PTEN induced putative kinase 1

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Synonym

PTEN-induced putative kinase protein 1, PINK1, FLJ27236, PARK6, PTEN induced putative kinase 1, BRPK

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:125.60

cerebellum:12.60

brain stem:-

corpus callosum/glia:29.20

pineal gland:-

peripheral nerve:153.40

spine:449.20

retina:237.30

eye:123.40

artery/aorta:-

vein:-

lymphnode:20.20

peripheral blood:72.90

spleen:18.90

thymus:-

bone marrow:19.70

adipose:40.30

bone:51.20

skin:110.40

GeneChip

cerebrum:9.02

cerebellum:8.64

brain stem:9.20

corpus callosum/glia:8.55

pineal gland:-

peripheral nerve:8.51

spine:8.73

retina:-

eye:-

artery/aorta:7.79

vein:8.27

lymphnode:7.05

peripheral blood:-

spleen:6.99

thymus:6.45

bone marrow:7.38

adipose:7.78

bone:-

skin:7.80

CAGE

cerebrum:4.65

cerebellum:-

brain stem:4.53

corpus callosum/glia:4.30

pineal gland:3.94

peripheral nerve:-

spine:4.23

retina:-

eye:-

artery/aorta:3.87

vein:3.26

lymphnode:2.96

peripheral blood:-

spleen:2.90

thymus:2.61

bone marrow:-

adipose:3.61

bone:-

skin:-

RNA-seq

cerebrum:5.89

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:4.91

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:5.47

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:72.90

placenta:83.80

prostate:67.60

ovary:74.50

testis:203.30

heart:76.60

muscle:221

esophagus:-

stomach:-

intestine:-

colon:25.40

liver/hepato:52.80

lung:92.90

bladder:-

kidney:93.60

pituitary:-

thyroid/parathyroid:-

adrenal gland:50.80

pancreas:80

breast:18.60

salivary:-

GeneChip

uterus:7.41

placenta:7.94

prostate:7.66

ovary:7.25

testis:9.22

heart:8.37

muscle:9.71

esophagus:8.32

stomach:7.41

intestine:7.82

colon:7.72

liver/hepato:8.14

lung:7.59

bladder:-

kidney:8.53

pituitary:7.76

thyroid/parathyroid:7.94

adrenal gland:8.61

pancreas:7.14

breast:7.85

salivary:8.30

CAGE

uterus:3.52

placenta:3.98

prostate:3.55

ovary:3.38

testis:4.78

heart:4.28

muscle:4.74

esophagus:3.85

stomach:-

intestine:3.49

colon:3.77

liver/hepato:4.23

lung:3.42

bladder:3.58

kidney:3.83

pituitary:3.20

thyroid/parathyroid:3.98

adrenal gland:-

pancreas:3.75

breast:3.81

salivary:3.78

RNA-seq

uterus:-

placenta:-

prostate:5.04

ovary:4.58

testis:5.90

heart:6.02

muscle:6.51

esophagus:-

stomach:-

intestine:-

colon:5.17

liver/hepato:5.21

lung:4.45

bladder:-

kidney:5.40

pituitary:-

thyroid/parathyroid:5.56

adrenal gland:4.39

pancreas:-

breast:5.19

salivary:-

IDs

Refseq ID	NM_032409
Gene ID	65018
Unigene ID	Hs.389171
Probe set ID	209019_s_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000158828
GTEx ID	ENSG00000158828

Orthologous Gene

Mouse[1]	NM_026880
Rat [0]

Chromosomal Region

1p36.12 [20,959,948 - 20,978,004]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR000719	Protein kinase, catalytic domain
IPR011009	Protein kinase-like domain
IPR002290	Serine/threonine-protein kinase domain
IPR017442	Serine/threonine-protein kinase-like domain
IPR001245	Tyrosine-protein kinase, catalytic domain
IPR020635	Tyrosine-protein kinase, subgroup, catalytic domain

Gene Ontology (GO ID)

Biological Process

GO:0008219	cell death
GO:0000422	mitochondrion degradation
GO:0043524	negative regulation of neuron apoptosis
GO:0018105	peptidyl-serine phosphorylation
GO:0033603	positive regulation of dopamine secretion
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0090200	positive regulation of release of cytochrome c from mitochondria
GO:0032226	positive regulation of synaptic transmission, dopaminergic
GO:0006468	protein amino acid phosphorylation
GO:0007243	protein kinase cascade
GO:0043254	regulation of protein complex assembly
GO:0031396	regulation of protein ubiquitination
GO:0006950	response to stress

Cellular Component

GO:0005829	cytosol
GO:0016021	integral to membrane
GO:0005741	mitochondrial outer membrane
GO:0005739	mitochondrion

Molecular Function

GO:0005524	ATP binding
GO:0010857	calcium-dependent protein kinase activity
GO:0016301	kinase activity
GO:0000287	magnesium ion binding
GO:0005515	protein binding
GO:0004674	protein serine/threonine kinase activity
GO:0055131	RING finger domain binding
GO:0031625	ubiquitin protein ligase binding

PTEN induced putative kinase 1

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function