solute carrier family 9 (sodium/hydrogen exchanger), member 1

Synonym

Na(+)/H(+) antiporter, amiloride-sensitive, Na(+)/H(+) exchanger 1, FLJ42224, APNH, NHE-1, Solute carrier family 9 member 1, Na+/H+, SLC9A1, NHE1, Sodium/hydrogen exchanger 1, APNH1

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:43.90

cerebellum:63

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:118.60

eye:52.90

artery/aorta:30

vein:199.90

lymphnode:-

peripheral blood:-

spleen:56.70

thymus:25.80

bone marrow:78.70

adipose:-

bone:12.80

skin:52.80

GeneChip

cerebrum:7.43

cerebellum:7.45

brain stem:7.32

corpus callosum/glia:6.91

pineal gland:-

peripheral nerve:7.18

spine:7.13

retina:-

eye:-

artery/aorta:7.39

vein:7.40

lymphnode:7.44

peripheral blood:-

spleen:7.62

thymus:7.03

bone marrow:7.19

adipose:7.33

bone:-

skin:7.31

CAGE

cerebrum:3.28

cerebellum:-

brain stem:3.12

corpus callosum/glia:2.96

pineal gland:3.15

peripheral nerve:-

spine:2.77

retina:-

eye:-

artery/aorta:3.50

vein:3.02

lymphnode:3.22

peripheral blood:-

spleen:3.63

thymus:2.88

bone marrow:-

adipose:2.72

bone:-

skin:-

RNA-seq

cerebrum:2.59

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:2.49

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:2.76

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:18.20

placenta:116.60

prostate:78.90

ovary:37.30

testis:51.90

heart:-

muscle:-

esophagus:-

stomach:42.50

intestine:-

colon:110.20

liver/hepato:42.20

lung:48.90

bladder:-

kidney:10.40

pituitary:-

thyroid/parathyroid:491.20

adrenal gland:-

pancreas:17.80

breast:74.30

salivary:-

GeneChip

uterus:7.30

placenta:8.65

prostate:7.31

ovary:7.06

testis:6.75

heart:7.36

muscle:7.16

esophagus:7.61

stomach:8.27

intestine:7.52

colon:8.03

liver/hepato:6.97

lung:7.77

bladder:-

kidney:7.29

pituitary:7.22

thyroid/parathyroid:7.48

adrenal gland:7.35

pancreas:7.09

breast:7.72

salivary:9.62

CAGE

uterus:3.03

placenta:4.96

prostate:3.52

ovary:3.15

testis:2.46

heart:3.11

muscle:2.52

esophagus:3.15

stomach:-

intestine:4.45

colon:3.87

liver/hepato:1.76

lung:3.79

bladder:3.39

kidney:3.26

pituitary:3.10

thyroid/parathyroid:3.04

adrenal gland:-

pancreas:2.90

breast:3.02

salivary:5.02

RNA-seq

uterus:-

placenta:-

prostate:3.03

ovary:2.94

testis:2.93

heart:1.80

muscle:1.34

esophagus:-

stomach:-

intestine:-

colon:2.79

liver/hepato:0.61

lung:3.05

bladder:-

kidney:2.63

pituitary:-

thyroid/parathyroid:2.54

adrenal gland:2.75

pancreas:-

breast:2.67

salivary:-

IDs

Refseq ID	NM_003047
Gene ID	6548
Unigene ID	Hs.469116
Probe set ID	209453_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000090020
GTEx ID	ENSG00000090020

Orthologous Gene

Mouse[1]	NM_016981
Rat [0]

Chromosomal Region

1p36.11 [27,425,306 - 27,493,472]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR006153	Cation/H+ exchanger
IPR001970	Na+/H+ exchanger, isoform 1 (NHE1)
IPR004709	Na+/H+ exchanger, subfamily

Gene Ontology (GO ID)

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0055007	cardiac muscle cell differentiation
GO:0016049	cell growth
GO:0071468	cellular response to acidity
GO:0030203	glycosaminoglycan metabolic process
GO:0030214	hyaluronan catabolic process
GO:0030212	hyaluronan metabolic process
GO:0006811	ion transport
GO:0070997	neuron death
GO:0045760	positive regulation of action potential
GO:0030307	positive regulation of cell growth
GO:0010740	positive regulation of protein kinase cascade
GO:0051259	protein oligomerization
GO:0051453	regulation of intracellular pH
GO:0006885	regulation of pH
GO:0051930	regulation of sensory perception of pain
GO:0002026	regulation of the force of heart contraction
GO:0001101	response to acid
GO:0010447	response to acidity
GO:0042493	response to drug
GO:0014070	response to organic cyclic substance
GO:0071436	sodium ion export
GO:0055085	transmembrane transport

Cellular Component

GO:0016323	basolateral plasma membrane
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral to membrane
GO:0045121	membrane raft
GO:0005739	mitochondrion
GO:0005886	plasma membrane

Molecular Function

GO:0048306	calcium-dependent protein binding
GO:0005516	calmodulin binding
GO:0005515	protein binding
GO:0015385	sodium:hydrogen antiporter activity
GO:0015299	solute:hydrogen antiporter activity

solute carrier family 9 (sodium/hydrogen exchanger), member 1

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function