SMAD specific E3 ubiquitin protein ligase 2

Synonym

Smad-specific E3 ubiquitin ligase 2, SMURF-2, MGC138150, SMURF 2, Smurf-2, hSMURF2, SMURF2, Smad ubiquitination regulatory factor 2, Ubiquitin--protein ligase SMURF2, SMAD specific E3 ubiquitin protein ligase 2, Smurf 2

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

nodata

GeneChip

cerebrum:6.23

cerebellum:6.23

brain stem:5.89

corpus callosum/glia:6.81

pineal gland:-

peripheral nerve:6.40

spine:6.50

retina:-

eye:-

artery/aorta:6.75

vein:7.14

lymphnode:7.20

peripheral blood:-

spleen:7.68

thymus:7.24

bone marrow:6.29

adipose:7.01

bone:-

skin:6.42

CAGE

cerebrum:2.52

cerebellum:-

brain stem:2.54

corpus callosum/glia:2.85

pineal gland:2.50

peripheral nerve:-

spine:2.48

retina:-

eye:-

artery/aorta:2.83

vein:2.78

lymphnode:2.43

peripheral blood:-

spleen:2.47

thymus:2.43

bone marrow:-

adipose:2.35

bone:-

skin:-

RNA-seq

cerebrum:2.13

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:2.68

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:2.62

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

nodata

GeneChip

uterus:7.13

placenta:7.19

prostate:7.51

ovary:7.46

testis:7.94

heart:6.62

muscle:5.71

esophagus:6.02

stomach:7.36

intestine:6.95

colon:6.31

liver/hepato:5.63

lung:8.73

bladder:-

kidney:6.89

pituitary:5.65

thyroid/parathyroid:7.40

adrenal gland:7.15

pancreas:5.91

breast:7.16

salivary:6.86

CAGE

uterus:2.62

placenta:2.61

prostate:2.61

ovary:2.52

testis:3.11

heart:2.39

muscle:2.05

esophagus:2.37

stomach:-

intestine:2.51

colon:2.71

liver/hepato:1.29

lung:2.97

bladder:2.38

kidney:2.06

pituitary:2.36

thyroid/parathyroid:2.44

adrenal gland:-

pancreas:1.87

breast:2.41

salivary:2.12

RNA-seq

uterus:-

placenta:-

prostate:2.77

ovary:2.72

testis:3.79

heart:1.80

muscle:1.42

esophagus:-

stomach:-

intestine:-

colon:2.66

liver/hepato:0.70

lung:3.46

bladder:-

kidney:2.49

pituitary:-

thyroid/parathyroid:2.97

adrenal gland:2.44

pancreas:-

breast:2.75

salivary:-

IDs

Refseq ID	NM_022739
Gene ID	64750
Unigene ID	-
Probe set ID	205596_s_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000108854
GTEx ID	ENSG00000108854

Orthologous Gene

Mouse[1]	NM_025481
Rat [0]

Chromosomal Region

17q24.1 [62,540,735 - 62,658,386]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR000008	C2 calcium-dependent membrane targeting
IPR008973	C2 calcium/lipid-binding domain, CaLB
IPR018029	C2 membrane targeting protein
IPR001202	WW/Rsp5/WWP

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

GO:0030509	BMP signaling pathway
GO:0010467	gene expression
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0045892	negative regulation of transcription, DNA-dependent
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0042787	protein ubiquitination during ubiquitin-dependent protein catabolic process
GO:0017015	regulation of transforming growth factor beta receptor signaling pathway
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006351	transcription, DNA-dependent
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0030579	ubiquitin-dependent SMAD protein catabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0045121	membrane raft
GO:0005654	nucleoplasm
GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0000151	ubiquitin ligase complex

Molecular Function

GO:0042802	identical protein binding
GO:0005515	protein binding
GO:0046332	SMAD binding
GO:0005160	transforming growth factor beta receptor binding
GO:0004842	ubiquitin-protein ligase activity

SMAD specific E3 ubiquitin protein ligase 2

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function