524	ATP binding
GO:0043027	caspase inhibitor activity
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0019901	protein kinase binding
GO:0004674	protein serine/threonine kinase activity

ribosomal protein S6 kinase, 90kDa, polypeptide 3

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function