spectrin, beta, non-erythrocytic 2

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Synonym

Spectrin, non-erythroid beta chain 2, Beta-III spectrin, SPTBN2, SCA5, Spectrin beta chain, brain 2, spinocerebellar ataxia 5, KIAA0302, spectrin, beta, non-erythrocytic 2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:6.75 cerebellum:7.82 brain stem:6.41 corpus callosum/glia:5.50 pineal gland:- peripheral nerve:6.44 spine:5.57 retina:- eye:- artery/aorta:5.04 vein:5.45 lymphnode:5.40 peripheral blood:- spleen:4.49 thymus:4.93 bone marrow:5.07 adipose:5.45 bone:- skin:6.77
CAGE cerebrum:4.05 cerebellum:- brain stem:2.30 corpus callosum/glia:1.99 pineal gland:1.18 peripheral nerve:- spine:1.67 retina:- eye:- artery/aorta:0.47 vein:0.18 lymphnode:0.15 peripheral blood:- spleen:0 thymus:0.12 bone marrow:- adipose:0 bone:- skin:-
RNA-seq cerebrum:3.61 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.42 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.67 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:5.08 placenta:4.84 prostate:5.69 ovary:5.27 testis:7.54 heart:5.32 muscle:5.36 esophagus:6.88 stomach:5.13 intestine:5.39 colon:5.02 liver/hepato:6.49 lung:5.16 bladder:- kidney:6.67 pituitary:6.13 thyroid/parathyroid:4.74 adrenal gland:5.72 pancreas:6.07 breast:5.75 salivary:6.43
CAGE uterus:0.29 placenta:0.08 prostate:0.21 ovary:0.07 testis:0.32 heart:0.19 muscle:0 esophagus:0.33 stomach:- intestine:0.14 colon:0.18     liver/hepato:0    lung:0 bladder:0.09 kidney:2.24 pituitary:1.14 thyroid/parathyroid:0 adrenal gland:- pancreas:0 breast:0 salivary:0
RNA-seq uterus:- placenta:- prostate:0.82 ovary:1.07 testis:3.80 heart:0.04 muscle:0.03 esophagus:- stomach:- intestine:- colon:0.35     liver/hepato:2.09        lung:0.38    bladder:- kidney:3.42 pituitary:- thyroid/parathyroid:0.29 adrenal gland:0.50 pancreas:- breast:0.87 salivary:-

Gene Information

IDs

Refseq ID NM_006946
Gene ID 6712
Unigene ID Hs.269151
Probe set ID 205155_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000173898
GTEx ID ENSG00000173898

Orthologous Gene

Mouse[1]  NM_021287
Rat [0]  

Chromosomal Region

11q13.2  [66,452,719  -  66,496,697]

Gene Family (Interpro ID)

IPR016146  Calponin-homology
IPR001715  Calponin-like actin-binding
IPR001849  Pleckstrin homology
IPR018159  Spectrin/alpha-actinin
IPR001605  Spectrin/pleckstrin-like

Link to Pubmed  (Pubmed ID)

7874171
9205841
9675416
9704016
9826670
10852813
11357136
11461920
12119179
12421765
12477932
14702039
15032605
15148151
16429157
17081983
17940722
18003973
19098307
20131405
20301317
20371805
20936779
21139048
21412925
21827906
21853274
21890473
21926972
22457146
22586326
22843192
22939629
23000965
23233669
23236289

Gene Ontology  (GO ID)

Biological Process

GO:0051693  actin filament capping
GO:0030534  adult behavior
GO:0019886  antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0007411  axon guidance
GO:0008219  cell death
GO:0021692  cerebellar Purkinje cell layer morphogenesis
GO:0035264  multicellular organism growth
GO:0007416  synapse assembly
GO:0016192  vesicle-mediated transport

Cellular Component

GO:0043025  cell soma
GO:0005829  cytosol
GO:0008091  spectrin

Molecular Function

GO:0003779  actin binding
GO:0005543  phospholipid binding
GO:0005200  structural constituent of cytoskeleton