WNK lysine deficient protein kinase 2

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Synonym

Serine/threonine-protein kinase WNK2, NY-CO-43, KIAA1760, WNK lysine deficient protein kinase 2, P/OKcl.13, Protein kinase, lysine-deficient 2, SDCCAG43, WNK2, serologically defined colon cancer antigen 43, PRKWNK2, Protein kinase with no lysine 2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip nodata
CAGE cerebrum:0.01 cerebellum:- brain stem:0 corpus callosum/glia:0 pineal gland:0 peripheral nerve:- spine:0 retina:- eye:- artery/aorta:0 vein:0 lymphnode:0.03 peripheral blood:- spleen:0 thymus:0.06 bone marrow:- adipose:0 bone:- skin:-
RNA-seq cerebrum:2.54 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.33 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.27 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip nodata
CAGE uterus:0 placenta:0 prostate:0 ovary:0 testis:0 heart:0 muscle:0 esophagus:0 stomach:- intestine:1.74 colon:0.80     liver/hepato:0    lung:0 bladder:0 kidney:0 pituitary:0 thyroid/parathyroid:0 adrenal gland:- pancreas:0 breast:0 salivary:0
RNA-seq uterus:- placenta:- prostate:1.62 ovary:1.19 testis:2.39 heart:3.80 muscle:2.95 esophagus:- stomach:- intestine:- colon:2.70     liver/hepato:0.10        lung:0.41    bladder:- kidney:0.19 pituitary:- thyroid/parathyroid:1.49 adrenal gland:1.29 pancreas:- breast:1.45 salivary:-

Gene Information

IDs

Refseq ID NM_006648
Gene ID 65268
Unigene ID -
Probe set ID -
Ensembl ID ENSG00000165238
GTEx ID ENSG00000165238

Orthologous Gene

Mouse[1]  NM_029361
Rat [0]  

Chromosomal Region

9q22.31  [95,947,198  -  96,082,854]

Gene Family (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

9610721
11214970
11280764
11498583
11571656
12477932
14702039
15489334
16713569
17474147
17578925
17667937
18593598
18768590
19001526
19724895
19851296
20198315
20379614
20525693
20936779
21733846
21988832
23035050
23387299
23797875
23838290

Gene Ontology  (GO ID)

Biological Process

GO:0008285  negative regulation of cell proliferation
GO:0070373  negative regulation of ERK1 and ERK2 cascade
GO:0046777  protein amino acid autophosphorylation
GO:0006468  protein amino acid phosphorylation
GO:0007243  protein kinase cascade

Cellular Component

GO:0005737  cytoplasm
GO:0005886  plasma membrane

Molecular Function

GO:0005524  ATP binding
GO:0004674  protein serine/threonine kinase activity