sterol regulatory element binding transcription factor 1

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Synonym

Sterol regulatory element-binding protein 1, SREBF1, SREBP1, SREBP-1

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:328.30

cerebellum:692.70

brain stem:-

corpus callosum/glia:29.20

pineal gland:-

peripheral nerve:122.70

spine:112.30

retina:-

eye:229.20

artery/aorta:-

vein:66.60

lymphnode:10.10

peripheral blood:72.90

spleen:18.90

thymus:657.10

bone marrow:39.40

adipose:-

bone:25.60

skin:81.60

GeneChip

cerebrum:7.05

cerebellum:6.35

brain stem:7.03

corpus callosum/glia:7.86

pineal gland:-

peripheral nerve:7.12

spine:7.20

retina:-

eye:-

artery/aorta:6.70

vein:6.76

lymphnode:7.09

peripheral blood:-

spleen:6.21

thymus:6.82

bone marrow:6.40

adipose:7.37

bone:-

skin:7.19

CAGE

cerebrum:3.95

cerebellum:-

brain stem:4.10

corpus callosum/glia:4.87

pineal gland:3.05

peripheral nerve:-

spine:4.06

retina:-

eye:-

artery/aorta:3.40

vein:3.86

lymphnode:4.04

peripheral blood:-

spleen:3.48

thymus:3.97

bone marrow:-

adipose:3.71

bone:-

skin:-

RNA-seq

cerebrum:2.98

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:0.00

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:0.97

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:54.70

placenta:69.20

prostate:157.70

ovary:-

testis:354.80

heart:38.30

muscle:-

esophagus:-

stomach:-

intestine:-

colon:118.70

liver/hepato:42.20

lung:151.50

bladder:125.60

kidney:52

pituitary:-

thyroid/parathyroid:-

adrenal gland:152.40

pancreas:142.30

breast:37.20

salivary:-

GeneChip

uterus:6.71

placenta:7.07

prostate:7.20

ovary:6.49

testis:7.68

heart:6.05

muscle:6.41

esophagus:7.58

stomach:6.72

intestine:6.55

colon:6.88

liver/hepato:8.52

lung:6.61

bladder:-

kidney:6.82

pituitary:7.32

thyroid/parathyroid:6.70

adrenal gland:8.84

pancreas:6.12

breast:7.97

salivary:7.67

CAGE

uterus:3.61

placenta:4.10

prostate:3.68

ovary:4.42

testis:4.42

heart:3.40

muscle:3.66

esophagus:4.41

stomach:-

intestine:4.68

colon:3.97

liver/hepato:5.13

lung:3.98

bladder:3.83

kidney:3.64

pituitary:3.17

thyroid/parathyroid:2.80

adrenal gland:-

pancreas:2.81

breast:3.92

salivary:4.34

RNA-seq

uterus:-

placenta:-

prostate:1.21

ovary:3.51

testis:2.83

heart:0.33

muscle:1.91

esophagus:-

stomach:-

intestine:-

colon:0.77

liver/hepato:3.50

lung:1.20

bladder:-

kidney:0.33

pituitary:-

thyroid/parathyroid:2.33

adrenal gland:0.39

pancreas:-

breast:3.79

salivary:-

IDs

Refseq ID	NM_001005291
Gene ID	6720
Unigene ID	Hs.592123
Probe set ID	202308_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000072310
GTEx ID	ENSG00000072310

Orthologous Gene

Mouse[1]	NM_011480
Rat[1]	NM_011480

Chromosomal Region

17p11.2 [17,714,653 - 17,740,325]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

Gene Ontology (GO ID)

Biological Process

GO:0007568	aging
GO:0044255	cellular lipid metabolic process
GO:0009267	cellular response to starvation
GO:0008203	cholesterol metabolic process
GO:0008286	insulin receptor signaling pathway
GO:0008610	lipid biosynthetic process
GO:0006629	lipid metabolic process
GO:0030324	lung development
GO:0046676	negative regulation of insulin secretion
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0045542	positive regulation of cholesterol biosynthetic process
GO:0031065	positive regulation of histone deacetylation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0010867	positive regulation of triglyceride biosynthetic process
GO:0019217	regulation of fatty acid metabolic process
GO:0003062	regulation of heart rate by chemical signal
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0051591	response to cAMP
GO:0042493	response to drug
GO:0070542	response to fatty acid
GO:0032094	response to food
GO:0033762	response to glucagon stimulus
GO:0009749	response to glucose stimulus
GO:0032570	response to progesterone stimulus
GO:0032526	response to retinoic acid
GO:0006351	transcription, DNA-dependent

Cellular Component

GO:0044444	cytoplasmic part
GO:0005829	cytosol
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0012507	ER to Golgi transport vesicle membrane
GO:0000139	Golgi membrane
GO:0016021	integral to membrane
GO:0005635	nuclear envelope
GO:0005654	nucleoplasm
GO:0005634	nucleus
GO:0043234	protein complex

Molecular Function

GO:0003682	chromatin binding
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0032403	protein complex binding
GO:0046983	protein dimerization activity
GO:0019901	protein kinase binding
GO:0043565	sequence-specific DNA binding
GO:0032810	sterol response element binding
GO:0003700	transcription factor activity

sterol regulatory element binding transcription factor 1

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function