bone morphogenetic protein 2

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Synonym

bone morphogenetic protein 2, BMP2A, BMP-2A, Bone morphogenetic protein 2 precursor, BMP 2, BMP2, BMP-2

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:3.60

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:30.70

spine:-

retina:-

eye:52.90

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:37.80

thymus:-

bone marrow:-

adipose:-

bone:25.60

skin:57.60

GeneChip

cerebrum:4.88

cerebellum:4.40

brain stem:4.99

corpus callosum/glia:5.12

pineal gland:-

peripheral nerve:5.19

spine:5.24

retina:-

eye:-

artery/aorta:6.34

vein:6.18

lymphnode:5.66

peripheral blood:-

spleen:7.93

thymus:4.12

bone marrow:5.09

adipose:6.37

bone:-

skin:6.40

CAGE

cerebrum:0.47

cerebellum:-

brain stem:0.78

corpus callosum/glia:0.79

pineal gland:0.36

peripheral nerve:-

spine:0.29

retina:-

eye:-

artery/aorta:1.72

vein:1.03

lymphnode:0.60

peripheral blood:-

spleen:1.48

thymus:0

bone marrow:-

adipose:1.29

bone:-

skin:-

RNA-seq

cerebrum:1.95

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:1.40

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:1.99

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:9.10

placenta:25.50

prostate:11.30

ovary:-

testis:-

heart:51.10

muscle:-

esophagus:-

stomach:21.20

intestine:-

colon:17

liver/hepato:-

lung:19.60

bladder:-

kidney:10.40

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:35.60

breast:9.30

salivary:-

GeneChip

uterus:5.58

placenta:4.90

prostate:5.16

ovary:4.95

testis:4.52

heart:5.67

muscle:5.18

esophagus:6.07

stomach:7.58

intestine:5.69

colon:6.62

liver/hepato:5.84

lung:7.52

bladder:-

kidney:5.53

pituitary:5.19

thyroid/parathyroid:7.52

adrenal gland:5.64

pancreas:5.77

breast:5.96

salivary:4.19

CAGE

uterus:0.69

placenta:0.92

prostate:1.59

ovary:0.86

testis:0.21

heart:0.95

muscle:0.40

esophagus:1.01

stomach:-

intestine:1.98

colon:2.10

liver/hepato:0.71

lung:1.95

bladder:1.71

kidney:0.92

pituitary:0.19

thyroid/parathyroid:1.79

adrenal gland:-

pancreas:1.59

breast:0.90

salivary:0

RNA-seq

uterus:-

placenta:-

prostate:3.54

ovary:0.67

testis:1.45

heart:1.09

muscle:0.78

esophagus:-

stomach:-

intestine:-

colon:2.03

liver/hepato:1.27

lung:3.73

bladder:-

kidney:2.01

pituitary:-

thyroid/parathyroid:2.56

adrenal gland:2.23

pancreas:-

breast:2.85

salivary:-

IDs

Refseq ID	NM_001200
Gene ID	650
Unigene ID	Hs.73853
Probe set ID	205290_s_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000125845
GTEx ID	ENSG00000125845

Orthologous Gene

Mouse[1]	NM_007553
Rat [0]

Chromosomal Region

20p12.3 [6,748,311 - 6,760,910]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR002405	Inhibin, alpha subunit
IPR015615	Transforming growth factor-beta-related

Gene Ontology (GO ID)

Biological Process

GO:0000187	activation of MAPK activity
GO:0060128	adrenocorticotropin hormone secreting cell differentiation
GO:0003181	atrioventricular valve morphogenesis
GO:0030509	BMP signaling pathway
GO:0003130	BMP signaling pathway involved in heart induction
GO:0030282	bone mineralization
GO:0001658	branching involved in ureteric bud morphogenesis
GO:0035051	cardiac cell differentiation
GO:0060317	cardiac epithelial to mesenchymal transition
GO:0055007	cardiac muscle cell differentiation
GO:0055008	cardiac muscle tissue morphogenesis
GO:0045165	cell fate commitment
GO:0007267	cell-cell signaling
GO:0071407	cellular response to organic cyclic substance
GO:0002062	chondrocyte differentiation
GO:0009790	embryonic development
GO:0035054	embryonic heart tube anterior/posterior pattern formation
GO:0003203	endocardial cushion morphogenesis
GO:0001837	epithelial to mesenchymal transition
GO:0030198	extracellular matrix organization
GO:0040007	growth
GO:0007507	heart development
GO:0001701	in utero embryonic development
GO:0006954	inflammatory response
GO:0048839	inner ear development
GO:0048762	mesenchymal cell differentiation
GO:0060485	mesenchyme development
GO:0032348	negative regulation of aldosterone biosynthetic process
GO:0051042	negative regulation of calcium-independent cell-cell adhesion
GO:0045786	negative regulation of cell cycle
GO:0008285	negative regulation of cell proliferation
GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway
GO:0010894	negative regulation of steroid biosynthetic process
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0045892	negative regulation of transcription, DNA-dependent
GO:0003308	negative regulation of Wnt receptor signaling pathway involved in heart development
GO:0090090	negative regulation of Wnt receptor signaling pathway through beta-catenin
GO:0007219	Notch signaling pathway
GO:0042475	odontogenesis of dentine-containing tooth
GO:0009887	organ morphogenesis
GO:0001649	osteoblast differentiation
GO:0060389	pathway-restricted SMAD protein phosphorylation
GO:0060039	pericardium development
GO:0043065	positive regulation of apoptosis
GO:0048711	positive regulation of astrocyte differentiation
GO:0030501	positive regulation of bone mineralization
GO:0030335	positive regulation of cell migration
GO:0001938	positive regulation of endothelial cell proliferation
GO:0010718	positive regulation of epithelial to mesenchymal transition
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0045600	positive regulation of fat cell differentiation
GO:0010628	positive regulation of gene expression
GO:0043410	positive regulation of MAPKKK cascade
GO:0045666	positive regulation of neuron differentiation
GO:0042482	positive regulation of odontogenesis
GO:0045778	positive regulation of ossification
GO:0045669	positive regulation of osteoblast differentiation
GO:0033690	positive regulation of osteoblast proliferation
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0010922	positive regulation of phosphatase activity
GO:0001934	positive regulation of protein amino acid phosphorylation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0045893	positive regulation of transcription, DNA-dependent
GO:0030177	positive regulation of Wnt receptor signaling pathway
GO:0060804	positive regulation of WNT receptor signaling pathway by BMP signaling pathway
GO:0006468	protein amino acid phosphorylation
GO:0031648	protein destabilization
GO:0006029	proteoglycan metabolic process
GO:0042487	regulation of odontogenesis of dentine-containing tooth
GO:0006355	regulation of transcription, DNA-dependent
GO:0001666	response to hypoxia
GO:0001501	skeletal system development
GO:0060395	SMAD protein signal transduction
GO:0021537	telencephalon development
GO:0021978	telencephalon regionalization
GO:0060129	thyroid stimulating hormone secreting cell differentiation

Cellular Component

GO:0009986	cell surface
GO:0005576	extracellular region
GO:0005615	extracellular space

Molecular Function

GO:0070700	BMP receptor binding
GO:0005125	cytokine activity
GO:0008083	growth factor activity
GO:0019211	phosphatase activator activity
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity
GO:0005102	receptor binding
GO:0004745	retinol dehydrogenase activity
GO:0046332	SMAD binding

bone morphogenetic protein 2

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function