ryanodine receptor 2 (cardiac)

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Synonym

RYR2, RYR-2, Cardiac muscle-type ryanodine receptor, hRYR-2, RyR2, VTSIP, Ryanodine receptor 2, ARVC2, ryanodine receptor 2 (cardiac)

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:79.40 cerebellum:75.60 brain stem:- corpus callosum/glia:29.20 pineal gland:296.70 peripheral nerve:61.30 spine:- retina:- eye:52.90 artery/aorta:- vein:- lymphnode:10.10 peripheral blood:- spleen:18.90 thymus:- bone marrow:39.40 adipose:- bone:12.80 skin:24
GeneChip nodata
CAGE cerebrum:4.25 cerebellum:- brain stem:1.81 corpus callosum/glia:1.38 pineal gland:4.77 peripheral nerve:- spine:1.83 retina:- eye:- artery/aorta:4.70 vein:2.60 lymphnode:0.23 peripheral blood:- spleen:1.18 thymus:0.18 bone marrow:- adipose:1.21 bone:- skin:-
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:7.30 prostate:56.30 ovary:37.30 testis:34.60 heart:306.50 muscle:20.10 esophagus:- stomach:106.20 intestine:- colon:42.40     liver/hepato:158.30        lung:34.20    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:71.10 breast:9.30 salivary:-
GeneChip nodata
CAGE uterus:2.07 placenta:0.88 prostate:2.62 ovary:2.18 testis:1.53 heart:6.68 muscle:0.75 esophagus:3.04 stomach:- intestine:1.15 colon:2.21     liver/hepato:0.26    lung:2.99 bladder:2.54 kidney:0.39 pituitary:3.08 thyroid/parathyroid:2.31 adrenal gland:- pancreas:0.58 breast:0 salivary:0
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_001035000
Gene ID 6262
Unigene ID Hs.109514
Probe set ID -
Ensembl ID -
GTEx ID -

Orthologous Gene

Mouse [0]  
Rat [0]  

Chromosomal Region

1q43  [237,205,505  -  238,129,359]

Gene Family (Interpro ID)

IPR001870  B302 (SPRY)-like
IPR018249  EF-HAND 2
IPR003877  SPla/RYanodine receptor SPRY
IPR018355  SPla/RYanodine receptor subgroup

Link to Pubmed  (Pubmed ID)

2380170
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8406504
8589694
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24837260

Gene Ontology  (GO ID)

Biological Process

GO:0030509  BMP signaling pathway
GO:0006816  calcium ion transport
GO:0060402  calcium ion transport into cytosol
GO:0019722  calcium-mediated signaling
GO:0060048  cardiac muscle contraction
GO:0003300  cardiac muscle hypertrophy
GO:0006874  cellular calcium ion homeostasis
GO:0071313  cellular response to caffeine
GO:0051480  cytosolic calcium ion homeostasis
GO:0005513  detection of calcium ion
GO:0003143  embryonic heart tube morphogenesis
GO:0034220  ion transmembrane transport
GO:0003220  left ventricular cardiac muscle tissue morphogenesis
GO:0010460  positive regulation of heart rate
GO:0051284  positive regulation of sequestering of calcium ion
GO:0055117  regulation of cardiac muscle contraction
GO:0010881  regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0002027  regulation of heart rate
GO:0051209  release of sequestered calcium ion into cytosol
GO:0014808  release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0031000  response to caffeine
GO:0001666  response to hypoxia
GO:0051775  response to redox state
GO:0070296  sarcoplasmic reticulum calcium ion transport
GO:0055085  transmembrane transport
GO:0060070  Wnt receptor signaling pathway through beta-catenin

Cellular Component

GO:0034704  calcium channel complex
GO:0014701  junctional sarcoplasmic reticulum membrane
GO:0016020  membrane
GO:0005886  plasma membrane
GO:0043234  protein complex
GO:0016529  sarcoplasmic reticulum
GO:0033017  sarcoplasmic reticulum membrane
GO:0030018  Z disc

Molecular Function

GO:0005262  calcium channel activity
GO:0005509  calcium ion binding
GO:0048763  calcium-induced calcium release activity
GO:0015278  calcium-release channel activity
GO:0005516  calmodulin binding
GO:0019899  enzyme binding
GO:0042802  identical protein binding
GO:0005218  intracellular ligand-gated calcium channel activity
GO:0005515  protein binding
GO:0034236  protein kinase A catalytic subunit binding
GO:0034237  protein kinase A regulatory subunit binding
GO:0043621  protein self-association
GO:0005219  ryanodine-sensitive calcium-release channel activity
GO:0043924  suramin binding