v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)

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Synonym

ASV, c-src, c-Src, SRC, Proto-oncogene tyrosine-protein kinase Src, SRC1, c-SRC, p60-Src, pp60c-src

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:20.10 cerebellum:12.60 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:30.70 spine:- retina:- eye:11.80 artery/aorta:- vein:133.30 lymphnode:10.10 peripheral blood:18.20 spleen:- thymus:- bone marrow:- adipose:- bone:- skin:33.60
GeneChip cerebrum:6.54 cerebellum:6.29 brain stem:6.34 corpus callosum/glia:6.33 pineal gland:- peripheral nerve:6.54 spine:6.29 retina:- eye:- artery/aorta:6.96 vein:6.89 lymphnode:6.66 peripheral blood:- spleen:6.52 thymus:5.99 bone marrow:5.98 adipose:6.60 bone:- skin:6.26
CAGE cerebrum:2.83 cerebellum:- brain stem:2.00 corpus callosum/glia:2.14 pineal gland:2.74 peripheral nerve:- spine:2.29 retina:- eye:- artery/aorta:3.95 vein:2.82 lymphnode:2.86 peripheral blood:- spleen:3.15 thymus:2.06 bone marrow:- adipose:2.70 bone:- skin:-
RNA-seq cerebrum:0.00 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.00 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.01 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:18.20 placenta:10.90 prostate:78.90 ovary:- testis:17.30 heart:- muscle:- esophagus:- stomach:- intestine:32.40 colon:76.30     liver/hepato:-        lung:107.50    bladder:- kidney:20.80 pituitary:- thyroid/parathyroid:- adrenal gland:50.80 pancreas:35.60 breast:- salivary:-
GeneChip uterus:6.86 placenta:6.69 prostate:6.80 ovary:6.57 testis:7.34 heart:6.43 muscle:6.08 esophagus:7.01 stomach:7.19 intestine:7.05 colon:7.23 liver/hepato:6.27 lung:6.76 bladder:- kidney:7.04 pituitary:7.18 thyroid/parathyroid:6.26 adrenal gland:7.32 pancreas:6.84 breast:6.66 salivary:6.41
CAGE uterus:3.47 placenta:2.60 prostate:3.67 ovary:3.27 testis:3.95 heart:2.67 muscle:1.69 esophagus:3.24 stomach:- intestine:4.22 colon:4.01     liver/hepato:1.57    lung:3.29 bladder:3.54 kidney:2.98 pituitary:2.74 thyroid/parathyroid:2.53 adrenal gland:- pancreas:3.47 breast:2.91 salivary:2.12
RNA-seq uterus:- placenta:- prostate:1.87 ovary:0.03 testis:0.36 heart:0.00 muscle:0.00 esophagus:- stomach:- intestine:- colon:1.23     liver/hepato:0.00        lung:1.19    bladder:- kidney:0.44 pituitary:- thyroid/parathyroid:0.00 adrenal gland:0.00 pancreas:- breast:0.26 salivary:-

Gene Information

IDs

Refseq ID NM_005417
Gene ID 6714
Unigene ID Hs.195659
Probe set ID 213324_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000197122
GTEx ID ENSG00000197122

Orthologous Gene

Mouse[4]  NM_001025395, NM_009271
Rat [0]  

Chromosomal Region

20q11.23  [35,973,088  -  36,034,453]

Gene Family (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

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Gene Ontology  (GO ID)

Biological Process

GO:0007411  axon guidance
GO:0007596  blood coagulation
GO:0045453  bone resorption
GO:0060444  branching involved in mammary gland duct morphogenesis
GO:0007155  cell adhesion
GO:0007049  cell cycle
GO:0071393  cellular response to progesterone stimulus
GO:0007173  epidermal growth factor receptor signaling pathway
GO:0008543  fibroblast growth factor receptor signaling pathway
GO:0030900  forebrain development
GO:0045087  innate immune response
GO:0050900  leukocyte migration
GO:0016044  membrane organization
GO:0043154  negative regulation of caspase activity
GO:0051895  negative regulation of focal adhesion formation
GO:0032463  negative regulation of protein homooligomerization
GO:0048011  nerve growth factor receptor signaling pathway
GO:0048477  oogenesis
GO:0018108  peptidyl-tyrosine phosphorylation
GO:0030168  platelet activation
GO:0070374  positive regulation of ERK1 and ERK2 cascade
GO:0033625  positive regulation of integrin activation
GO:0051897  positive regulation of protein kinase B signaling cascade
GO:0050847  progesterone receptor signaling pathway
GO:0046777  protein amino acid autophosphorylation
GO:0007243  protein kinase cascade
GO:0007265  Ras protein signal transduction
GO:0045124  regulation of bone resorption
GO:0033146  regulation of estrogen receptor signaling pathway
GO:0043393  regulation of protein binding
GO:0043114  regulation of vascular permeability
GO:0070555  response to interleukin-1
GO:0007172  signal complex assembly
GO:0007165  signal transduction
GO:0031295  T cell costimulation
GO:0060065  uterus development
GO:0019048  virus-host interaction

Cellular Component

GO:0005901  caveola
GO:0005737  cytoplasm
GO:0005856  cytoskeleton
GO:0005829  cytosol
GO:0005770  late endosome
GO:0005764  lysosome
GO:0005743  mitochondrial inner membrane
GO:0005634  nucleus
GO:0005886  plasma membrane

Molecular Function

GO:0005524  ATP binding
GO:0046875  ephrin receptor binding
GO:0020037  heme binding
GO:0042802  identical protein binding
GO:0005178  integrin binding
GO:0016301  kinase activity
GO:0004715  non-membrane spanning protein tyrosine kinase activity
GO:0051219  phosphoprotein binding
GO:0005515  protein binding
GO:0004672  protein kinase activity
GO:0004713  protein tyrosine kinase activity
GO:0005102  receptor binding
GO:0042169  SH2 domain binding
GO:0005070  SH3/SH2 adaptor activity