snail homolog 2 (Drosophila)

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Synonym

Zinc finger protein SLUG, WS2D, SLUGH, SLUG, SLUGH1, MGC10182, SNAI2, snail homolog 2 (Drosophila), Neural crest transcription factor Slug, Snail homolog 2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:3.85 cerebellum:4.75 brain stem:3.71 corpus callosum/glia:4 pineal gland:- peripheral nerve:5.15 spine:4.13 retina:- eye:- artery/aorta:6.07 vein:5.39 lymphnode:5.80 peripheral blood:- spleen:6.73 thymus:5.24 bone marrow:4.53 adipose:6.84 bone:- skin:7.53
CAGE cerebrum:1.50 cerebellum:- brain stem:1.38 corpus callosum/glia:1.72 pineal gland:1.87 peripheral nerve:- spine:1.96 retina:- eye:- artery/aorta:3.55 vein:3.28 lymphnode:3.24 peripheral blood:- spleen:3.21 thymus:2.33 bone marrow:- adipose:3.50 bone:- skin:-
RNA-seq cerebrum:0.76 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.61 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.86 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:8.88 placenta:6.47 prostate:6.97 ovary:7.82 testis:5.03 heart:6 muscle:4.30 esophagus:6.16 stomach:6.12 intestine:6.02 colon:6.31 liver/hepato:5.88 lung:5.10 bladder:- kidney:5.73 pituitary:3.90 thyroid/parathyroid:5.32 adrenal gland:7.04 pancreas:4.93 breast:7.83 salivary:5.88
CAGE uterus:4.63 placenta:3.27 prostate:4.45 ovary:4.16 testis:2.93 heart:3.27 muscle:2.38 esophagus:3.61 stomach:- intestine:2.28 colon:3.25     liver/hepato:2.37    lung:3.03 bladder:3.96 kidney:3.69 pituitary:2.11 thyroid/parathyroid:2.41 adrenal gland:- pancreas:2.60 breast:4.97 salivary:2.85
RNA-seq uterus:- placenta:- prostate:3.79 ovary:4.69 testis:3.86 heart:2.09 muscle:1.11 esophagus:- stomach:- intestine:- colon:2.71     liver/hepato:1.39        lung:2.09    bladder:- kidney:4.29 pituitary:- thyroid/parathyroid:2.71 adrenal gland:3.42 pancreas:- breast:3.24 salivary:-

Gene Information

IDs

Refseq ID NM_003068
Gene ID 6591
Unigene ID -
Probe set ID 213139_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000019549
GTEx ID ENSG00000019549

Orthologous Gene

Mouse[1]  NM_011415
Rat[1]  NM_011415

Chromosomal Region

8q11.21  [49,830,249  -  49,834,299]

Gene Family (Interpro ID)

IPR015880  Zinc finger, C2H2-like
IPR007087  Zinc finger, C2H2-type

Link to Pubmed  (Pubmed ID)

8125298
9182671
9337409
9721220
10479723
10518215
10866665
11912130
12444107
12477932
14673164
15314165
15337769
15489334
15709186
15734731
15737616
16169465
16344560
16541421
16707493
16717446
16924233
16952353
17194444
17724139
17984306
18056415
18160708
18256147
18485278
18588516
18628477
18663143
18685621
18716062
18799618
18853422
19046938
19381684
19389926
19448627
19460752
19502595
19681038
19751508
19756381
19784072
19821482
20019845
20101232
20128911
20138990
20150431
20418652
20503457
20509143
20564361
20565806
20594328
20622260
20634891
20651304
20730573
20738754
20809941
21044962
21053100
21081648
21120639
21182836
21199805
21207222
21274735
21470622
21532623
21593765
21599940
21632819
21645238
21645451
21647877
21656704
21785273
21808237
21809991
21832049
22028892
22074556
22178381
22208948
22232246
22232555
22288519
22385965
22471696
22490800
22493711
22496452
22503751
22508482
22727060
22745193
22801439
22820858
22886823
22899291
22911700
22937066
22974478
23011797
23029385
23031797
23052737
23059759
23086238
23142026
23190132
23226515
23244088
23248240
23250725
23352643
23354685
23410973
23430442
23434592
23438693
23447531
23521708
23566666
23567973
23634282
23677639
23743248
23815612
23856032
23856093
23900394
23911747
23996472
24001454
24027338
24036252
24100634
24233839
24379252
24657653
24662746

Gene Ontology  (GO ID)

Biological Process

GO:0060536  cartilage morphogenesis
GO:0003273  cell migration involved in endocardial cushion formation
GO:0071364  cellular response to epidermal growth factor stimulus
GO:0071479  cellular response to ionizing radiation
GO:0009790  embryonic development
GO:0001837  epithelial to mesenchymal transition
GO:0003198  epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0060429  epithelium development
GO:0006933  negative regulation of cell adhesion involved in substrate-bound cell migration
GO:0033629  negative regulation of cell adhesion mediated by integrin
GO:0032331  negative regulation of chondrocyte differentiation
GO:0043518  negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0010839  negative regulation of keratinocyte proliferation
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0010957  negative regulation of vitamin D biosynthetic process
GO:0070563  negative regulation of vitamin D receptor signaling pathway
GO:0090090  negative regulation of Wnt receptor signaling pathway through beta-catenin
GO:0014032  neural crest cell development
GO:0007219  Notch signaling pathway
GO:0001649  osteoblast differentiation
GO:0060021  palate development
GO:0043473  pigmentation
GO:0030335  positive regulation of cell migration
GO:0045600  positive regulation of fat cell differentiation
GO:0035066  positive regulation of histone acetylation
GO:0032642  regulation of chemokine production
GO:0045667  regulation of osteoblast differentiation
GO:0007605  sensory perception of sound
GO:0050872  white fat cell differentiation
GO:0060070  Wnt receptor signaling pathway through beta-catenin

Cellular Component

GO:0005737  cytoplasm
GO:0000790  nuclear chromatin
GO:0005634  nucleus

Molecular Function

GO:0003682  chromatin binding
GO:0046872  metal ion binding
GO:0003705  RNA polymerase II transcription factor activity, enhancer binding
GO:0043565  sequence-specific DNA binding