secreted frizzled-related protein 2

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Synonym

UNQ361/PRO697, FRP-2, SARP-1, Secreted apoptosis-related protein 1, SARP1, Secreted frizzled-related protein 2 precursor, SDF-5, secreted frizzled-related protein 2, sFRP-2, Frizzled-related protein 2, FKSG12, FRP2, SFRP2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:66.40 cerebellum:12.60 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:245.40 spine:112.30 retina:- eye:111.70 artery/aorta:299.80 vein:- lymphnode:- peripheral blood:- spleen:- thymus:154.60 bone marrow:- adipose:161.30 bone:38.40 skin:38.40
GeneChip nodata
CAGE cerebrum:2.61 cerebellum:- brain stem:2.53 corpus callosum/glia:4.08 pineal gland:2.64 peripheral nerve:- spine:3.15 retina:- eye:- artery/aorta:6.07 vein:6.19 lymphnode:2.57 peripheral blood:- spleen:0.76 thymus:1.22 bone marrow:- adipose:3.58 bone:- skin:-
RNA-seq cerebrum:4.03 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:5.52 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.73 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:82 placenta:21.90 prostate:123.90 ovary:74.50 testis:8.70 heart:242.70 muscle:20.10 esophagus:342.80 stomach:127.50 intestine:907.10 colon:25.40     liver/hepato:-        lung:205.30    bladder:1130.50 kidney:20.80 pituitary:- thyroid/parathyroid:327.50 adrenal gland:- pancreas:44.50 breast:92.90 salivary:-
GeneChip nodata
CAGE uterus:3.83 placenta:0.92 prostate:5.14 ovary:3.67 testis:3.35 heart:3.22 muscle:2.59 esophagus:5.20 stomach:- intestine:4.04 colon:4.79     liver/hepato:0.46    lung:4.52 bladder:5.56 kidney:2.28 pituitary:2.91 thyroid/parathyroid:3.33 adrenal gland:- pancreas:4.60 breast:5.86 salivary:3.35
RNA-seq uterus:- placenta:- prostate:7.00 ovary:2.17 testis:4.76 heart:1.11 muscle:2.08 esophagus:- stomach:- intestine:- colon:6.14     liver/hepato:0.04        lung:5.96    bladder:- kidney:2.09 pituitary:- thyroid/parathyroid:4.50 adrenal gland:3.76 pancreas:- breast:6.10 salivary:-

Gene Information

IDs

Refseq ID NM_003013
Gene ID 6423
Unigene ID Hs.481022
Probe set ID -
Ensembl ID ENSG00000145423
GTEx ID ENSG00000145423

Orthologous Gene

Mouse[1]  NM_009144
Rat[1]  NM_001100700

Chromosomal Region

4q31.3  [154,701,744  -  154,710,272]

Gene Family (Interpro ID)

IPR020067  Frizzled-like domain
IPR001134  Netrin domain
IPR018933  Netrin module, non-TIMP type
IPR008993  TIMP-like, OB-fold

Link to Pubmed  (Pubmed ID)

9096311
9391078
9642118
9853965
10072424
10654605
10980594
12055200
12477932
12975309
14561758
14702039
14709558
15094274
15146197
15340161
15489334
16303743
16407829
16609023
17081983
17352030
17410438
17471511
17639423
17848950
18029348
18079202
18404682
18497987
18528941
18592156
18795670
18990230
19095296
19299079
19389651
19453261
19458075
19513569
19593212
19926868
19946729
20030932
20208569
20403915
20501806
20596629
20602801
20682398
20686305
20723538
20795789
20811686
21174795
21409489
21463549
21490961
21709714
22136354
22175903
22246241
22363119
22915211
23215838
23226515
24464051

Gene Ontology  (GO ID)

Biological Process

GO:0060349  bone morphogenesis
GO:0007420  brain development
GO:0003214  cardiac left ventricle morphogenesis
GO:0007267  cell-cell signaling
GO:0031668  cellular response to extracellular stimulus
GO:0071481  cellular response to X-ray
GO:0002063  chondrocyte development
GO:0030199  collagen fibril organization
GO:0060028  convergent extension involved in axis elongation
GO:0048546  digestive tract morphogenesis
GO:0009790  embryonic development
GO:0042733  embryonic digit morphogenesis
GO:0008406  gonad development
GO:0071425  hemopoietic stem cell proliferation
GO:0008584  male gonad development
GO:0030514  negative regulation of BMP signaling pathway
GO:0010667  negative regulation of cardiac muscle cell apoptosis
GO:0043154  negative regulation of caspase activity
GO:0030308  negative regulation of cell growth
GO:0030336  negative regulation of cell migration
GO:0008285  negative regulation of cell proliferation
GO:0050680  negative regulation of epithelial cell proliferation
GO:0010719  negative regulation of epithelial to mesenchymal transition
GO:0010629  negative regulation of gene expression
GO:0043508  negative regulation of JUN kinase activity
GO:0042662  negative regulation of mesodermal cell fate specification
GO:0050732  negative regulation of peptidyl-tyrosine phosphorylation
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0030178  negative regulation of Wnt receptor signaling pathway
GO:0090090  negative regulation of Wnt receptor signaling pathway through beta-catenin
GO:0001843  neural tube closure
GO:0003151  outflow tract morphogenesis
GO:0001569  patterning of blood vessels
GO:0090179  planar cell polarity pathway involved in neural tube closure
GO:0045766  positive regulation of angiogenesis
GO:0043065  positive regulation of apoptosis
GO:0033630  positive regulation of cell adhesion mediated by integrin
GO:0030307  positive regulation of cell growth
GO:0008284  positive regulation of cell proliferation
GO:0045600  positive regulation of fat cell differentiation
GO:0045669  positive regulation of osteoblast differentiation
GO:0033138  positive regulation of peptidyl-serine phosphorylation
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0042493  response to drug
GO:0001944  vasculature development

Cellular Component

GO:0042995  cell projection
GO:0005737  cytoplasm
GO:0031012  extracellular matrix
GO:0005615  extracellular space
GO:0005886  plasma membrane

Molecular Function

GO:0001968  fibronectin binding
GO:0005178  integrin binding
GO:0010577  metalloenzyme activator activity
GO:0030165  PDZ domain binding
GO:0048018  receptor agonist activity
GO:0042813  Wnt receptor activity
GO:0017147  Wnt-protein binding