ryanodine receptor 1 (skeletal)

Synonym

central core disease of muscle, CCO, Skeletal muscle-type ryanodine receptor, SKRR, RyR1, ryanodine receptor 1 (skeletal), RYR, MHS1, MHS, Ryanodine receptor 1, RYDR, RYR1, RYR-1, Skeletal muscle calcium release channel

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:28.40

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:148.30

peripheral nerve:30.70

spine:-

retina:-

eye:11.80

artery/aorta:-

vein:-

lymphnode:10.10

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:-

bone:12.80

skin:67.20

GeneChip

cerebrum:5.23

cerebellum:5.58

brain stem:5.22

corpus callosum/glia:5.32

pineal gland:-

peripheral nerve:5.38

spine:4.90

retina:-

eye:-

artery/aorta:4.21

vein:4.08

lymphnode:4.36

peripheral blood:-

spleen:4.01

thymus:4.22

bone marrow:4.07

adipose:4.16

bone:-

skin:5.42

CAGE

cerebrum:2.19

cerebellum:-

brain stem:2.50

corpus callosum/glia:2.92

pineal gland:5.03

peripheral nerve:-

spine:2.37

retina:-

eye:-

artery/aorta:1.16

vein:2.64

lymphnode:2.06

peripheral blood:-

spleen:0.32

thymus:0.33

bone marrow:-

adipose:3.54

bone:-

skin:-

RNA-seq

cerebrum:0.00

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:0.00

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:0.00

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:-

placenta:3.60

prostate:-

ovary:-

testis:21.60

heart:-

muscle:502.30

esophagus:-

stomach:-

intestine:-

colon:8.50

liver/hepato:-

lung:4.90

bladder:-

kidney:-

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:-

salivary:-

GeneChip

uterus:4.01

placenta:3.95

prostate:4.02

ovary:3.98

testis:5.81

heart:3.95

muscle:10.40

esophagus:7.18

stomach:3.73

intestine:4.92

colon:4.03

liver/hepato:3.79

lung:4.34

bladder:-

kidney:4.13

pituitary:4.10

thyroid/parathyroid:4.03

adrenal gland:3.96

pancreas:4.41

breast:4.57

salivary:4.10

CAGE

uterus:0.96

placenta:0.99

prostate:1.32

ovary:0.20

testis:1.18

heart:0.69

muscle:6.77

esophagus:2.70

stomach:-

intestine:0.69

colon:1.11

liver/hepato:0.26

lung:0.21

bladder:0.64

kidney:0.21

pituitary:0.19

thyroid/parathyroid:2.40

adrenal gland:-

pancreas:0

breast:1.36

salivary:1.15

RNA-seq

uterus:-

placenta:-

prostate:0.00

ovary:0.00

testis:0.49

heart:0.00

muscle:5.90

esophagus:-

stomach:-

intestine:-

colon:0.03

liver/hepato:0.00

lung:0.00

bladder:-

kidney:0.00

pituitary:-

thyroid/parathyroid:1.68

adrenal gland:0.13

pancreas:-

breast:0.92

salivary:-

IDs

Refseq ID	NM_000540
Gene ID	6261
Unigene ID	Hs.466664
Probe set ID	205485_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000196218
GTEx ID	ENSG00000196218

Orthologous Gene

Mouse[1]	NM_009109
Rat[1]	NM_009109

Chromosomal Region

19q13.2 [38,924,340 - 39,078,204]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR001870	B302 (SPRY)-like
IPR003877	SPla/RYanodine receptor SPRY
IPR018355	SPla/RYanodine receptor subgroup

Gene Ontology (GO ID)

Biological Process

GO:0006816	calcium ion transport
GO:0071313	cellular response to caffeine
GO:0051480	cytosolic calcium ion homeostasis
GO:0034220	ion transmembrane transport
GO:0006936	muscle contraction
GO:0043931	ossification involved in bone maturation
GO:0003151	outflow tract morphogenesis
GO:0051209	release of sequestered calcium ion into cytosol
GO:0014808	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0031000	response to caffeine
GO:0001666	response to hypoxia
GO:0048741	skeletal muscle fiber development
GO:0043588	skin development
GO:0055085	transmembrane transport

Cellular Component

GO:0005938	cell cortex
GO:0005737	cytoplasm
GO:0031674	I band
GO:0005887	integral to plasma membrane
GO:0030314	junctional membrane complex
GO:0014701	junctional sarcoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0016529	sarcoplasmic reticulum
GO:0033017	sarcoplasmic reticulum membrane
GO:0005790	smooth endoplasmic reticulum
GO:0030315	T-tubule
GO:0014802	terminal cisterna

Molecular Function

GO:0005262	calcium channel activity
GO:0005509	calcium ion binding
GO:0015278	calcium-release channel activity
GO:0005516	calmodulin binding
GO:0002020	protease binding
GO:0005515	protein binding
GO:0005219	ryanodine-sensitive calcium-release channel activity
GO:0005245	voltage-gated calcium channel activity

ryanodine receptor 1 (skeletal)

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function