intersectin 1 (SH3 domain protein)

Synonym

SH3 domain-containing protein 1A, SH3P17, MGC134949, MGC134948, Intersectin-1, SH3D1A, ITSN1, intersectin 1 (SH3 domain protein), ITSN

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:66.40

cerebellum:37.80

brain stem:-

corpus callosum/glia:175

pineal gland:-

peripheral nerve:122.70

spine:224.60

retina:355.90

eye:105.80

artery/aorta:149.90

vein:133.30

lymphnode:-

peripheral blood:-

spleen:37.80

thymus:-

bone marrow:98.40

adipose:161.30

bone:64

skin:43.20

GeneChip

cerebrum:7.28

cerebellum:7.10

brain stem:7.18

corpus callosum/glia:7.43

pineal gland:-

peripheral nerve:7.95

spine:7.62

retina:-

eye:-

artery/aorta:7.92

vein:8.16

lymphnode:7.21

peripheral blood:-

spleen:7.39

thymus:6.73

bone marrow:7.40

adipose:8.55

bone:-

skin:7.81

CAGE

cerebrum:3.86

cerebellum:-

brain stem:3.64

corpus callosum/glia:3.29

pineal gland:3.85

peripheral nerve:-

spine:3.67

retina:-

eye:-

artery/aorta:3.38

vein:3.17

lymphnode:2.02

peripheral blood:-

spleen:2.91

thymus:1.92

bone marrow:-

adipose:4.17

bone:-

skin:-

RNA-seq

cerebrum:2.72

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:3.11

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:4.57

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:91.10

placenta:43.70

prostate:45.10

ovary:-

testis:34.60

heart:140.50

muscle:20.10

esophagus:342.80

stomach:21.20

intestine:32.40

colon:50.90

liver/hepato:137.20

lung:44

bladder:-

kidney:20.80

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:62.20

breast:102.20

salivary:-

GeneChip

uterus:8.03

placenta:7.95

prostate:7.51

ovary:7.81

testis:7.38

heart:7.82

muscle:7.91

esophagus:7.23

stomach:7.47

intestine:7.31

colon:7.16

liver/hepato:7.73

lung:7.32

bladder:-

kidney:7.23

pituitary:7.10

thyroid/parathyroid:7.41

adrenal gland:7.63

pancreas:7.17

breast:8.03

salivary:7.16

CAGE

uterus:3.62

placenta:2.97

prostate:3.46

ovary:3.26

testis:2.90

heart:3.44

muscle:3.01

esophagus:2.97

stomach:-

intestine:3.07

colon:3.01

liver/hepato:3.53

lung:2.77

bladder:3.49

kidney:3.16

pituitary:2.69

thyroid/parathyroid:3.03

adrenal gland:-

pancreas:1.74

breast:3.95

salivary:2.31

RNA-seq

uterus:-

placenta:-

prostate:3.84

ovary:3.61

testis:3.86

heart:3.31

muscle:3.20

esophagus:-

stomach:-

intestine:-

colon:3.48

liver/hepato:2.96

lung:2.73

bladder:-

kidney:3.28

pituitary:-

thyroid/parathyroid:2.69

adrenal gland:2.84

pancreas:-

breast:5.27

salivary:-

IDs

Refseq ID	NM_001001132
Gene ID	6453
Unigene ID	Hs.160324
Probe set ID	209297_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000205726
GTEx ID	ENSG00000205726

Orthologous Gene

Mouse[7]	NM_001110275, NM_001110276, NM_010587
Rat[2]	NM_001136096, NM_019227, NM_010587

Chromosomal Region

21q22.11 [35,014,706 - 35,272,165]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR000008	C2 calcium-dependent membrane targeting
IPR008973	C2 calcium/lipid-binding domain, CaLB
IPR018029	C2 membrane targeting protein
IPR002048	Calcium-binding EF-hand
IPR018249	EF-HAND 2
IPR001849	Pleckstrin homology
IPR013315	Spectrin alpha chain, SH3 domain
IPR020473	Src homology-3, region

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

GO:0043524	negative regulation of neuron apoptosis
GO:0048011	nerve growth factor receptor signaling pathway
GO:0043065	positive regulation of apoptosis
GO:0051897	positive regulation of protein kinase B signaling cascade
GO:0035023	regulation of Rho protein signal transduction
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0048488	synaptic vesicle endocytosis

Cellular Component

GO:0030054	cell junction
GO:0005905	coated pit
GO:0005829	cytosol
GO:0030139	endocytic vesicle
GO:0030027	lamellipodium
GO:0043005	neuron projection
GO:0005886	plasma membrane
GO:0045202	synapse

Molecular Function

GO:0005509	calcium ion binding
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0019209	kinase activator activity
GO:0005543	phospholipid binding
GO:0070064	proline-rich region binding
GO:0005515	protein binding
GO:0032947	protein complex scaffold
GO:0005089	Rho guanyl-nucleotide exchange factor activity

intersectin 1 (SH3 domain protein)

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function