bone morphogenetic protein 6

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Synonym

Bone morphogenetic protein 6 precursor, VGR, BMP 6, VGR1, BMP-6, BMP6, bone morphogenetic protein 6, vegetal related growth factor (TGFB-related)

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:4.70 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:23.50 artery/aorta:89.90 vein:199.90 lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:12.80 skin:14.40
GeneChip cerebrum:5.29 cerebellum:5.26 brain stem:5.29 corpus callosum/glia:5.26 pineal gland:- peripheral nerve:5.43 spine:5.41 retina:- eye:- artery/aorta:5.53 vein:6.24 lymphnode:5.33 peripheral blood:- spleen:5.22 thymus:4.97 bone marrow:5.33 adipose:6 bone:- skin:5.54
CAGE cerebrum:1.12 cerebellum:- brain stem:1.15 corpus callosum/glia:1.04 pineal gland:1.18 peripheral nerve:- spine:1.05 retina:- eye:- artery/aorta:2.30 vein:1.57 lymphnode:1.42 peripheral blood:- spleen:1.15 thymus:0.18 bone marrow:- adipose:3.06 bone:- skin:-
RNA-seq cerebrum:1.24 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.54 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:4.62 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:18.20 placenta:72.90 prostate:11.30 ovary:74.50 testis:4.30 heart:- muscle:- esophagus:- stomach:- intestine:32.40 colon:8.50     liver/hepato:31.70        lung:19.60    bladder:- kidney:10.40 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:5.22 placenta:7.14 prostate:4.98 ovary:5.85 testis:5.22 heart:5.42 muscle:5.54 esophagus:5.20 stomach:5.49 intestine:5.69 colon:5.37 liver/hepato:5.20 lung:5.49 bladder:- kidney:6.18 pituitary:5.71 thyroid/parathyroid:5.14 adrenal gland:5.25 pancreas:5.67 breast:5.34 salivary:5.44
CAGE uterus:1.53 placenta:2.65 prostate:1.49 ovary:1.73 testis:1.22 heart:1.60 muscle:2.06 esophagus:1.31 stomach:- intestine:1.44 colon:1.61     liver/hepato:0.71    lung:2.09 bladder:1.45 kidney:1.24 pituitary:1.24 thyroid/parathyroid:0.82 adrenal gland:- pancreas:0.58 breast:2.64 salivary:1.39
RNA-seq uterus:- placenta:- prostate:1.16 ovary:2.72 testis:2.45 heart:0.93 muscle:0.89 esophagus:- stomach:- intestine:- colon:2.41     liver/hepato:1.91        lung:3.49    bladder:- kidney:2.10 pituitary:- thyroid/parathyroid:1.01 adrenal gland:1.78 pancreas:- breast:2.51 salivary:-

Gene Information

IDs

Refseq ID NM_001718
Gene ID 654
Unigene ID Hs.285671
Probe set ID 206176_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000153162
GTEx ID ENSG00000153162

Orthologous Gene

Mouse[1]  NM_007556
Rat[1]  NM_007556

Chromosomal Region

6p24.3  [7,726,332  -  7,881,655]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

1427904
1453478
2263636
7605353
7811286
8089189
9116752
9331107
9417921
9435314
9512655
10504300
10582704
11401330
11865031
12140680
12477932
12897139
13130469
14558086
14574404
14623234
14660436
15186723
15516325
15548695
15784727
15861517
15877825
16527843
16547600
16604289
16886151
17238135
17244894
17262821
17574840
17575215
17577985
17879955
17899540
17924656
18070108
18187665
18308844
18326817
18349123
18391951
18436533
18632632
18683889
18688853
18805502
18931653
18949431
19075223
19093115
19245827
19252488
19266077
19308091
19366699
19539911
19543302
19694819
19718049
19765379
20016212
20048150
20379614
20401668
20460105
20530805
20546612
20567515
20573596
20587610
20605837
20634891
20734064
20844121
20881960
21136273
21622652
21898381
21963094
22086350
22305102
22364398
22419666
22641693
22792339
23049088
23563607
23674072
23799295
24012720
24185914
24518599

Gene Ontology  (GO ID)

Biological Process

GO:0030509  BMP signaling pathway
GO:0051216  cartilage development
GO:0001958  endochondral ossification
GO:0001654  eye development
GO:0040007  growth
GO:0006955  immune response
GO:0006954  inflammatory response
GO:0001822  kidney development
GO:0030539  male genitalia development
GO:0001649  osteoblast differentiation
GO:0003323  pancreatic B cell development
GO:0032349  positive regulation of aldosterone biosynthetic process
GO:0030501  positive regulation of bone mineralization
GO:0045603  positive regulation of endothelial cell differentiation
GO:0001938  positive regulation of endothelial cell proliferation
GO:0050679  positive regulation of epithelial cell proliferation
GO:0045666  positive regulation of neuron differentiation
GO:0045669  positive regulation of osteoblast differentiation
GO:0010862  positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0050714  positive regulation of protein secretion
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0051384  response to glucocorticoid stimulus
GO:0032526  response to retinoic acid
GO:0001501  skeletal system development
GO:0060395  SMAD protein signal transduction

Cellular Component

GO:0005737  cytoplasm
GO:0005615  extracellular space
GO:0031988  membrane-bounded vesicle

Molecular Function

GO:0070700  BMP receptor binding
GO:0005125  cytokine activity
GO:0008083  growth factor activity
GO:0046982  protein heterodimerization activity