SRY (sex determining region Y)-box 11

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Synonym

Transcription factor SOX-11, SRY (sex determining region Y)-box 11, SOX11

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:36.70 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:41.10 artery/aorta:- vein:- lymphnode:10.10 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:4.80
GeneChip cerebrum:4.18 cerebellum:3.20 brain stem:3.94 corpus callosum/glia:4.40 pineal gland:- peripheral nerve:3.64 spine:5.01 retina:- eye:- artery/aorta:3.02 vein:3.13 lymphnode:2.96 peripheral blood:- spleen:3.37 thymus:3.18 bone marrow:3.08 adipose:2.92 bone:- skin:2.90
CAGE cerebrum:1.18 cerebellum:- brain stem:1.08 corpus callosum/glia:1.62 pineal gland:0.36 peripheral nerve:- spine:1.63 retina:- eye:- artery/aorta:0.18 vein:0 lymphnode:0 peripheral blood:- spleen:0.17 thymus:0 bone marrow:- adipose:0 bone:- skin:-
RNA-seq cerebrum:0.57 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.07 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:4.30 heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:9.80    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:18.60 salivary:-
GeneChip uterus:2.98 placenta:2.80 prostate:2.92 ovary:2.92 testis:2.88 heart:3.12 muscle:3.08 esophagus:3.02 stomach:3.13 intestine:3.15 colon:3.36 liver/hepato:3 lung:2.95 bladder:- kidney:2.86 pituitary:3.23 thyroid/parathyroid:2.93 adrenal gland:2.93 pancreas:3.03 breast:3.04 salivary:2.92
CAGE uterus:0.04 placenta:0.08 prostate:0.08 ovary:0 testis:0.65 heart:0.77 muscle:0.42 esophagus:0.09 stomach:- intestine:0.38 colon:1.14     liver/hepato:0    lung:0.05 bladder:0 kidney:0 pituitary:0.24 thyroid/parathyroid:0 adrenal gland:- pancreas:0 breast:0 salivary:0
RNA-seq uterus:- placenta:- prostate:0.00 ovary:0 testis:0.11 heart:0.15 muscle:0.05 esophagus:- stomach:- intestine:- colon:0.77     liver/hepato:0        lung:0.02    bladder:- kidney:0.02 pituitary:- thyroid/parathyroid:0.00 adrenal gland:0.06 pancreas:- breast:0.22 salivary:-

Gene Information

IDs

Refseq ID NM_003108
Gene ID 6664
Unigene ID Hs.432638
Probe set ID 204913_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000176887
GTEx ID ENSG00000176887

Orthologous Gene

Mouse[2]  NM_009234
Rat [0]  

Chromosomal Region

2p25.2  [5,832,799  -  5,841,516]

Gene Family (Interpro ID)

IPR000910  High mobility group, HMG1/HMG2
IPR009071  High mobility group, superfamily

Link to Pubmed  (Pubmed ID)

8332506
8666406
9632656
10574465
10606637
12100890
12125983
12194848
12477932
12637543
15345747
15944188
16018252
16166090
16276109
17762975
17934069
18029348
19801969
19808959
19880778
19880779
20124476
20383146
20624318
20626275
20919851
21124928
21479697
21738649
21880559
21943380
22738398
22752091
22827557
22915760
22967417
23251661
23266558
23321250
23619925
23648671
23867449
24057671
24145648
24225745

Gene Ontology  (GO ID)

Biological Process

GO:0003211  cardiac ventricle formation
GO:0048557  embryonic digestive tract morphogenesis
GO:0048704  embryonic skeletal system morphogenesis
GO:0021782  glial cell development
GO:0014009  glial cell proliferation
GO:0060022  hard palate development
GO:0001822  kidney development
GO:0002089  lens morphogenesis in camera-type eye
GO:0060174  limb bud formation
GO:0060425  lung morphogenesis
GO:0060548  negative regulation of cell death
GO:0010629  negative regulation of gene expression
GO:0060253  negative regulation of glial cell proliferation
GO:0050672  negative regulation of lymphocyte proliferation
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0014032  neural crest cell development
GO:0001841  neural tube formation
GO:0060563  neuroepithelial cell differentiation
GO:0030182  neuron differentiation
GO:0003357  noradrenergic neuron differentiation
GO:0014003  oligodendrocyte development
GO:0003151  outflow tract morphogenesis
GO:0030513  positive regulation of BMP signaling pathway
GO:0008284  positive regulation of cell proliferation
GO:0010628  positive regulation of gene expression
GO:0046887  positive regulation of hormone secretion
GO:0050769  positive regulation of neurogenesis
GO:0045666  positive regulation of neuron differentiation
GO:0045778  positive regulation of ossification
GO:0045669  positive regulation of osteoblast differentiation
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0017015  regulation of transforming growth factor beta receptor signaling pathway
GO:0001501  skeletal system development
GO:0060023  soft palate development
GO:0021510  spinal cord development
GO:0048485  sympathetic nervous system development
GO:0006412  translation
GO:0060412  ventricular septum morphogenesis

Cellular Component

GO:0005737  cytoplasm
GO:0005634  nucleus

Molecular Function

GO:0008135  translation factor activity, nucleic acid binding