nucleotide-binding oligomerization domain containing 2

jump to detail

Synonym

caspase recruitment domain family, member 15, Caspase recruitment domain-containing protein 15, ACUG, NOD2B, Protein Nod2, CARD15, NOD2, BLAU, PSORAS1, IBD1, Inflammatory bowel disease protein 1

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:1.20 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:18.90 thymus:- bone marrow:39.40 adipose:- bone:- skin:4.80
GeneChip cerebrum:3.67 cerebellum:3.69 brain stem:3.68 corpus callosum/glia:3.59 pineal gland:- peripheral nerve:3.78 spine:3.65 retina:- eye:- artery/aorta:4.01 vein:3.73 lymphnode:4.45 peripheral blood:- spleen:4.51 thymus:3.73 bone marrow:5.11 adipose:4.18 bone:- skin:5.65
CAGE cerebrum:0.22 cerebellum:- brain stem:0.44 corpus callosum/glia:0.29 pineal gland:0.26 peripheral nerve:- spine:0.74 retina:- eye:- artery/aorta:1.10 vein:0.70 lymphnode:1.47 peripheral blood:- spleen:1.06 thymus:0.28 bone marrow:- adipose:0.78 bone:- skin:-
RNA-seq cerebrum:0.20 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.57 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.27 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:7.30 prostate:- ovary:- testis:- heart:12.80 muscle:- esophagus:- stomach:- intestine:- colon:8.50     liver/hepato:-        lung:4.90    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:4.07 placenta:3.87 prostate:3.74 ovary:3.79 testis:3.65 heart:3.76 muscle:3.75 esophagus:5.59 stomach:3.89 intestine:4.09 colon:3.95 liver/hepato:3.65 lung:4.47 bladder:- kidney:3.62 pituitary:3.54 thyroid/parathyroid:3.66 adrenal gland:3.77 pancreas:3.78 breast:4.18 salivary:4.52
CAGE uterus:0.71 placenta:0.81 prostate:0.62 ovary:0.47 testis:0.38 heart:0.78 muscle:0.24 esophagus:1.85 stomach:- intestine:0.07 colon:0.18     liver/hepato:0.46    lung:1.54 bladder:1.02 kidney:0.27 pituitary:0.19 thyroid/parathyroid:0.23 adrenal gland:- pancreas:0 breast:0 salivary:1.00
RNA-seq uterus:- placenta:- prostate:0.28 ovary:0.57 testis:0.39 heart:0.16 muscle:0.36 esophagus:- stomach:- intestine:- colon:0.11     liver/hepato:0.10        lung:1.67    bladder:- kidney:0.27 pituitary:- thyroid/parathyroid:0.22 adrenal gland:0.68 pancreas:- breast:0.18 salivary:-

IDs

Refseq ID NM_022162
Gene ID 64127
Unigene ID Hs.592072
Probe set ID 220066_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000167207
GTEx ID ENSG00000167207

Orthologous Gene

Mouse[1]  NM_145857
Rat [0]  

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed  (Pubmed ID)

