squalene epoxidase

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Synonym

SQLE, SE, Squalene monooxygenase, ERG1, squalene epoxidase, Squalene epoxidase

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:113.80 cerebellum:25.20 brain stem:- corpus callosum/glia:58.30 pineal gland:- peripheral nerve:61.30 spine:112.30 retina:118.60 eye:70.50 artery/aorta:179.90 vein:133.30 lymphnode:30.30 peripheral blood:91.10 spleen:- thymus:25.80 bone marrow:19.70 adipose:40.30 bone:38.40 skin:28.80
GeneChip cerebrum:7.91 cerebellum:7.60 brain stem:7.81 corpus callosum/glia:8.55 pineal gland:- peripheral nerve:8.54 spine:8.55 retina:- eye:- artery/aorta:6.91 vein:7.08 lymphnode:7.68 peripheral blood:- spleen:7.33 thymus:7.14 bone marrow:6.88 adipose:7.23 bone:- skin:7.82
CAGE cerebrum:2.90 cerebellum:- brain stem:3.39 corpus callosum/glia:3.82 pineal gland:2.49 peripheral nerve:- spine:3.34 retina:- eye:- artery/aorta:2.10 vein:2.25 lymphnode:2.58 peripheral blood:- spleen:2.25 thymus:2.62 bone marrow:- adipose:2.12 bone:- skin:-
RNA-seq cerebrum:3.50 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.52 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:1.92 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:36.50 placenta:58.30 prostate:45.10 ovary:37.30 testis:324.50 heart:12.80 muscle:- esophagus:- stomach:- intestine:64.80 colon:42.40     liver/hepato:42.20        lung:34.20    bladder:- kidney:10.40 pituitary:- thyroid/parathyroid:- adrenal gland:253.90 pancreas:71.10 breast:55.80 salivary:-
GeneChip uterus:7.47 placenta:7.50 prostate:7.66 ovary:8.08 testis:8.80 heart:7 muscle:6.27 esophagus:8.47 stomach:7.82 intestine:7.37 colon:7.56 liver/hepato:7.88 lung:7.89 bladder:- kidney:7.17 pituitary:7.79 thyroid/parathyroid:7.27 adrenal gland:9.12 pancreas:7.27 breast:7.88 salivary:7.08
CAGE uterus:2.39 placenta:3.17 prostate:2.16 ovary:3.33 testis:3.46 heart:2.07 muscle:1.53 esophagus:3.68 stomach:- intestine:2.65 colon:2.22     liver/hepato:3.21    lung:3.17 bladder:2.30 kidney:2.47 pituitary:2.75 thyroid/parathyroid:2.06 adrenal gland:- pancreas:2.34 breast:2.74 salivary:2.31
RNA-seq uterus:- placenta:- prostate:2.23 ovary:5.17 testis:4.99 heart:1.04 muscle:0.52 esophagus:- stomach:- intestine:- colon:2.00     liver/hepato:4.28        lung:4.38    bladder:- kidney:3.50 pituitary:- thyroid/parathyroid:2.66 adrenal gland:3.07 pancreas:- breast:1.85 salivary:-

Gene Information

IDs

Refseq ID NM_003129
Gene ID 6713
Unigene ID Hs.71465
Probe set ID 213577_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000104549
GTEx ID ENSG00000104549

Orthologous Gene

Mouse[2]  NM_009270
Rat [0]  

Chromosomal Region

8q24.13  [126,010,739  -  126,034,525]

Gene Family (Interpro ID)

IPR003042  Aromatic-ring hydroxylase-like

Link to Pubmed  (Pubmed ID)

8125298
8626488
9286711
10666321
11076863
11230166
12083769
12477932
14702039
15489336
16381901
16806233
17316888
18660489
18728668
19913121
20628086
21139048
21890473
21906983
21988832
23000965
24449766

Gene Ontology  (GO ID)

Biological Process

GO:0006725  cellular aromatic compound metabolic process
GO:0006695  cholesterol biosynthetic process
GO:0010033  response to organic substance
GO:0016126  sterol biosynthetic process

Cellular Component

GO:0005789  endoplasmic reticulum membrane
GO:0016021  integral to membrane
GO:0043231  intracellular membrane-bounded organelle

Molecular Function

GO:0050660  FAD binding
GO:0004506  squalene monooxygenase activity