interferon induced with helicase C domain 1

Synonym

Melanoma differentiation-associated protein 5, MDA5, interferon induced with helicase C domain 1, Helicase with 2 CARD domains, IFIH1, Helicard, Hlcd, MGC133047, Murabutide-down-regulated protein, MDA-5, RNA helicase-DEAD box protein 116, IDDM19, RH116

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:7.10

cerebellum:12.60

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:5.90

artery/aorta:89.90

vein:-

lymphnode:10.10

peripheral blood:109.30

spleen:18.90

thymus:64.40

bone marrow:19.70

adipose:40.30

bone:51.20

skin:24

GeneChip

cerebrum:4.77

cerebellum:4.39

brain stem:4.88

corpus callosum/glia:5.02

pineal gland:-

peripheral nerve:5.68

spine:5

retina:-

eye:-

artery/aorta:5.40

vein:5.29

lymphnode:6.11

peripheral blood:-

spleen:6.86

thymus:6.26

bone marrow:5.04

adipose:5.56

bone:-

skin:5.16

CAGE

cerebrum:1.58

cerebellum:-

brain stem:1.98

corpus callosum/glia:1.91

pineal gland:1.58

peripheral nerve:-

spine:2.26

retina:-

eye:-

artery/aorta:2.51

vein:2.99

lymphnode:2.94

peripheral blood:-

spleen:3.38

thymus:3.03

bone marrow:-

adipose:3.10

bone:-

skin:-

RNA-seq

cerebrum:1.43

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:3.07

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:1.83

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:27.30

placenta:18.20

prostate:22.50

ovary:-

testis:17.30

heart:-

muscle:-

esophagus:-

stomach:42.50

intestine:64.80

colon:25.40

liver/hepato:-

lung:78.20

bladder:125.60

kidney:31.20

pituitary:-

thyroid/parathyroid:-

adrenal gland:101.60

pancreas:8.90

breast:92.90

salivary:-

GeneChip

uterus:5.93

placenta:5.86

prostate:6.52

ovary:6.03

testis:4.89

heart:5.65

muscle:4.88

esophagus:5.66

stomach:5.57

intestine:5.22

colon:5.29

liver/hepato:6.05

lung:6.38

bladder:-

kidney:5.22

pituitary:5.65

thyroid/parathyroid:5.73

adrenal gland:5.65

pancreas:5.39

breast:5.49

salivary:5.91

CAGE

uterus:2.50

placenta:2.86

prostate:2.87

ovary:2.66

testis:1.71

heart:2.59

muscle:1.20

esophagus:2.57

stomach:-

intestine:3.07

colon:2.84

liver/hepato:2.61

lung:3.30

bladder:2.46

kidney:2.54

pituitary:2.62

thyroid/parathyroid:2.93

adrenal gland:-

pancreas:2.08

breast:2.64

salivary:1.15

RNA-seq

uterus:-

placenta:-

prostate:2.68

ovary:3.41

testis:2.68

heart:1.57

muscle:0.89

esophagus:-

stomach:-

intestine:-

colon:2.34

liver/hepato:1.92

lung:3.00

bladder:-

kidney:2.99

pituitary:-

thyroid/parathyroid:2.49

adrenal gland:2.78

pancreas:-

breast:2.37

salivary:-

IDs

Refseq ID	NM_022168
Gene ID	64135
Unigene ID	Hs.163173
Probe set ID	219209_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000115267
GTEx ID	ENSG00000115267

Orthologous Gene

Mouse[4]	NM_001164477, NM_027835
Rat[1]	NM_001109199, NM_027835

Chromosomal Region

2q24.2 [163,123,589 - 163,175,213]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR014001	DEAD-like helicase, N-terminal
IPR014021	Helicase, superfamily 1/2, ATP-binding domain

Gene Ontology (GO ID)

Biological Process

GO:0009597	detection of virus
GO:0045087	innate immune response
GO:0032480	negative regulation of type I interferon production
GO:0032727	positive regulation of interferon-alpha production
GO:0032728	positive regulation of interferon-beta production
GO:0016925	protein sumoylation
GO:0042981	regulation of apoptosis
GO:0034344	regulation of type III interferon production
GO:0009615	response to virus
GO:0019048	virus-host interaction

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005634	nucleus

Molecular Function

GO:0005524	ATP binding
GO:0003677	DNA binding
GO:0003725	double-stranded RNA binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0043021	ribonucleoprotein binding
GO:0003727	single-stranded RNA binding
GO:0008270	zinc ion binding

interferon induced with helicase C domain 1

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function