solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1

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Synonym

SLC11A1, NRAMP1, Natural resistance-associated macrophage protein 1, NRAMP 1, NRAMP, LSH

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:8.30

cerebellum:50.40

brain stem:-

corpus callosum/glia:58.30

pineal gland:-

peripheral nerve:-

spine:-

retina:118.60

eye:41.10

artery/aorta:-

vein:-

lymphnode:20.20

peripheral blood:364.40

spleen:132.30

thymus:12.90

bone marrow:39.40

adipose:40.30

bone:51.20

skin:4.80

GeneChip

cerebrum:4.21

cerebellum:4.22

brain stem:4.35

corpus callosum/glia:4.15

pineal gland:-

peripheral nerve:4.01

spine:4.02

retina:-

eye:-

artery/aorta:4.03

vein:4.40

lymphnode:4.06

peripheral blood:-

spleen:4.03

thymus:4.09

bone marrow:4.56

adipose:4.25

bone:-

skin:4.58

CAGE

cerebrum:2.61

cerebellum:-

brain stem:3.22

corpus callosum/glia:2.70

pineal gland:2.94

peripheral nerve:-

spine:4.13

retina:-

eye:-

artery/aorta:2.62

vein:1.53

lymphnode:2.55

peripheral blood:-

spleen:3.81

thymus:0.71

bone marrow:-

adipose:3.72

bone:-

skin:-

RNA-seq

cerebrum:1.51

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:1.46

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:2.67

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:36.50

placenta:40.10

prostate:-

ovary:-

testis:4.30

heart:-

muscle:-

esophagus:-

stomach:-

intestine:-

colon:33.90

liver/hepato:-

lung:127.10

bladder:125.60

kidney:-

pituitary:-

thyroid/parathyroid:-

adrenal gland:50.80

pancreas:-

breast:9.30

salivary:-

GeneChip

uterus:4.02

placenta:4.06

prostate:3.97

ovary:4.08

testis:4.04

heart:4.45

muscle:4.53

esophagus:4.07

stomach:4.08

intestine:4.19

colon:4.39

liver/hepato:4.10

lung:5.85

bladder:-

kidney:4.18

pituitary:3.99

thyroid/parathyroid:3.77

adrenal gland:4.13

pancreas:4.34

breast:3.85

salivary:4.21

CAGE

uterus:1.10

placenta:2.20

prostate:1.42

ovary:2.18

testis:1.38

heart:2.22

muscle:1.97

esophagus:1.62

stomach:-

intestine:0.99

colon:0.82

liver/hepato:1.79

lung:4.72

bladder:3.07

kidney:2.07

pituitary:1.96

thyroid/parathyroid:1.48

adrenal gland:-

pancreas:1.98

breast:1.92

salivary:0.83

RNA-seq

uterus:-

placenta:-

prostate:0.83

ovary:0.41

testis:0.49

heart:0.59

muscle:0.19

esophagus:-

stomach:-

intestine:-

colon:0.64

liver/hepato:0.96

lung:3.56

bladder:-

kidney:0.92

pituitary:-

thyroid/parathyroid:0.75

adrenal gland:0.67

pancreas:-

breast:0.45

salivary:-

IDs

Refseq ID	NM_000578
Gene ID	6556
Unigene ID	Hs.591607
Probe set ID	217507_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000018280
GTEx ID	ENSG00000018280

Orthologous Gene

Mouse[1]	NM_013612
Rat[1]	NM_001031658

Chromosomal Region

2q35 [219,246,752 - 219,261,617]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR001046

Natural resistance-associated macrophage protein

Gene Ontology (GO ID)

Biological Process

GO:0032147	activation of protein kinase activity
GO:0048002	antigen processing and presentation of peptide antigen
GO:0070574	cadmium ion transmembrane transport
GO:0006876	cellular cadmium ion homeostasis
GO:0006879	cellular iron ion homeostasis
GO:0042742	defense response to bacterium
GO:0050829	defense response to Gram-negative bacterium
GO:0042832	defense response to protozoan
GO:0070839	divalent metal ion export
GO:0006954	inflammatory response
GO:0051701	interaction with host
GO:0032623	interleukin-2 production
GO:0032632	interleukin-3 production
GO:0055072	iron ion homeostasis
GO:0006826	iron ion transport
GO:0043091	L-arginine import
GO:0042116	macrophage activation
GO:0006828	manganese ion transport
GO:0045342	MHC class II biosynthetic process
GO:0048255	mRNA stabilization
GO:0060586	multicellular organismal iron ion homeostasis
GO:0001818	negative regulation of cytokine production
GO:0015707	nitrite transport
GO:0006909	phagocytosis
GO:0001819	positive regulation of cytokine production
GO:0002606	positive regulation of dendritic cell antigen processing and presentation
GO:0010628	positive regulation of gene expression
GO:0032729	positive regulation of interferon-gamma production
GO:0050766	positive regulation of phagocytosis
GO:0002827	positive regulation of T-helper 1 type immune response
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0000060	protein import into nucleus, translocation
GO:0045730	respiratory burst
GO:0009617	response to bacterium
GO:0034341	response to interferon-gamma
GO:0032496	response to lipopolysaccharide
GO:0002369	T cell cytokine production
GO:0002309	T cell proliferation during immune response
GO:0055085	transmembrane transport
GO:0007035	vacuolar acidification
GO:0042060	wound healing

Cellular Component

GO:0009279	cell outer membrane
GO:0005887	integral to plasma membrane
GO:0005770	late endosome
GO:0031902	late endosome membrane
GO:0005764	lysosome
GO:0030670	phagocytic vesicle membrane
GO:0005886	plasma membrane
GO:0070821	tertiary granule membrane

Molecular Function

GO:0005384	manganese ion transmembrane transporter activity
GO:0051139	metal ion:hydrogen antiporter activity
GO:0042803	protein homodimerization activity
GO:0046915	transition metal ion transmembrane transporter activity

solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function