bone morphogenetic protein receptor, type IB

 jump to detail

Synonym

BMPR 1B, BMPR-1B, BMPR Ib, BMP type Ib receptor, BMPR1b, CDw293 antigen, BMPRIb, BMPR IB, BMPR-1b, BMP type-1B receptor, BMPR-Ib, bone morphogenetic protein receptor, type IB, BMPR 1b, CDw293, BMP type IB receptor, BMP type-Ib receptor, ALK6, BMP type-IB receptor, BMP type-1b receptor, ALK-6, BMP type 1b receptor, BMP type 1B receptor, BMPR1B, BMPRIB

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:4.70 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:30.70 spine:- retina:118.60 eye:5.90 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:4 cerebellum:3.79 brain stem:4.08 corpus callosum/glia:3.91 pineal gland:- peripheral nerve:3.82 spine:3.77 retina:- eye:- artery/aorta:3.83 vein:3.89 lymphnode:3.56 peripheral blood:- spleen:3.38 thymus:3.62 bone marrow:3.69 adipose:3.93 bone:- skin:4.04
CAGE cerebrum:3.01 cerebellum:- brain stem:2.48 corpus callosum/glia:2.65 pineal gland:1.12 peripheral nerve:- spine:3.18 retina:- eye:- artery/aorta:2.41 vein:1.53 lymphnode:0.06 peripheral blood:- spleen:0.17 thymus:3.07 bone marrow:- adipose:0.36 bone:- skin:-
RNA-seq cerebrum:1.94 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.45 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.28 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:3.60 prostate:45.10 ovary:- testis:4.30 heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:9.80    bladder:- kidney:20.80 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:3.54 placenta:3.74 prostate:4.39 ovary:3.56 testis:3.69 heart:3.99 muscle:4.29 esophagus:3.52 stomach:3.61 intestine:3.78 colon:3.76 liver/hepato:3.83 lung:3.47 bladder:- kidney:3.98 pituitary:3.68 thyroid/parathyroid:3.35 adrenal gland:3.55 pancreas:3.99 breast:3.49 salivary:3.58
CAGE uterus:1.62 placenta:0.43 prostate:2.27 ovary:2.19 testis:1.71 heart:0.70 muscle:1.37 esophagus:1.54 stomach:- intestine:0 colon:0.29     liver/hepato:0.26    lung:1.31 bladder:0.91 kidney:1.80 pituitary:1.02 thyroid/parathyroid:0.45 adrenal gland:- pancreas:0.58 breast:1.36 salivary:0.36
RNA-seq uterus:- placenta:- prostate:0.48 ovary:2.62 testis:2.35 heart:0.57 muscle:0.00 esophagus:- stomach:- intestine:- colon:0.84     liver/hepato:0.06        lung:0.75    bladder:- kidney:0.36 pituitary:- thyroid/parathyroid:0.53 adrenal gland:0.12 pancreas:- breast:0.00 salivary:-

Gene Information

IDs

Refseq ID NM_001203
Gene ID 658
Unigene ID Hs.598475
Probe set ID 210523_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000138696
GTEx ID ENSG00000138696

Orthologous Gene

Mouse[1]  NM_007560
Rat[1]  NM_001024259

Chromosomal Region

4q22.3  [95,679,119  -  96,079,599]

Gene Family (Interpro ID)

IPR000333  Activin type II receptor
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

7791754
7811286
8006002
8140412
8605097
8702914
8707881
9178898
9436979
9525338
9730621
9872992
9950587
10051328
10504300
10712517
10850425
11266516
11279102
11282024
11312159
11401330
11420127
11483516
11781009
12065756
12135884
12419820
12477932
12857866
14523231
14576167
15064755
15192043
15235019
15489334
15611116
15621726
15761153
15775969
15805157
15897891
16014698
16436528
17001689
17203235
17356069
17363346
17381068
17624341
18184661
18292470
18436533
18619554
18758450
18773965
19135982
19451094
19453261
19513897
19738052
19758997
19782107
19953087
20201926
20467438
20587070
20634891
20673479
20732626
20734064
21152263
21556765
21791611
21832049
22293501
22294741
22374147
22384028
22971142
24008158
24021264
24100446
24850914

Gene Ontology  (GO ID)

Biological Process

GO:0030509  BMP signaling pathway
GO:0001502  cartilage condensation
GO:0009953  dorsal/ventral pattern formation
GO:0001654  eye development
GO:0006954  inflammatory response
GO:0035108  limb morphogenesis
GO:0001550  ovarian cumulus expansion
GO:0042698  ovulation cycle
GO:0030501  positive regulation of bone mineralization
GO:0045597  positive regulation of cell differentiation
GO:0045669  positive regulation of osteoblast differentiation
GO:0006468  protein amino acid phosphorylation
GO:0060041  retina development in camera-type eye
GO:0031290  retinal ganglion cell axon guidance
GO:0001501  skeletal system development

Cellular Component

GO:0005887  integral to plasma membrane
GO:0005886  plasma membrane
GO:0043235  receptor complex

Molecular Function

GO:0005524  ATP binding
GO:0046872  metal ion binding
GO:0005515  protein binding
GO:0004674  protein serine/threonine kinase activity
GO:0004702  receptor signaling protein serine/threonine kinase activity
GO:0046332  SMAD binding
GO:0005025  transforming growth factor beta receptor activity, type I
GO:0004675  transmembrane receptor protein serine/threonine kinase activity