bone morphogenetic protein receptor, type II (serine/threonine kinase)

Synonym

BMR-2, BMPR 2, BMP type 2 receptor, BMP type II receptor, BMP type2 receptor, BRK-3, BMPR2, BMPRII, BMPR3, BMR 2, BMPR-II, BMPR II, BMR2, BMP type-2 receptor, BMPR-2, Bone morphogenetic protein receptor type II, BMP type-II receptor, BMP typeII receptor, PPH1, T-ALK

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:125.60

cerebellum:50.40

brain stem:-

corpus callosum/glia:87.50

pineal gland:148.30

peripheral nerve:122.70

spine:224.60

retina:237.30

eye:123.40

artery/aorta:329.70

vein:66.60

lymphnode:20.20

peripheral blood:54.70

spleen:18.90

thymus:-

bone marrow:118.10

adipose:-

bone:102.40

skin:134.40

GeneChip

cerebrum:5.73

cerebellum:5.42

brain stem:5.82

corpus callosum/glia:5.08

pineal gland:-

peripheral nerve:6.18

spine:5.22

retina:-

eye:-

artery/aorta:5.90

vein:5.95

lymphnode:5.46

peripheral blood:-

spleen:6.07

thymus:4.89

bone marrow:4.68

adipose:5.73

bone:-

skin:5.41

CAGE

cerebrum:3.70

cerebellum:-

brain stem:3.63

corpus callosum/glia:3.37

pineal gland:4.17

peripheral nerve:-

spine:3.31

retina:-

eye:-

artery/aorta:3.90

vein:3.52

lymphnode:2.95

peripheral blood:-

spleen:3.66

thymus:2.90

bone marrow:-

adipose:4.10

bone:-

skin:-

RNA-seq

cerebrum:4.10

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:3.62

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:4.07

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:100.20

placenta:160.30

prostate:112.60

ovary:74.50

testis:38.90

heart:51.10

muscle:-

esophagus:342.80

stomach:127.50

intestine:129.60

colon:296.80

liver/hepato:105.60

lung:112.40

bladder:-

kidney:52

pituitary:-

thyroid/parathyroid:327.50

adrenal gland:152.40

pancreas:142.30

breast:185.90

salivary:-

GeneChip

uterus:6.04

placenta:5.89

prostate:6.30

ovary:6.06

testis:5.52

heart:6.04

muscle:5.19

esophagus:5.68

stomach:5.80

intestine:5.43

colon:4.90

liver/hepato:5.61

lung:6.94

bladder:-

kidney:5.60

pituitary:5.23

thyroid/parathyroid:5.84

adrenal gland:6.65

pancreas:5.75

breast:6

salivary:5.47

CAGE

uterus:4.03

placenta:4.01

prostate:4.00

ovary:4.08

testis:3.59

heart:3.96

muscle:3.23

esophagus:3.83

stomach:-

intestine:3.69

colon:3.33

liver/hepato:3.49

lung:4.53

bladder:4.03

kidney:3.41

pituitary:3.56

thyroid/parathyroid:3.68

adrenal gland:-

pancreas:2.48

breast:3.78

salivary:3.09

RNA-seq

uterus:-

placenta:-

prostate:3.74

ovary:3.98

testis:3.70

heart:3.85

muscle:2.99

esophagus:-

stomach:-

intestine:-

colon:3.97

liver/hepato:2.06

lung:5.42

bladder:-

kidney:3.59

pituitary:-

thyroid/parathyroid:3.26

adrenal gland:3.51

pancreas:-

breast:3.87

salivary:-

IDs

Refseq ID	NM_001204
Gene ID	659
Unigene ID	Hs.471119
Probe set ID	209920_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000204217
GTEx ID	ENSG00000204217

Orthologous Gene

Mouse[2]	NM_007561
Rat [0]

Chromosomal Region

2q33.1 [203,241,659 - 203,432,474]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR000719	Protein kinase, catalytic domain
IPR011009	Protein kinase-like domain
IPR002290	Serine/threonine-protein kinase domain
IPR017442	Serine/threonine-protein kinase-like domain
IPR001245	Tyrosine-protein kinase, catalytic domain
IPR020635	Tyrosine-protein kinase, subgroup, catalytic domain

Gene Ontology (GO ID)

Biological Process

GO:0009952	anterior/posterior pattern formation
GO:0060840	artery development
GO:0001974	blood vessel remodeling
GO:0030509	BMP signaling pathway
GO:0009267	cellular response to starvation
GO:0048286	lung alveolus development
GO:0001946	lymphangiogenesis
GO:0060836	lymphatic endothelial cell differentiation
GO:0001707	mesoderm formation
GO:0030308	negative regulation of cell growth
GO:0003085	negative regulation of systemic arterial blood pressure
GO:0045906	negative regulation of vasoconstriction
GO:0030513	positive regulation of BMP signaling pathway
GO:0030501	positive regulation of bone mineralization
GO:0010595	positive regulation of endothelial cell migration
GO:0001938	positive regulation of endothelial cell proliferation
GO:0010634	positive regulation of epithelial cell migration
GO:0045669	positive regulation of osteoblast differentiation
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0042127	regulation of cell proliferation
GO:0014916	regulation of lung blood pressure
GO:0006366	transcription from RNA polymerase II promoter
GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0048010	vascular endothelial growth factor receptor signaling pathway
GO:0060841	venous blood vessel development

Cellular Component

GO:0005901	caveola
GO:0009986	cell surface
GO:0005887	integral to plasma membrane
GO:0005886	plasma membrane

Molecular Function

GO:0016362	activin receptor activity, type II
GO:0005524	ATP binding
GO:0046872	metal ion binding
GO:0005515	protein binding
GO:0005024	transforming growth factor beta receptor activity

bone morphogenetic protein receptor, type II (serine/threonine kinase)

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function