nucleotide-binding oligomerization domain containing 2

Synonym

caspase recruitment domain family, member 15, Caspase recruitment domain-containing protein 15, ACUG, NOD2B, Protein Nod2, CARD15, NOD2, BLAU, PSORAS1, IBD1, Inflammatory bowel disease protein 1

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:1.20

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:18.90

thymus:-

bone marrow:39.40

adipose:-

bone:-

skin:4.80

GeneChip

cerebrum:3.67

cerebellum:3.69

brain stem:3.68

corpus callosum/glia:3.59

pineal gland:-

peripheral nerve:3.78

spine:3.65

retina:-

eye:-

artery/aorta:4.01

vein:3.73

lymphnode:4.45

peripheral blood:-

spleen:4.51

thymus:3.73

bone marrow:5.11

adipose:4.18

bone:-

skin:5.65

CAGE

cerebrum:0.22

cerebellum:-

brain stem:0.44

corpus callosum/glia:0.29

pineal gland:0.26

peripheral nerve:-

spine:0.74

retina:-

eye:-

artery/aorta:1.10

vein:0.70

lymphnode:1.47

peripheral blood:-

spleen:1.06

thymus:0.28

bone marrow:-

adipose:0.78

bone:-

skin:-

RNA-seq

cerebrum:0.20

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:1.57

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:0.27

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:-

placenta:7.30

prostate:-

ovary:-

testis:-

heart:12.80

muscle:-

esophagus:-

stomach:-

intestine:-

colon:8.50

liver/hepato:-

lung:4.90

bladder:-

kidney:-

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:-

salivary:-

GeneChip

uterus:4.07

placenta:3.87

prostate:3.74

ovary:3.79

testis:3.65

heart:3.76

muscle:3.75

esophagus:5.59

stomach:3.89

intestine:4.09

colon:3.95

liver/hepato:3.65

lung:4.47

bladder:-

kidney:3.62

pituitary:3.54

thyroid/parathyroid:3.66

adrenal gland:3.77

pancreas:3.78

breast:4.18

salivary:4.52

CAGE

uterus:0.71

placenta:0.81

prostate:0.62

ovary:0.47

testis:0.38

heart:0.78

muscle:0.24

esophagus:1.85

stomach:-

intestine:0.07

colon:0.18

liver/hepato:0.46

lung:1.54

bladder:1.02

kidney:0.27

pituitary:0.19

thyroid/parathyroid:0.23

adrenal gland:-

pancreas:0

breast:0

salivary:1.00

RNA-seq

uterus:-

placenta:-

prostate:0.28

ovary:0.57

testis:0.39

heart:0.16

muscle:0.36

esophagus:-

stomach:-

intestine:-

colon:0.11

liver/hepato:0.10

lung:1.67

bladder:-

kidney:0.27

pituitary:-

thyroid/parathyroid:0.22

adrenal gland:0.68

pancreas:-

breast:0.18

salivary:-

IDs

Refseq ID	NM_022162
Gene ID	64127
Unigene ID	Hs.592072
Probe set ID	220066_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000167207
GTEx ID	ENSG00000167207

Orthologous Gene

Mouse[1]	NM_145857
Rat [0]

Chromosomal Region

16q12.1 [50,727,514 - 50,766,987]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

LRG_177 [5,001 - 40,938]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR001315	Caspase Recruitment
IPR011029	DEATH-like

Gene Ontology (GO ID)

Biological Process

GO:0000187	activation of MAPK activity
GO:0071224	cellular response to peptidoglycan
GO:0002367	cytokine production during immune response
GO:0006952	defense response
GO:0042742	defense response to bacterium
GO:0050830	defense response to Gram-positive bacterium
GO:0016045	detection of bacterium
GO:0009595	detection of biotic stimulus
GO:0032498	detection of muramyl dipeptide
GO:0002381	immunoglobulin production during immune response
GO:0045087	innate immune response
GO:0002227	innate immune response in mucosa
GO:0007254	JNK cascade
GO:0002282	microglial cell activation during immune response
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0002756	MyD88-independent toll-like receptor signaling pathway
GO:0044130	negative regulation of growth of symbiont in host
GO:0002862	negative regulation of inflammatory response to antigenic stimulus
GO:0032689	negative regulation of interferon-gamma production
GO:0032695	negative regulation of interleukin-12 production
GO:0032701	negative regulation of interleukin-18 production
GO:0032703	negative regulation of interleukin-2 production
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0002710	negative regulation of T cell mediated immunity
GO:0034136	negative regulation of toll-like receptor 2 signaling pathway
GO:0032720	negative regulation of tumor necrosis factor production
GO:0070431	nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0070423	nucleotide-binding oligomerization domain containing signaling pathway
GO:0052033	pathogen-associated molecular pattern dependent induction by symbiont of host innate immunity
GO:0050871	positive regulation of B cell activation
GO:0006965	positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
GO:0002606	positive regulation of dendritic cell antigen processing and presentation
GO:0002732	positive regulation of dendritic cell cytokine production
GO:0050679	positive regulation of epithelial cell proliferation
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0046645	positive regulation of gamma-delta T cell activation
GO:0002925	positive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0032731	positive regulation of interleukin-1 beta production
GO:0050718	positive regulation of interleukin-1 beta secretion
GO:0032733	positive regulation of interleukin-10 production
GO:0032735	positive regulation of interleukin-12 production
GO:0032740	positive regulation of interleukin-17 production
GO:0032755	positive regulation of interleukin-6 production
GO:0046330	positive regulation of JNK cascade
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process
GO:0045747	positive regulation of Notch signaling pathway
GO:0051353	positive regulation of oxidoreductase activity
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050766	positive regulation of phagocytosis
GO:0043552	positive regulation of phosphoinositide 3-kinase activity
GO:0060585	positive regulation of prostaglandin-endoperoxidase synthase activity
GO:0032874	positive regulation of stress-activated MAPK cascade
GO:0002830	positive regulation of T-helper 2 type immune response
GO:0032760	positive regulation of tumor necrosis factor production
GO:0051259	protein oligomerization
GO:0050727	regulation of inflammatory response
GO:0090022	regulation of neutrophil chemotaxis
GO:0043330	response to exogenous dsRNA
GO:0032496	response to lipopolysaccharide
GO:0032495	response to muramyl dipeptide
GO:0007584	response to nutrient
GO:0051403	stress-activated MAPK cascade
GO:0034166	toll-like receptor 10 signaling pathway
GO:0034134	toll-like receptor 2 signaling pathway
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0034146	toll-like receptor 5 signaling pathway
GO:0034162	toll-like receptor 9 signaling pathway
GO:0002224	toll-like receptor signaling pathway

Cellular Component

GO:0009986	cell surface
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0008180	signalosome
GO:0031982	vesicle

Molecular Function

GO:0005524	ATP binding
GO:0050700	CARD domain binding
GO:0019899	enzyme binding
GO:0032500	muramyl dipeptide binding
GO:0042834	peptidoglycan binding
GO:0005515	protein binding
GO:0019901	protein kinase binding

nucleotide-binding oligomerization domain containing 2

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function