mitogen-activated protein kinase kinase 4

Synonym

MKK4, JNKK, MEK4, MAPKK4, MAP2K4, JNKK1, JNK-activating kinase 1, c-Jun N-terminal kinase kinase 1, mitogen-activated protein kinase kinase 4, SAPK/ERK kinase 1, SEK1, SERK1, PRKMK4, MAP kinase kinase 4

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:206.20

cerebellum:239.30

brain stem:-

corpus callosum/glia:29.20

pineal gland:-

peripheral nerve:-

spine:112.30

retina:-

eye:70.50

artery/aorta:89.90

vein:-

lymphnode:70.80

peripheral blood:18.20

spleen:56.70

thymus:51.50

bone marrow:19.70

adipose:-

bone:-

skin:38.40

GeneChip

cerebrum:5.55

cerebellum:5.22

brain stem:5.90

corpus callosum/glia:4.93

pineal gland:-

peripheral nerve:4.99

spine:5.14

retina:-

eye:-

artery/aorta:4.88

vein:4.92

lymphnode:4.79

peripheral blood:-

spleen:4.54

thymus:5.57

bone marrow:5.01

adipose:4.96

bone:-

skin:5.14

CAGE

cerebrum:4.74

cerebellum:-

brain stem:4.66

corpus callosum/glia:3.78

pineal gland:4.16

peripheral nerve:-

spine:4.56

retina:-

eye:-

artery/aorta:3.85

vein:3.54

lymphnode:3.75

peripheral blood:-

spleen:3.34

thymus:3.52

bone marrow:-

adipose:3.25

bone:-

skin:-

RNA-seq

cerebrum:4.76

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:2.94

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:2.72

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:36.50

placenta:58.30

prostate:78.90

ovary:37.30

testis:38.90

heart:12.80

muscle:20.10

esophagus:-

stomach:42.50

intestine:-

colon:33.90

liver/hepato:52.80

lung:44

bladder:125.60

kidney:72.80

pituitary:116

thyroid/parathyroid:-

adrenal gland:50.80

pancreas:26.70

breast:111.50

salivary:-

GeneChip

uterus:4.99

placenta:5.38

prostate:5.46

ovary:5.07

testis:4.95

heart:4.77

muscle:5

esophagus:5.17

stomach:4.71

intestine:4.98

colon:4.66

liver/hepato:4.69

lung:4.69

bladder:-

kidney:4.62

pituitary:4.96

thyroid/parathyroid:4.74

adrenal gland:4.53

pancreas:5.15

breast:4.99

salivary:4.72

CAGE

uterus:3.60

placenta:3.78

prostate:3.43

ovary:3.24

testis:3.58

heart:3.73

muscle:3.78

esophagus:3.54

stomach:-

intestine:3.38

colon:3.58

liver/hepato:3.44

lung:3.70

bladder:3.35

kidney:3.33

pituitary:4.17

thyroid/parathyroid:3.31

adrenal gland:-

pancreas:3.37

breast:3.80

salivary:2.95

RNA-seq

uterus:-

placenta:-

prostate:3.22

ovary:3.48

testis:3.37

heart:3.20

muscle:2.62

esophagus:-

stomach:-

intestine:-

colon:2.61

liver/hepato:2.91

lung:2.61

bladder:-

kidney:3.33

pituitary:-

thyroid/parathyroid:3.66

adrenal gland:3.07

pancreas:-

breast:2.97

salivary:-

IDs

Refseq ID	NM_003010
Gene ID	6416
Unigene ID	Hs.514681
Probe set ID	203265_s_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000065559
GTEx ID	ENSG00000065559

Orthologous Gene

Mouse[2]	NM_009157
Rat[1]	NM_001030023

Chromosomal Region

17p12 [11,924,135 - 12,047,050]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR000719	Protein kinase, catalytic domain
IPR011009	Protein kinase-like domain
IPR002290	Serine/threonine-protein kinase domain
IPR017442	Serine/threonine-protein kinase-like domain
IPR001245	Tyrosine-protein kinase, catalytic domain
IPR020635	Tyrosine-protein kinase, subgroup, catalytic domain

Gene Ontology (GO ID)

Biological Process

GO:0006915	apoptosis
GO:0071260	cellular response to mechanical stimulus
GO:0045087	innate immune response
GO:0007254	JNK cascade
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0002756	MyD88-independent toll-like receptor signaling pathway
GO:0007165	signal transduction
GO:0051403	stress-activated MAPK cascade
GO:0034166	toll-like receptor 10 signaling pathway
GO:0034134	toll-like receptor 2 signaling pathway
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0034146	toll-like receptor 5 signaling pathway
GO:0034162	toll-like receptor 9 signaling pathway
GO:0002224	toll-like receptor signaling pathway

Cellular Component

GO:0005829	cytosol
GO:0005634	nucleus

Molecular Function

GO:0005524	ATP binding
GO:0005515	protein binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity

mitogen-activated protein kinase kinase 4

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function