bone gamma-carboxyglutamate (gla) protein

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Synonym

PMF1, Bone Gla-protein, Osteocalcin precursor, Gamma-carboxyglutamic acid-containing protein, BGLAP, BGP

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:4.91 cerebellum:4.98 brain stem:5.03 corpus callosum/glia:4.70 pineal gland:- peripheral nerve:4.51 spine:4.93 retina:- eye:- artery/aorta:5.15 vein:4.80 lymphnode:5.01 peripheral blood:- spleen:4.97 thymus:4.81 bone marrow:5.71 adipose:4.80 bone:- skin:4.95
CAGE cerebrum:1.43 cerebellum:- brain stem:1.47 corpus callosum/glia:1.59 pineal gland:0 peripheral nerve:- spine:1.91 retina:- eye:- artery/aorta:2.32 vein:0.18 lymphnode:0.12 peripheral blood:- spleen:0 thymus:0.33 bone marrow:- adipose:0 bone:- skin:-
RNA-seq cerebrum:0.82 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.19 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:5.03 placenta:4.79 prostate:5.22 ovary:5.15 testis:4.72 heart:4.92 muscle:4.83 esophagus:4.86 stomach:4.77 intestine:4.84 colon:4.69 liver/hepato:4.99 lung:4.84 bladder:- kidney:4.80 pituitary:5.07 thyroid/parathyroid:5.30 adrenal gland:4.99 pancreas:4.94 breast:4.83 salivary:4.88
CAGE uterus:0 placenta:1.05 prostate:0 ovary:0 testis:0 heart:0 muscle:0.13 esophagus:0.33 stomach:- intestine:1.56 colon:1.57     liver/hepato:0    lung:0.10 bladder:0.09 kidney:0 pituitary:0.10 thyroid/parathyroid:0 adrenal gland:- pancreas:0 breast:0 salivary:0.83
RNA-seq uterus:- placenta:- prostate:0.33 ovary:0.73 testis:0.32 heart:0.05 muscle:0.00 esophagus:- stomach:- intestine:- colon:1.27     liver/hepato:0.58        lung:0.98    bladder:- kidney:0.00 pituitary:- thyroid/parathyroid:0.00 adrenal gland:0.24 pancreas:- breast:0.47 salivary:-

Gene Information

IDs

Refseq ID NM_199173
Gene ID 632
Unigene ID -
Probe set ID 206956_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000242252
GTEx ID ENSG00000242252

Orthologous Gene

Mouse[4]  NM_001037939, NM_007541, NM_001032298, NM_031368
Rat [0]  

Chromosomal Region

1q22  [156,211,753  -  156,213,112]

Gene Family (Interpro ID)

IPR000294  Gamma-carboxyglutamic acid-rich (GLA) domain

Link to Pubmed  (Pubmed ID)

2336375
2394711
2785029
3019668
6967872
7768973
9076588
10393081
10419538
10486212
10865224
11199188
11396736
11574953
11856645
11918225
11979972
12112004
12145306
12202187
12270142
12393937
12467198
12477932
12565780
12674332
12843190
12879219
15108065
15108070
15502821
15562030
15753298
15949438
16263577
16387359
16412323
16735944
17000892
17023519
17242729
17252541
17254772
17627084
17889845
18160010
18163903
18171674
18285546
18321663
18496130
18551993
18657532
19031822
19063687
19088165
19136823
19453261
19595020
19641839
19732762
19751416
19751417
19767102
19856264
19877133
20139978
20157712
20200947
20221651
20305683
20355242
20395593
20410230
20433876
20501596
20562864
20574675
20577791
20587710
20592451
20625700
20694489
20831864
21153019
21169728
21178793
21292339
21301010
21333348
21353261
21425331
21427224
21487672
21521304
21521333
21558934
21590731
21713451
21935388
21944272
21964930
21968268
22034088
22068385
22068892
22102412
22136751
22219025
22294259
22517558
22577088
22615158
22652825
22679141
22735266
22752126
22773701
22842327
22978420
23001602
23135318
23137636
23162093
23206207
23261860
23342952
23386651
23485732
23512417
23553865
23616149
23696116
23788330
24037881
24078129
24113735
24167545
24219294
24455828
24503413

Gene Ontology  (GO ID)

Biological Process

GO:0060348  bone development
GO:0030282  bone mineralization
GO:0007155  cell adhesion
GO:0007569  cell aging
GO:0071363  cellular response to growth factor stimulus
GO:0071305  cellular response to vitamin D
GO:0042476  odontogenesis
GO:0002076  osteoblast development
GO:0001649  osteoblast differentiation
GO:0030500  regulation of bone mineralization
GO:0045124  regulation of bone resorption
GO:0045670  regulation of osteoclast differentiation
GO:0014823  response to activity
GO:0042493  response to drug
GO:0043627  response to estrogen stimulus
GO:0045471  response to ethanol
GO:0051384  response to glucocorticoid stimulus
GO:0009629  response to gravity
GO:0033594  response to hydroxyisoflavone
GO:0009612  response to mechanical stimulus
GO:0033574  response to testosterone stimulus
GO:0033280  response to vitamin D
GO:0032571  response to vitamin K
GO:0010043  response to zinc ion
GO:0001501  skeletal system development

Cellular Component

GO:0030425  dendrite
GO:0005576  extracellular region
GO:0005615  extracellular space
GO:0005794  Golgi apparatus
GO:0031988  membrane-bounded vesicle
GO:0043204  perikaryon
GO:0005791  rough endoplasmic reticulum

Molecular Function

GO:0005509  calcium ion binding
GO:0046848  hydroxyapatite binding
GO:0008147  structural constituent of bone
GO:0005198  structural molecule activity