solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12

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Synonym

FLJ38727, Sodium- and chloride-dependent betaine transporter, SLC6A12, Na+/Cl-betaine/GABA transporter, BGT-1, BGT1

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:47.40 cerebellum:75.60 brain stem:- corpus callosum/glia:87.50 pineal gland:- peripheral nerve:- spine:- retina:- eye:5.90 artery/aorta:- vein:- lymphnode:- peripheral blood:36.40 spleen:- thymus:12.90 bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:6.06 cerebellum:5.37 brain stem:6.14 corpus callosum/glia:5.59 pineal gland:- peripheral nerve:5.20 spine:5.63 retina:- eye:- artery/aorta:4.84 vein:4.71 lymphnode:4.71 peripheral blood:- spleen:4.62 thymus:4.37 bone marrow:4.89 adipose:4.96 bone:- skin:4.92
CAGE cerebrum:1.79 cerebellum:- brain stem:2.28 corpus callosum/glia:2.08 pineal gland:1.03 peripheral nerve:- spine:1.22 retina:- eye:- artery/aorta:0.34 vein:0.18 lymphnode:0.03 peripheral blood:- spleen:0.88 thymus:0.06 bone marrow:- adipose:0.96 bone:- skin:-
RNA-seq cerebrum:2.12 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:14.60 prostate:- ovary:- testis:8.70 heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:31.70        lung:4.90    bladder:- kidney:166.40 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:4.61 placenta:4.92 prostate:4.70 ovary:4.86 testis:5.12 heart:4.82 muscle:5.12 esophagus:4.71 stomach:4.77 intestine:4.87 colon:5.16 liver/hepato:7.08 lung:4.87 bladder:- kidney:7.80 pituitary:5.12 thyroid/parathyroid:5.06 adrenal gland:5.27 pancreas:5.29 breast:4.58 salivary:4.89
CAGE uterus:0.04 placenta:0.81 prostate:0 ovary:0.32 testis:0.10 heart:0.07 muscle:0.05 esophagus:0 stomach:- intestine:1.10 colon:0.51     liver/hepato:3.00    lung:0.84 bladder:0.09 kidney:3.42 pituitary:0.24 thyroid/parathyroid:2.01 adrenal gland:- pancreas:0 breast:0.55 salivary:0.36
RNA-seq uterus:- placenta:- prostate:0 ovary:0.34 testis:0 heart:0.08 muscle:0 esophagus:- stomach:- intestine:- colon:0     liver/hepato:1.34        lung:0    bladder:- kidney:3.97 pituitary:- thyroid/parathyroid:0.56 adrenal gland:0.23 pancreas:- breast:0.10 salivary:-

Gene Information

IDs

Refseq ID NM_001122848
Gene ID 6539
Unigene ID Hs.437174
Probe set ID 206058_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000111181
GTEx ID ENSG00000111181

Orthologous Gene

Mouse[1]  NM_133661
Rat [0]  

Chromosomal Region

12p13.33  [299,243  -  323,736]

Gene Family (Interpro ID)

IPR000175  Sodium:neurotransmitter symporter
IPR002983  Sodium:neurotransmitter symporter, betaine

Link to Pubmed  (Pubmed ID)

7589472
7861179
10228153
12111824
12477932
14702039
15123239
16198020
16344560
18195088
19086053
19204726
20383146
20424473
20597903
21367462
22405821
23378610

Gene Ontology  (GO ID)

Biological Process

GO:0006865  amino acid transport
GO:0071474  cellular hyperosmotic response
GO:0009992  cellular water homeostasis
GO:0006811  ion transport
GO:0007269  neurotransmitter secretion
GO:0010033  response to organic substance
GO:0007268  synaptic transmission
GO:0055085  transmembrane transport
GO:0006810  transport

Cellular Component

GO:0016021  integral to membrane
GO:0005887  integral to plasma membrane
GO:0005886  plasma membrane

Molecular Function

GO:0005332  gamma-aminobutyric acid:sodium symporter activity
GO:0005328  neurotransmitter:sodium symporter activity