sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like

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Synonym

Lathosterol 5-desaturase, ERG3, Delta-7-sterol 5-desaturase, SC5DL, SC5D, Sterol-C5-desaturase, Lathosterol oxidase, C-5 sterol desaturase

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:179 cerebellum:12.60 brain stem:- corpus callosum/glia:145.80 pineal gland:- peripheral nerve:214.70 spine:224.60 retina:- eye:58.80 artery/aorta:239.80 vein:133.30 lymphnode:70.80 peripheral blood:36.40 spleen:37.80 thymus:38.70 bone marrow:- adipose:- bone:64 skin:91.20
GeneChip cerebrum:8.37 cerebellum:7.46 brain stem:9.22 corpus callosum/glia:8.35 pineal gland:- peripheral nerve:8.51 spine:9.12 retina:- eye:- artery/aorta:6.69 vein:6.42 lymphnode:6.72 peripheral blood:- spleen:6.06 thymus:6.40 bone marrow:5.69 adipose:7.60 bone:- skin:7.50
CAGE cerebrum:4.67 cerebellum:- brain stem:5.03 corpus callosum/glia:4.75 pineal gland:4.94 peripheral nerve:- spine:5.26 retina:- eye:- artery/aorta:3.66 vein:3.47 lymphnode:3.48 peripheral blood:- spleen:3.23 thymus:3.19 bone marrow:- adipose:3.90 bone:- skin:-
RNA-seq cerebrum:4.24 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.70 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.09 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:27.30 placenta:32.80 prostate:191.50 ovary:111.80 testis:56.20 heart:51.10 muscle:- esophagus:- stomach:- intestine:32.40 colon:17     liver/hepato:63.30        lung:29.30    bladder:376.80 kidney:104 pituitary:- thyroid/parathyroid:- adrenal gland:253.90 pancreas:62.20 breast:130.10 salivary:328.40
GeneChip uterus:7.01 placenta:5.51 prostate:10.36 ovary:7.04 testis:7.38 heart:6.96 muscle:5.98 esophagus:7.77 stomach:6.76 intestine:7.03 colon:6 liver/hepato:9.85 lung:7.02 bladder:- kidney:7.38 pituitary:7.61 thyroid/parathyroid:7 adrenal gland:8.02 pancreas:6.70 breast:7.79 salivary:7.21
CAGE uterus:3.92 placenta:2.88 prostate:4.57 ovary:3.89 testis:3.96 heart:3.48 muscle:2.41 esophagus:4.68 stomach:- intestine:4.44 colon:3.58     liver/hepato:5.52    lung:4.08 bladder:4.50 kidney:4.47 pituitary:4.55 thyroid/parathyroid:3.70 adrenal gland:- pancreas:3.42 breast:3.96 salivary:3.87
RNA-seq uterus:- placenta:- prostate:3.94 ovary:3.42 testis:3.16 heart:2.47 muscle:1.56 esophagus:- stomach:- intestine:- colon:2.55     liver/hepato:5.31        lung:3.17    bladder:- kidney:3.54 pituitary:- thyroid/parathyroid:2.48 adrenal gland:2.43 pancreas:- breast:2.82 salivary:-

Gene Information

IDs

Refseq ID NM_006918
Gene ID 6309
Unigene ID Hs.287749
Probe set ID 211423_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000109929
GTEx ID ENSG00000109929

Orthologous Gene

Mouse[6]  NM_172769
Rat [0]  

Chromosomal Region

11q23.3  [121,163,162  -  121,179,403]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

7560069
7770068
7961720
8125298
8466936
8976377
10344195
10601301
10769175
10786622
11731337
12189593
12477932
12812989
14702039
15489334
17207965
18660489
20144677
20379614
20634891
21890473
21906983
21963094
21987572
23000965

Gene Ontology  (GO ID)

Biological Process

GO:0006695  cholesterol biosynthetic process
GO:0033490  cholesterol biosynthetic process via lathosterol
GO:0006633  fatty acid biosynthetic process
GO:0006629  lipid metabolic process

Cellular Component

GO:0005789  endoplasmic reticulum membrane
GO:0016021  integral to membrane

Molecular Function

GO:0000248  C-5 sterol desaturase activity
GO:0005506  iron ion binding
GO:0050046  lathosterol oxidase activity