ribosomal protein S6 kinase, 70kDa, polypeptide 2

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Synonym

p70S6Kb, 70 kDa ribosomal protein S6 kinase 2, p70-beta, p70 S6 kinase beta, P70-beta-2, S6K-beta2, S6 kinase-related kinase, p70(S6K)-beta, P70-beta-1, KLS, Serine/threonine-protein kinase 14 beta, p70-S6KB, S6K2, S6K-beta, p70 ribosomal S6 kinase beta, P70-BETA, Ribosomal protein S6 kinase beta-2, SRK, RPS6KB2, ribosomal protein S6 kinase, 70kDa, polypeptide 2, p70 S6Kbeta, STK14B, P70-beta

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:23.70 cerebellum:25.20 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:70.50 artery/aorta:- vein:- lymphnode:50.60 peripheral blood:127.50 spleen:- thymus:25.80 bone marrow:19.70 adipose:- bone:- skin:24
GeneChip cerebrum:6.71 cerebellum:7.05 brain stem:6.60 corpus callosum/glia:6.85 pineal gland:- peripheral nerve:6.59 spine:6.52 retina:- eye:- artery/aorta:6.95 vein:6.89 lymphnode:7.15 peripheral blood:- spleen:6.88 thymus:6.93 bone marrow:6.87 adipose:6.89 bone:- skin:7.59
CAGE cerebrum:2.77 cerebellum:- brain stem:2.65 corpus callosum/glia:2.93 pineal gland:2.78 peripheral nerve:- spine:2.58 retina:- eye:- artery/aorta:3.02 vein:2.96 lymphnode:3.08 peripheral blood:- spleen:3.10 thymus:3.25 bone marrow:- adipose:2.65 bone:- skin:-
RNA-seq cerebrum:1.86 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:4.10 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.72 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:18.20 placenta:76.50 prostate:33.80 ovary:74.50 testis:21.60 heart:25.50 muscle:60.30 esophagus:- stomach:21.20 intestine:32.40 colon:25.40     liver/hepato:42.20        lung:34.20    bladder:- kidney:10.40 pituitary:- thyroid/parathyroid:- adrenal gland:101.60 pancreas:53.30 breast:9.30 salivary:-
GeneChip uterus:6.71 placenta:6.98 prostate:6.70 ovary:6.75 testis:6.45 heart:6.98 muscle:6.97 esophagus:7.73 stomach:6.81 intestine:6.81 colon:7.03 liver/hepato:6.92 lung:6.99 bladder:- kidney:6.76 pituitary:6.87 thyroid/parathyroid:7.03 adrenal gland:6.98 pancreas:7.05 breast:7.01 salivary:6.99
CAGE uterus:2.84 placenta:2.89 prostate:2.72 ovary:2.63 testis:2.64 heart:2.54 muscle:3.13 esophagus:3.17 stomach:- intestine:3.22 colon:3.06     liver/hepato:3.51    lung:2.52 bladder:2.68 kidney:2.66 pituitary:3.00 thyroid/parathyroid:2.59 adrenal gland:- pancreas:3.16 breast:2.87 salivary:2.78
RNA-seq uterus:- placenta:- prostate:3.30 ovary:3.12 testis:2.71 heart:2.25 muscle:2.89 esophagus:- stomach:- intestine:- colon:2.22     liver/hepato:3.81        lung:3.06    bladder:- kidney:3.13 pituitary:- thyroid/parathyroid:3.54 adrenal gland:3.52 pancreas:- breast:2.94 salivary:-

Gene Information

IDs

Refseq ID NM_003952
Gene ID 6199
Unigene ID Hs.534345
Probe set ID 203777_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000175634
GTEx ID ENSG00000175634

Orthologous Gene

Mouse[1]  NM_021485
Rat[1]  NM_001010962

Chromosomal Region

11q13.2  [67,195,931  -  67,202,872]

Gene Family (Interpro ID)

IPR000961  AGC-kinase, C-terminal
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

9804755
9878560
10490847
10490848
11108711
11108720
11500364
11733037
11753643
12087098
12176053
12477932
12529391
12569102
12713446
12818373
12875979
14729629
15051500
15071500
15489334
15589845
16640565
16763566
16810323
17081983
17786541
19953087
19961954
20098747
20308064
20819778
20932932
20953835
21035469
21427355
21444676
21900206
21988832
22939629
22955948
23393338
23602568
23940030
24447338

Gene Ontology  (GO ID)

Biological Process

GO:0007173  epidermal growth factor receptor signaling pathway
GO:0008543  fibroblast growth factor receptor signaling pathway
GO:0045087  innate immune response
GO:0048011  nerve growth factor receptor signaling pathway
GO:0048015  phosphoinositide-mediated signaling
GO:0045948  positive regulation of translational initiation
GO:0043491  protein kinase B signaling cascade
GO:0007165  signal transduction
GO:0006412  translation

Cellular Component

GO:0005737  cytoplasm
GO:0005654  nucleoplasm

Molecular Function

GO:0005524  ATP binding
GO:0042277  peptide binding
GO:0004672  protein kinase activity
GO:0004674  protein serine/threonine kinase activity
GO:0004711  ribosomal protein S6 kinase activity