chemokine (C-C motif) ligand 5

Synonym

T cell-specific protein P228, TCP228, Small inducible cytokine A5 precursor, D17S136E, chemokine (C-C motif) ligand 5, SISd, SIS-delta, small inducible cytokine A5 (RANTES), MGC17164, T-cell-specific RANTES protein, SCYA5, CCL5, RANTES

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:-

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:30.30

peripheral blood:72.90

spleen:18.90

thymus:-

bone marrow:98.40

adipose:40.30

bone:25.60

skin:57.60

GeneChip

cerebrum:4.50

cerebellum:4.68

brain stem:4.47

corpus callosum/glia:4.62

pineal gland:-

peripheral nerve:5.17

spine:5.18

retina:-

eye:-

artery/aorta:6.35

vein:5.42

lymphnode:7.50

peripheral blood:-

spleen:9.45

thymus:6.08

bone marrow:7.18

adipose:6.11

bone:-

skin:5.68

CAGE

cerebrum:1.26

cerebellum:-

brain stem:2.35

corpus callosum/glia:2.25

pineal gland:1.77

peripheral nerve:-

spine:2.71

retina:-

eye:-

artery/aorta:4.31

vein:4.97

lymphnode:4.94

peripheral blood:-

spleen:5.14

thymus:3.90

bone marrow:-

adipose:3.05

bone:-

skin:-

RNA-seq

cerebrum:0.37

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:5.83

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:1.45

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:45.60

placenta:-

prostate:45.10

ovary:-

testis:-

heart:-

muscle:20.10

esophagus:-

stomach:127.50

intestine:64.80

colon:8.50

liver/hepato:-

lung:48.90

bladder:-

kidney:-

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:-

salivary:-

GeneChip

uterus:6.06

placenta:5.54

prostate:5.69

ovary:6.11

testis:4.48

heart:5.41

muscle:4.51

esophagus:5.85

stomach:7.12

intestine:6.60

colon:7.16

liver/hepato:6.93

lung:7.71

bladder:-

kidney:5.04

pituitary:4.74

thyroid/parathyroid:5.85

adrenal gland:5.62

pancreas:5.02

breast:6.04

salivary:5.71

CAGE

uterus:3.47

placenta:3.19

prostate:3.73

ovary:3.41

testis:2.38

heart:2.72

muscle:2.14

esophagus:3.34

stomach:-

intestine:5.16

colon:4.10

liver/hepato:3.03

lung:5.19

bladder:4.02

kidney:2.73

pituitary:1.55

thyroid/parathyroid:2.38

adrenal gland:-

pancreas:2.66

breast:2.41

salivary:3.22

RNA-seq

uterus:-

placenta:-

prostate:2.99

ovary:2.75

testis:1.68

heart:1.10

muscle:0.78

esophagus:-

stomach:-

intestine:-

colon:2.49

liver/hepato:1.81

lung:6.00

bladder:-

kidney:0.84

pituitary:-

thyroid/parathyroid:0.98

adrenal gland:5.31

pancreas:-

breast:2.56

salivary:-

IDs

Refseq ID	NM_002985
Gene ID	6352
Unigene ID	Hs.514821
Probe set ID	204655_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000161570
GTEx ID	ENSG00000161570

Orthologous Gene

Mouse[1]	NM_013653
Rat [0]

Chromosomal Region

17q12 [34,198,495 - 34,207,797]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR001811

Small chemokine, interleukin-8-like

Gene Ontology (GO ID)

Biological Process

GO:0031584	activation of phospholipase D activity
GO:0006816	calcium ion transport
GO:0007267	cell-cell signaling
GO:0006874	cellular calcium ion homeostasis
GO:0043623	cellular protein complex assembly
GO:0071346	cellular response to interferon-gamma
GO:0071347	cellular response to interleukin-1
GO:0071407	cellular response to organic cyclic substance
GO:0071356	cellular response to tumor necrosis factor
GO:0070098	chemokine-mediated signaling pathway
GO:0006935	chemotaxis
GO:0002407	dendritic cell chemotaxis
GO:0048245	eosinophil chemotaxis
GO:0006887	exocytosis
GO:0006954	inflammatory response
GO:0007159	leukocyte adhesion
GO:0031663	lipopolysaccharide-mediated signaling pathway
GO:0048246	macrophage chemotaxis
GO:0000165	MAPKKK cascade
GO:0002548	monocyte chemotaxis
GO:0043922	negative regulation by host of viral transcription
GO:0070100	negative regulation of chemokine-mediated signaling pathway
GO:0045744	negative regulation of G-protein coupled receptor protein signaling pathway
GO:0070233	negative regulation of T cell apoptosis
GO:0045071	negative regulation of viral genome replication
GO:0042119	neutrophil activation
GO:0050918	positive chemotaxis
GO:0010535	positive regulation of activation of JAK2 kinase activity
GO:0051928	positive regulation of calcium ion transport
GO:0045785	positive regulation of cell adhesion
GO:0030335	positive regulation of cell migration
GO:0033634	positive regulation of cell-cell adhesion mediated by integrin
GO:0031328	positive regulation of cellular biosynthetic process
GO:0034112	positive regulation of homotypic cell-cell adhesion
GO:0045089	positive regulation of innate immune response
GO:0046427	positive regulation of JAK-STAT cascade
GO:0010759	positive regulation of macrophage chemotaxis
GO:0090026	positive regulation of monocyte chemotaxis
GO:0014068	positive regulation of phosphoinositide 3-kinase cascade
GO:0042327	positive regulation of phosphorylation
GO:0014911	positive regulation of smooth muscle cell migration
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0070234	positive regulation of T cell apoptosis
GO:0010820	positive regulation of T cell chemotaxis
GO:0042102	positive regulation of T cell proliferation
GO:0045948	positive regulation of translational initiation
GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein
GO:0045070	positive regulation of viral genome replication
GO:0006468	protein amino acid phosphorylation
GO:0043491	protein kinase B signaling cascade
GO:0051262	protein tetramerization
GO:0002676	regulation of chronic inflammatory response
GO:0050863	regulation of T cell activation
GO:0009636	response to toxin
GO:0009615	response to virus

Cellular Component

GO:0005737	cytoplasm
GO:0005576	extracellular region
GO:0005615	extracellular space

Molecular Function

GO:0031726	CCR1 chemokine receptor binding
GO:0031729	CCR4 chemokine receptor binding
GO:0031730	CCR5 chemokine receptor binding
GO:0042056	chemoattractant activity
GO:0008009	chemokine activity
GO:0046817	chemokine receptor antagonist activity
GO:0042379	chemokine receptor binding
GO:0004435	phosphoinositide phospholipase C activity
GO:0016004	phospholipase activator activity
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0004672	protein kinase activity
GO:0043621	protein self-association
GO:0030298	receptor signaling protein tyrosine kinase activator activity

chemokine (C-C motif) ligand 5

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function