7809109
8587604
8894707
9541106
9797359
9924607
10053016
10439963
11087742
11318544
11385576
11385577
11425413
11472070
11528384
11752413
11834373
11837220
11875755
11890351
11910336
11910337
11938034
11976792
12019209
12019468
12020527
12105836
12105838
12115195
12115249
12198692
12202985
12210321
12360101
12397216
12415614
12454871
12459523
12474146
12492195
12508397
12512038
12512064
12514169
12527755
12529700
12532667
12556233
12563685
12577202
12595627
12595906
12617879
12618963
12626759
12631666
12631668
12631669
12649405
12650796
12671896
12671897
12673278
12704363
12810925
12823148
12851870
12871942
12876263
12879366
12923865
12930309
12940436
13680285
14508222
14516815
14522785
14555911
14597055
14627676
14638352
14644139
14690304
14743885
14747834
14750643
14971813
14996717
15002819
15008984
15016407
15024686
15044951
15046221
15046222
15052696
15056084
15075345
15090455
15095853
15107016
15107849
15140210
15142196
15145460
15168811
15180737
15190267
15194649
15202784
15214053
15276183
15279649
15289769
15308523
15320482
15367194
15377357
15459013
15468360
15472511
15479689
15489579
15492242
15515785
15516360
15520108
15527324
15539411
15539413
15551253
15571586
15571588
15578724
15620648
15626887
15626888
15637755
15638227
15643611
15653568
15654786
15655821
15666202
15667501
15685536
15712650
15753091
15770725
15778542
15785318
15795594
15800781
15803022
15807862
15812565
15840263
15842589
15843082
15927452
15930978
15967635
15967716
15973116
15973118
15984988
15990626
15998797
16000642
16002353
16008671
16009674
16010583
16080653
16115863
16126943
16133971
16134725
16134731
16148063
16161956
16167972
16174099
16179784
16198136
16203728
16230083
16239840
16239841
16244543
16255050
16257953
16260731
16266221
16267612
16278823
16279904
16306764
16315780
16319062
16344053
16344054
16385250
16389181
16393227
16397396
16402184
16414084
16416181
16424393
16436969
16437636
16437728
16441470
16446977
16454837
16461743
16485124
16489646
16492792
16493424
16493449
16494109
16494592
16510569
16519819
16522788
16534418
16611251
16614992
16641610
16642031
16669960
16670523
16670524
16714539
16716969
16741608
16771961
16773683
16804398
16804670
16819374
16825909
16840031
16897777
16907704
16920047
16933467
16949315
16952484
16965521
16977346
17005562
17006998
17009307
17012967
17018387
17020469
17030188
17057186
17058067
17068223
17096091
17100974
17100976
17101573
17113749
17119385
17131470
17142621
17156146
17156193
17157607
17160430
17171451
17174426
17187069
17200669
17206080
17206636
17206688
17258734
17269998
17278126
17285593
17301648
17303577
17319929
17333217
17337451
17337463
17348859
17351900
17355968
17356065
17379562
17389014
17389035
17393391
17403538
17404888
17417801
17420470
17435756
17447842
17451203
17452051
17460484
17476680
17484863
17484864
17486745
17489054
17498224
17509030
17538984
17548659
17554300
17558494
17558906
17563761
17565648
17570063
17595233
17600378
17613538
17620097
17652449
17660460
17661913
17666747
17684544
17690884
17703412
17705850
17719742
17724347
17725592
17763471
17786191
17804789
17852840
17876878
17877509
17892524
17894849
17907287
17911997
17919942
17941079
17964196
17964870
17965022
17968944
17976376
17978873
17980027
18022867
18022871
18028374
18047543
18052659
18069758
18088053
18090989
18092344
18092345
18096043
18157816
18158963
18162085
18166373
18182678
18184136
18200509
18200510
18213697
18219096
18227809
18240302
18243161
18248772
18253730
18256385
18271063
18305068
18317454
18329614
18340358
18341489
18367950
18371139
18371140
18382655
18383179
18384487
18413660
18419343
18433468
18438406
18466472
18489434
18507017
18521914
18521924
18541930
18563169
18573991
18574154
18576390
18587394
18594982
18617779
18619921
18633131
18640012
18647548
18670786
18676680
18680223
18698678
18715515
18756601
18758419
18758464
18787464
18804983
18818748
18819462
18824555
18855982
18938111
18942751
18942754
18972554
18976442
18985712
19019335
19050632
19058231
19074885
19079230
19098858
19103524
19103559
19112191
19116920
19120480
19139201
19169908
19170196
19174806
19183163
19184348
19184350
19189651
19200604
19219079
19235913
19240061
19244164
19247692
19253375
19258923
19262523
19266573
19273470
19275920
19299732
19305026
19319132
19337309
19337385
19349988
19397946
19406482
19422935
19423540
19426395
19434699
19479836
19479837
19482182
19527514
19535145
19570052
19570976
19572373
19579027
19579029
19590455
19592251
19625176
19638967
19641059
19659808
19664207
19667203
19679065
19679608
19692168
19693669
19701189
19701969
19713276
19721713
19728064
19748964
19759286
19760754
19787357
19809335
19822951
19826411
19830732
19843337
19853919
19880660
19888426
19896081
19898471
19907652
19912254
19913121
19948723
19966812
20002790
20018961
20024904
20027650
20032092
20047977
20066736
20079790
20082483
20087966
20110711
20124104
20140262
20155851
20177049
20182871
20230816
20232407
20298285
20332463
20346235
20350193
20362271
20371648
20373538
20379614
20380008
20384614
20385562
20387682
20403997
20406964
20412372
20428899
20436512
20438785
20441518
20452482
20453000
20483763
20485703
20503287
20524760
20525885
20537165
20541026
20549515
20565245
20570966
20583427
20595247
20601676
20622911
20628086
20632099
20637199
20646002
20646321
20673868
20676658
20698950
20713205
20800603
20839241
20844241
20850627
20854823
20865702
20875485
20886065
20940596
20959815
20962850
21039068
21040192
21040358
21042538
21097508
21102463
21123652
21155887
21206965
21209938
21215810
21218092
21241317
21263023
21274544
21310790
21335489
21337670
21342182
21343918
21385537
21388357
21391291
21410503
21448648
21460759
21565239
21573891
21596301
21625457
21659536
21665963
21690088
21699783
21716313
21730793
21734346
21734790
21739538
21744420
21745302
21745515
21768114
21799103
21887730
21906983
21914217
21943069
21978001
22139875
22147245
22212192
22218461
22244368
22266421
22275320
22286692
22289211
22319155
22346247
22397822
22412388
22416979
22426692
22464675
22502597
22504414
22509093
22549783
22563200
22571967
22607974
22665475
22684479
22700971
22719818
22730064
22739221
22795647
22807259
22815893
22829933
22879519
22936669
22997500
22998942
23019338
23085276
23100559
23102769
23109427
23121969
23128233
23173613
23287275
23300079
23322906
23409731
23437331
23493074
23558906
23594678
23615072
23651603
23709157
23711367
23712977
23740944
23818254
23824692
23850724
23868940
23872065
23888881
23892590
23901396
23991106
24015287
24018334
24047397
24054330
24076061
24098051
24099766
24295830
24298015
24366254
24695226

Gene Ontology  (GO ID)

Biological Process

GO:0000187  activation of MAPK activity
GO:0071224  cellular response to peptidoglycan
GO:0002367  cytokine production during immune response
GO:0006952  defense response
GO:0042742  defense response to bacterium
GO:0050830  defense response to Gram-positive bacterium
GO:0016045  detection of bacterium
GO:0009595  detection of biotic stimulus
GO:0032498  detection of muramyl dipeptide
GO:0002381  immunoglobulin production during immune response
GO:0045087  innate immune response
GO:0002227  innate immune response in mucosa
GO:0007254  JNK cascade
GO:0002282  microglial cell activation during immune response
GO:0002755  MyD88-dependent toll-like receptor signaling pathway
GO:0002756  MyD88-independent toll-like receptor signaling pathway
GO:0044130  negative regulation of growth of symbiont in host
GO:0002862  negative regulation of inflammatory response to antigenic stimulus
GO:0032689  negative regulation of interferon-gamma production
GO:0032695  negative regulation of interleukin-12 production
GO:0032701  negative regulation of interleukin-18 production
GO:0032703  negative regulation of interleukin-2 production
GO:0032088  negative regulation of NF-kappaB transcription factor activity
GO:0002710  negative regulation of T cell mediated immunity
GO:0034136  negative regulation of toll-like receptor 2 signaling pathway
GO:0032720  negative regulation of tumor necrosis factor production
GO:0070431  nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0070423  nucleotide-binding oligomerization domain containing signaling pathway
GO:0052033  pathogen-associated molecular pattern dependent induction by symbiont of host innate immunity
GO:0050871  positive regulation of B cell activation
GO:0006965  positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
GO:0002606  positive regulation of dendritic cell antigen processing and presentation
GO:0002732  positive regulation of dendritic cell cytokine production
GO:0050679  positive regulation of epithelial cell proliferation
GO:0070374  positive regulation of ERK1 and ERK2 cascade
GO:0046645  positive regulation of gamma-delta T cell activation
GO:0002925  positive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0043123  positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0032731  positive regulation of interleukin-1 beta production
GO:0050718  positive regulation of interleukin-1 beta secretion
GO:0032733  positive regulation of interleukin-10 production
GO:0032735  positive regulation of interleukin-12 production
GO:0032740  positive regulation of interleukin-17 production
GO:0032755  positive regulation of interleukin-6 production
GO:0046330  positive regulation of JNK cascade
GO:0051092  positive regulation of NF-kappaB transcription factor activity
GO:0051770  positive regulation of nitric-oxide synthase biosynthetic process
GO:0045747  positive regulation of Notch signaling pathway
GO:0051353  positive regulation of oxidoreductase activity
GO:0050731  positive regulation of peptidyl-tyrosine phosphorylation
GO:0050766  positive regulation of phagocytosis
GO:0043552  positive regulation of phosphoinositide 3-kinase activity
GO:0060585  positive regulation of prostaglandin-endoperoxidase synthase activity
GO:0032874  positive regulation of stress-activated MAPK cascade
GO:0002830  positive regulation of T-helper 2 type immune response
GO:0032760  positive regulation of tumor necrosis factor production
GO:0051259  protein oligomerization
GO:0050727  regulation of inflammatory response
GO:0090022  regulation of neutrophil chemotaxis
GO:0043330  response to exogenous dsRNA
GO:0032496  response to lipopolysaccharide
GO:0032495  response to muramyl dipeptide
GO:0007584  response to nutrient
GO:0051403  stress-activated MAPK cascade
GO:0034166  toll-like receptor 10 signaling pathway
GO:0034134  toll-like receptor 2 signaling pathway
GO:0034138  toll-like receptor 3 signaling pathway
GO:0034142  toll-like receptor 4 signaling pathway
GO:0034146  toll-like receptor 5 signaling pathway
GO:0034162  toll-like receptor 9 signaling pathway
GO:0002224  toll-like receptor signaling pathway

Cellular Component

GO:0009986  cell surface
GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0005886  plasma membrane
GO:0008180  signalosome
GO:0031982  vesicle

Molecular Function

GO:0005524  ATP binding
GO:0050700  CARD domain binding
GO:0019899  enzyme binding
GO:0032500  muramyl dipeptide binding
GO:0042834  peptidoglycan binding
GO:0005515  protein binding
GO:0019901  protein kinase binding